sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1tz8 | DES | Transthyretin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1tz8 | DES | Transthyretin | / | 1.000 | |
| 1ict | T44 | Transthyretin | / | 0.612 | |
| 1sn5 | T3 | Transthyretin | / | 0.589 | |
| 1ie4 | T44 | Transthyretin | / | 0.584 | |
| 1sn0 | T44 | Transthyretin | / | 0.496 | |
| 1kgj | FL8 | Transthyretin | / | 0.476 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.472 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.460 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.460 | |
| 3k3b | ADP | Kinesin-like protein KIF11 | / | 0.460 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.458 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.458 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.457 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.457 | |
| 4wq4 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.456 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.454 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.454 | |
| 4wbb | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.451 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 2nom | DUT | Poly(A) polymerase, putative | / | 0.444 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 1ppj | ANY | Cytochrome b | / | 0.442 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3zux | TCH | Transporter | / | 0.440 | |
| 4ohv | ANP | Protein clpf-1 | / | 0.440 | |
| 4xjx | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.440 |