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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1thyUMPThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1thyUMPThymidylate synthase/1.000
1njcDCMThymidylate synthase/0.614
1jmgUMPThymidylate synthase/0.586
1njaDCMThymidylate synthase/0.585
1tsyUMPThymidylate synthase/0.582
1lcbTMPThymidylate synthase/0.569
1lcbDHFThymidylate synthase/0.566
1jmfUMPThymidylate synthase/0.556
1vzaUMPThymidylate synthase/0.543
1bp6UMPThymidylate synthase/0.535
1njeDCMThymidylate synthase/0.533
1njdUMPThymidylate synthase/0.529
1njbUMPThymidylate synthase/0.526
1tsxUMPThymidylate synthase/0.525
2g89UMPThymidylate synthase/0.521
2g86UMPThymidylate synthase/0.520
1tslA15Thymidylate synthase/0.502
1vzbUMPThymidylate synthase/0.496
1bp0UMPThymidylate synthase/0.495
1jmhUMPThymidylate synthase/0.495
1jmiUMPThymidylate synthase/0.486
1vzdCB3Thymidylate synthase/0.479
1tsvUMPThymidylate synthase/0.469
1bpjUMPThymidylate synthase/0.459
2g8aUMPThymidylate synthase/0.446
2tdmUMPThymidylate synthase/0.446