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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tsvUMPThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1tsvUMPThymidylate synthase/1.000
2tdmUMPThymidylate synthase/0.685
2g8aUMPThymidylate synthase/0.668
2g86UMPThymidylate synthase/0.656
1jmhUMPThymidylate synthase/0.617
1njeDCMThymidylate synthase/0.611
1bpjUMPThymidylate synthase/0.607
2g89UMPThymidylate synthase/0.607
1jmgUMPThymidylate synthase/0.590
1tsyUMPThymidylate synthase/0.567
1jmfUMPThymidylate synthase/0.566
1tsxUMPThymidylate synthase/0.561
1vzbUMPThymidylate synthase/0.556
1thyUMPThymidylate synthase/0.555
1njdUMPThymidylate synthase/0.548
1bp6UMPThymidylate synthase/0.535
1jmiUMPThymidylate synthase/0.531
1bidUMPThymidylate synthase/0.526
1njbUMPThymidylate synthase/0.515
1njaDCMThymidylate synthase/0.512
2tddTHFThymidylate synthase/0.510
3bgxTMPThymidylate synthase/0.505
2vetUMPThymidylate synthase/0.500
1vzaUMPThymidylate synthase/0.494
4fogC2FThymidylate synthase ThyA/0.494
2g8dUMPThymidylate synthase/0.490
1lcbDHFThymidylate synthase/0.489
1bduDURThymidylate synthase/0.482
1njcDCMThymidylate synthase/0.474
1vzdCB3Thymidylate synthase/0.473
3bgxMEFThymidylate synthase/0.467
1tslA15Thymidylate synthase/0.461
3bhrTHGThymidylate synthase/0.461
1aobDDUThymidylate synthase/0.460
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
4einNOHThymidylate synthase2.1.1.450.445