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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tkbN1TTransketolase 12.2.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1tkbN1TTransketolase 12.2.1.11.000
1tkcM6TTransketolase 12.2.1.10.708
1ay0TPPTransketolase 12.2.1.10.661
1ngsTPPTransketolase 12.2.1.10.627
2r5nTPPTransketolase 1/0.567
1tkaN3TTransketolase 12.2.1.10.551
3rimTPPTransketolase2.2.1.10.506
3uptTPPTransketolase/0.492
1trkTPPTransketolase 12.2.1.10.479
2r8pT6FTransketolase 1/0.465