Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 |
PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
---|---|---|---|---|---|
1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.594 | |
1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.579 | |
4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.577 | |
3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.523 | |
1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.482 | |
4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.442 |