sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1uma | IN2 | Prothrombin | 3.4.21.5 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 1.000 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.627 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.625 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.621 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.608 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.605 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.597 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.596 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.596 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.587 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.582 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.581 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.579 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.577 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.572 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.571 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.570 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.567 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.565 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.563 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.562 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.562 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.561 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.561 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.560 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.558 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.558 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.556 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.554 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.550 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.549 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.547 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.547 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.545 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.543 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.541 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.539 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.534 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.534 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.532 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.531 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.528 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.528 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.526 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.519 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.516 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.516 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.513 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.511 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.510 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.509 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.508 | |
| 1c1w | BAH | Prothrombin | 3.4.21.5 | 0.505 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.505 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.505 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.504 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.502 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.497 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.496 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.494 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.494 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.491 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.491 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.488 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.488 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.485 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.484 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.483 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.483 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.480 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.478 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.475 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.472 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.469 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.468 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.465 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.464 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.461 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.457 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.457 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.457 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.457 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.455 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.454 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.454 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.452 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.452 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.450 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.447 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.445 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.444 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.443 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.442 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.441 |