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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/1.000
1ipeNDPTropinone reductase 21.1.1.2360.499
4hwkNAPSepiapterin reductase1.1.1.1530.498
4j7uNAPSepiapterin reductase1.1.1.1530.482
5idwNAPShort-chain dehydrogenase/reductase SDR/0.481
1ae1NAPTropinone reductase 1/0.477
1snyNAPLD36273p/0.477
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.473
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.473
4j7xNAPSepiapterin reductase1.1.1.1530.473
3sjuNDPKeto reductase/0.468
1oaaNAPSepiapterin reductase1.1.1.1530.466
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.466
2bd0NAPSepiapterin reductase/0.465
5jlaNADPutative short-chain dehydrogenase/reductase/0.461
3p19NDPPutative blue fluorescent protein/0.453
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.453
1xg5NAPDehydrogenase/reductase SDR family member 11/0.452
1w4zNAPPutative ketoacyl reductase1.3.10.451
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.451
3tn7NJPShort-chain alcohol dehydrogenase/0.450
1x7gNAPPutative ketoacyl reductase1.3.10.447
4dc1NDPPutative ketoacyl reductase1.3.10.447
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.444
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.444
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.442