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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tkzH16Gag-Pol polyprotein2.7.7.49

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1tkzH16Gag-Pol polyprotein2.7.7.491.000
1tl3H20Gag-Pol polyprotein2.7.7.490.785
1tktH12Gag-Pol polyprotein2.7.7.490.729
1tl1H18Gag-Pol polyprotein2.7.7.490.682
1revTB9Gag-Pol polyprotein2.7.7.490.652
1rt4UC1Gag-Pol polyprotein2.7.7.490.628
1s1wUC1Gag-Pol polyprotein2.7.7.490.620
1c1bGCAGag-Pol polyprotein2.7.7.490.618
2opqHBQGag-Pol polyprotein2.7.7.490.605
3is9AC7Gag-Pol polyprotein2.7.7.490.572
1vruAAPGag-Pol polyprotein2.7.7.490.571
2zd1T27Gag-Pol polyprotein2.7.7.490.567
1ikwEFZGag-Pol polyprotein2.7.7.490.566
1ikxPNUGag-Pol polyprotein2.7.7.490.561
1rt2TNKGag-Pol polyprotein2.7.7.490.561
4id5T27Gag-Pol polyprotein2.7.7.490.561
3i0rRT3Gag-Pol polyprotein2.7.7.490.560
4ko0JLJGag-Pol polyprotein2.7.7.490.558
4g1qT27Gag-Pol polyprotein2.7.7.490.556
4i2pG73Gag-Pol polyprotein2.7.7.490.553
3ffi3OBGag-Pol polyprotein2.7.7.490.552
1ikvEFZGag-Pol polyprotein2.7.7.490.549
2rf2MRXGag-Pol polyprotein2.7.7.490.549
4i7fNVEGag-Pol polyprotein2.7.7.490.548
1hnvTBOGag-Pol polyprotein2.7.7.490.545
1hpzAAPGag-Pol polyprotein2.7.7.490.545
1s6qTPBGag-Pol polyprotein2.7.7.490.545
4ifvT27Gag-Pol polyprotein2.7.7.490.545
2hndNVPGag-Pol polyprotein2.7.7.490.542
3qlhT27Gag-Pol polyprotein2.7.7.490.542
3megT27Gag-Pol polyprotein2.7.7.490.541
4ig3T27Gag-Pol polyprotein2.7.7.490.541
2hnzPC0Gag-Pol polyprotein2.7.7.490.540
2vg7NNIGag-Pol polyprotein2.7.7.490.540
1tkxGWBGag-Pol polyprotein2.7.7.490.536
1rt7UC4Gag-Pol polyprotein2.7.7.490.534
3irxUDRGag-Pol polyprotein2.7.7.490.531
2vg5NNCGag-Pol polyprotein2.7.7.490.530
4kko1REGag-Pol polyprotein2.7.7.490.530
1fk9EFZGag-Pol polyprotein2.7.7.490.529
1rt5UC2Gag-Pol polyprotein2.7.7.490.528
2ban357Gag-Pol polyprotein2.7.7.490.525
3meeT27Gag-Pol polyprotein2.7.7.490.524
1eetBFUGag-Pol polyprotein2.7.7.490.522
1s9eADBGag-Pol polyprotein2.7.7.490.519
2ze2T27Gag-Pol polyprotein2.7.7.490.518
1ikyMSDGag-Pol polyprotein2.7.7.490.515
1jlgUC1Gag-Pol polyprotein2.7.7.490.511
1hquHBYGag-Pol polyprotein2.7.7.490.508
2oppHBQGag-Pol polyprotein2.7.7.490.504
1tvrTB9Gag-Pol polyprotein2.7.7.490.502
1hniAAAGag-Pol polyprotein2.7.7.490.500
3lalKRVGag-Pol polyprotein2.7.7.490.494
3i0sRT7Gag-Pol polyprotein2.7.7.490.492
3nbpJGZGag-Pol polyprotein2.7.7.490.488
3m8qDJZGag-Pol polyprotein2.7.7.490.484
1c1c612Gag-Pol polyprotein2.7.7.490.482
3dleGFAGag-Pol polyprotein2.7.7.490.479
4rw6494Gag-Pol polyprotein2.7.7.490.479
3lamKRPGag-Pol polyprotein2.7.7.490.478
5cyqT27Gag-Pol polyprotein2.7.7.490.476
1s1tUC1Gag-Pol polyprotein2.7.7.490.475
4kfbT27Gag-Pol polyprotein2.7.7.490.474
3dmjGWEPol protein/0.473
3di6PDZGag-Pol polyprotein2.7.7.490.471
1jlcFTCGag-Pol polyprotein2.7.7.490.464
1l2jETCEstrogen receptor beta/0.461
1v7aFRCAdenosine deaminase3.5.4.40.460
1diuBDMDihydrofolate reductase1.5.1.30.459
3dolGWIPol protein/0.459
3lanKBTGag-Pol polyprotein2.7.7.490.459
1jlaTNKGag-Pol polyprotein2.7.7.490.458
1klmSPPGag-Pol polyprotein2.7.7.490.458
1fkoEFZGag-Pol polyprotein2.7.7.490.454
2b5j3ACGag-Pol polyprotein2.7.7.490.452
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
1jlqSBNGag-Pol polyprotein2.7.7.490.451
1w06W05Isopenicillin N synthase1.21.3.10.451
3med65BGag-Pol polyprotein2.7.7.490.450
1rt1MKCGag-Pol polyprotein2.7.7.490.449
2ydoADNAdenosine receptor A2a/0.449
3t1a5MAGag-Pol polyprotein2.7.7.490.449
3m8p65BGag-Pol polyprotein2.7.7.490.448
1osvCHCBile acid receptor/0.447
3zoiM2WIsopenicillin N synthase1.21.3.10.447
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.446
3at4CCKCasein kinase II subunit alpha2.7.11.10.445
3m0eATPTranscriptional regulator (NtrC family)/0.445
3ctj320Hepatocyte growth factor receptor2.7.10.10.444
1aoeGW3Dihydrofolate reductase1.5.1.30.443
1ia2TQ4Dihydrofolate reductase1.5.1.30.442
2z7gEH9Adenosine deaminase3.5.4.40.442
3c6uM22Gag-Pol polyprotein2.7.7.490.442
3bgrT27Gag-Pol polyprotein2.7.7.490.441
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
4mfb29TGag-Pol polyprotein2.7.7.490.441
3dokGWJPol protein/0.440