sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1v45 | 3DG | Purine nucleoside phosphorylase | 2.4.2.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1v45 | 3DG | Purine nucleoside phosphorylase | 2.4.2.1 | 1.000 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.625 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.616 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.519 | |
| 1rct | NOS | Purine nucleoside phosphorylase | 2.4.2.1 | 0.517 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.516 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.507 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.505 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.505 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.503 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.503 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.503 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.501 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.501 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.500 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.500 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.499 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.492 | |
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | / | 0.491 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.490 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.489 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.489 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.488 | |
| 3eku | CY9 | Actin-5C | / | 0.488 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.488 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.486 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.486 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.485 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.484 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.484 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.483 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.483 | |
| 1a9p | 9DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.482 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.482 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.482 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.482 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.481 | |
| 1fxu | GU7 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.480 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.480 | |
| 1b8o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.479 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.479 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.479 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.478 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.477 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.477 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.477 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.476 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.476 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.476 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.476 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.476 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.475 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.475 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.475 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.475 | |
| 3o5r | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.475 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.475 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.475 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.474 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.474 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.474 | |
| 1v2h | GUN | Purine nucleoside phosphorylase | 2.4.2.1 | 0.473 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.473 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.472 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.472 | |
| 4nes | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.472 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.472 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.471 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.471 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.471 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.470 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.470 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.470 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.470 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.470 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.470 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.469 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 3qvi | K95 | HAP protein | / | 0.469 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.468 | |
| 1nfy | RTR | Coagulation factor X | 3.4.21.6 | 0.468 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.468 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.468 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.468 | |
| 3cvk | N34 | Genome polyprotein | 2.7.7.48 | 0.468 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.468 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.468 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.468 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.468 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.467 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.467 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.467 | |
| 1p4a | PCP | Pur operon repressor | / | 0.467 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.467 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.467 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.467 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.467 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.467 | |
| 4e32 | DWN | Methyltransferase | / | 0.467 | |
| 4jic | FMN | GTN Reductase | / | 0.467 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.467 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.466 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.466 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.466 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.466 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.466 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.466 | |
| 3gye | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.466 | |
| 3vjl | W94 | Dipeptidyl peptidase 4 | / | 0.466 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.466 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.466 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.465 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.465 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.465 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.465 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.465 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.464 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.464 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.464 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.464 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 3r96 | ACO | MccE protein | / | 0.464 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.464 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 1nj6 | A5A | Proline--tRNA ligase | / | 0.463 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.463 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.463 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.463 | |
| 2wzw | NDP | Nitroreductase NfnB | / | 0.463 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.463 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.462 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.462 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.462 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.462 | |
| 3bnk | FMN | Flavoredoxin | / | 0.462 | |
| 3iei | SAH | Leucine carboxyl methyltransferase 1 | 2.1.1.233 | 0.462 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.462 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.462 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.462 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.462 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.462 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.462 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.462 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.461 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.461 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.461 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.461 | |
| 2dsg | SAH | Diphthine synthase | / | 0.461 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.461 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.461 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.461 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.461 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.461 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.461 | |
| 4e2b | FMN | Dehydrogenase | / | 0.461 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.461 | |
| 4hmx | FMN | Pyridoxamine 5'-phosphate oxidase | / | 0.461 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.461 | |
| 4l4x | NDP | AmphI | / | 0.461 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.460 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.460 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.460 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.460 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.460 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.460 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.460 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.460 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.460 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.460 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.460 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.460 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.460 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.459 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.459 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.459 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.459 | |
| 2b8t | THM | Thymidine kinase | / | 0.459 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.459 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.459 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.459 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.459 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.459 | |
| 4ear | IM5 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.459 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.459 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.458 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.458 | |
| 1wng | SAH | Diphthine synthase | / | 0.458 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.458 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.458 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.458 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.458 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.458 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.457 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.457 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.457 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1r2j | FAD | FkbI | / | 0.457 | |
| 1sa4 | JAN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.457 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.457 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.457 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.457 | |
| 2ibu | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.457 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.457 | |
| 2p6l | SAH | Diphthine synthase | / | 0.457 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.457 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.457 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.457 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.457 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.457 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.457 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.457 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.456 | |
| 1fml | RTL | Retinol dehydratase | / | 0.456 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.456 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.456 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.456 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.456 | |
| 2wvm | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.456 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.456 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.456 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.456 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.455 | |
| 1rz0 | FAD | Phenol 2-hydroxylase component B | / | 0.455 | |
| 1ses | AHX | Serine--tRNA ligase | 6.1.1.11 | 0.455 | |
| 1v5y | 4HC | Major NAD(P)H-flavin oxidoreductase | 1.6.99 | 0.455 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.455 | |
| 2ewv | ADP | Twitching motility protein PilT | / | 0.455 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.455 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.455 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.455 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.455 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.455 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.455 | |
| 4e2d | FMN | Dehydrogenase | / | 0.455 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 1b8n | IMG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.454 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.454 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.454 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.454 | |
| 2pcg | SAH | Diphthine synthase | / | 0.454 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.454 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.454 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.454 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.454 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.454 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.454 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.454 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.454 | |
| 4wso | NAD | Probable nicotinate-nucleotide adenylyltransferase | / | 0.454 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.453 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1snf | UMP | Deoxyuridine 5'-triphosphate nucleotidohydrolase | 3.6.1.23 | 0.453 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.453 | |
| 2hux | SAH | Diphthine synthase | / | 0.453 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.453 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.453 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.453 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.453 | |
| 3v2u | ATP | Protein GAL3 | / | 0.453 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.453 | |
| 4de1 | 0J6 | Beta-lactamase | / | 0.453 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.453 | |
| 4drm | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.453 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.453 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.453 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.453 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.452 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.452 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.452 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.452 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.452 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.452 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.452 | |
| 3w3n | RX8 | Toll-like receptor 8 | / | 0.452 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.452 | |
| 4drk | I63 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.452 | |
| 4gtp | 7TP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.451 | |
| 1jcq | 739 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.451 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.451 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.451 | |
| 1p5r | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.451 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.451 | |
| 2bpo | NAP | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 2e7r | SAH | Diphthine synthase | / | 0.451 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.451 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.451 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.451 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.451 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.451 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.451 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.451 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4rnw | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.451 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.450 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.450 | |
| 1qcw | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.450 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.450 | |
| 2ejz | SAH | Diphthine synthase | / | 0.450 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.450 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.450 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.450 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.450 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.450 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.450 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.450 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.450 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.450 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4d03 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.450 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.450 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.450 | |
| 1aku | FMN | Flavodoxin | / | 0.449 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.449 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.449 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.449 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.449 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.449 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.449 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.449 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.449 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.449 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.449 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.449 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.449 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4de3 | DN8 | Beta-lactamase | / | 0.449 | |
| 4pne | SAH | Methyltransferase-like protein | / | 0.449 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.449 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.449 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.448 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.448 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1pf7 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.448 | |
| 1v48 | HA1 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.448 | |
| 2e07 | SAH | Diphthine synthase | / | 0.448 | |
| 2e8h | SAH | Diphthine synthase | / | 0.448 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.448 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.448 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3hgr | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.448 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.448 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.448 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.448 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.448 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1mbb | EEB | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.447 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.447 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.447 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.447 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.447 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.447 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.447 | |
| 1eje | FMN | Protein MTH_152 | / | 0.446 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.446 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.446 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.446 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.446 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.446 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.446 | |
| 2xlt | NA0 | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.446 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.446 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.446 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.446 | |
| 3qbj | NXZ | Dipeptidyl peptidase 4 | / | 0.446 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.446 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.446 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.446 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.446 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.446 | |
| 1bp6 | UMP | Thymidylate synthase | / | 0.445 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.445 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1s7l | COA | Acetyl transferase | / | 0.445 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.445 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.445 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.445 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2fvc | 888 | Polyprotein | / | 0.445 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.445 | |
| 2nmt | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.445 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.445 | |
| 3pw8 | ACO | 1,2-phenylacetyl-CoA epoxidase, subunit A | 1.14.13.149 | 0.445 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.445 | |
| 4awt | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.445 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.445 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.445 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4kgn | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.445 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4u0m | ATP | Cyclic GMP-AMP synthase | / | 0.445 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.445 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.445 | |
| 4zwm | PLP | Ornithine aminotransferase, mitochondrial, putative | / | 0.445 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.444 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.444 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.444 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.444 | |
| 1yun | ATP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.444 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.444 | |
| 2dsh | SAH | Diphthine synthase | / | 0.444 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.444 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.444 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.444 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.444 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.444 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3px3 | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.444 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.444 | |
| 4e31 | JHZ | Methyltransferase | / | 0.444 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.444 | |
| 4fda | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.444 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.444 | |
| 4jiq | 1L5 | GTN Reductase | / | 0.444 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4uoc | NCN | CinA-like protein | / | 0.444 | |
| 5cyo | GDP | Septin-9 | / | 0.444 | |
| 1bdu | DUR | Thymidylate synthase | / | 0.443 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.443 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 1hi0 | GTP | RNA-directed RNA polymerase | 2.7.7.48 | 0.443 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.443 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1vja | 7IN | Urokinase-type plasminogen activator | 3.4.21.73 | 0.443 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.443 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.443 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.443 | |
| 2pcm | SAH | Diphthine synthase | / | 0.443 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.443 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 3zhy | FM6 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.443 | |
| 4ddy | DN6 | Beta-lactamase | / | 0.443 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.443 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.443 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.443 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.443 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.442 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.442 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1lqd | CMI | Coagulation factor X | 3.4.21.6 | 0.442 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.442 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.442 | |
| 2dxv | SAH | Diphthine synthase | / | 0.442 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.442 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.442 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.442 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.442 | |
| 3eks | CY9 | Actin-5C | / | 0.442 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.442 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.442 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.442 | |
| 3iqg | ASN_TRP_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.442 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4hr2 | ADP | Nucleoside diphosphate kinase | / | 0.442 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.442 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.442 | |
| 4yqf | GDP | Septin-9 | / | 0.442 | |
| 5eso | TDP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.442 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1ja0 | NAP | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1zdw | FLV | Prenyltransferase | / | 0.441 | |
| 2e15 | SAH | Diphthine synthase | / | 0.441 | |
| 2e8q | SAH | Diphthine synthase | / | 0.441 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2ha8 | SAH | Probable methyltransferase TARBP1 | / | 0.441 | |
| 2p5f | SAH | Diphthine synthase | / | 0.441 | |
| 2pck | SAH | Diphthine synthase | / | 0.441 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.441 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.441 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.441 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3ccc | 7AC | Dipeptidyl peptidase 4 | / | 0.441 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.441 | |
| 3ndj | JHZ | Methyltransferase | / | 0.441 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.441 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3w2f | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.441 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.441 | |
| 4js1 | CTN | Beta-galactoside alpha-2,6-sialyltransferase 1 | 2.4.99.1 | 0.441 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.441 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.441 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.441 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.440 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dor | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.440 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.440 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.440 | |
| 1z3c | SA8 | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.440 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.440 | |
| 2ejk | SAH | Diphthine synthase | / | 0.440 | |
| 2emu | SAH | Diphthine synthase | / | 0.440 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.440 | |
| 2huv | SAH | Diphthine synthase | / | 0.440 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.440 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.440 | |
| 3g0d | XIH | Dipeptidyl peptidase 4 | / | 0.440 | |
| 3g11 | P9C | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.440 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.440 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.440 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.440 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.440 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.440 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.440 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.440 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.440 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 6gsu | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.440 |