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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1u54ACPActivated CDC42 kinase 1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1u54ACPActivated CDC42 kinase 1/1.000
1u4dDBQActivated CDC42 kinase 1/0.541
4riyADPEpidermal growth factor receptor2.7.10.10.459
3zewSTUEphrin type-B receptor 42.7.10.10.450
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.448
2qoqANPEphrin type-A receptor 32.7.10.10.448
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.447
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.446
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.445
4zseANPEpidermal growth factor receptor2.7.10.10.445
5e8wSTUTGF-beta receptor type-12.7.11.300.440