sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1srg | MHB | Streptavidin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1srg | MHB | Streptavidin | / | 1.000 | |
| 4bx7 | B4F | Streptavidin | / | 0.666 | |
| 2izl | IMI | Streptavidin | / | 0.656 | |
| 2rte | BTN | Streptavidin | / | 0.654 | |
| 1srj | NAB | Streptavidin | / | 0.652 | |
| 1sri | DMB | Streptavidin | / | 0.646 | |
| 2rtd | BTN | Streptavidin | / | 0.646 | |
| 3ry2 | BTN | Streptavidin | / | 0.643 | |
| 1sre | HAB | Streptavidin | / | 0.638 | |
| 2izf | BTN | Streptavidin | / | 0.633 | |
| 1srf | MTB | Streptavidin | / | 0.628 | |
| 1i9h | BNI | Streptavidin | / | 0.623 | |
| 2rtg | BTN | Streptavidin | / | 0.622 | |
| 3wzn | BTN | Streptavidin | / | 0.620 | |
| 2rto | IMI | Streptavidin | / | 0.618 | |
| 1mk5 | BTN | Streptavidin | / | 0.617 | |
| 1srh | MOB | Streptavidin | / | 0.612 | |
| 4gda | BTN | Streptavidin | / | 0.612 | |
| 1lcw | SHM | Streptavidin | / | 0.611 | |
| 1swt | BTN | Streptavidin | / | 0.611 | |
| 2rtn | IMI | Streptavidin | / | 0.611 | |
| 1stp | BTN | Streptavidin | / | 0.606 | |
| 4dne | DTB | Streptavidin | / | 0.606 | |
| 1luq | BTN | Streptavidin | / | 0.600 | |
| 2izg | BTN | Streptavidin | / | 0.599 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.595 | |
| 2rtq | IMI | Streptavidin | / | 0.594 | |
| 2rtk | GLL | Streptavidin | / | 0.583 | |
| 1df8 | BTN | Streptavidin | / | 0.582 | |
| 2avi | BTN | Avidin | / | 0.581 | |
| 2rtr | IMI | Streptavidin | / | 0.578 | |
| 1lcz | BH7 | Streptavidin | / | 0.575 | |
| 2izk | GLL | Streptavidin | / | 0.575 | |
| 2izh | BTN | Streptavidin | / | 0.571 | |
| 2rtf | BTN | Streptavidin | / | 0.568 | |
| 1avd | BTN | Avidin | / | 0.563 | |
| 2y3f | BTN | Streptavidin | / | 0.563 | |
| 3rdq | DTB | Streptavidin | / | 0.563 | |
| 2rti | GLL | Streptavidin | / | 0.562 | |
| 4z28 | BTN | Hoefavidin | / | 0.561 | |
| 2rtp | IMI | Streptavidin | / | 0.560 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.560 | |
| 1rxh | BNI | Streptavidin | / | 0.558 | |
| 3wyq | BTN | Streptavidin | / | 0.557 | |
| 2rtm | IMI | Streptavidin | / | 0.552 | |
| 2jgs | BTN | Avidin | / | 0.547 | |
| 1swn | BTN | Streptavidin | / | 0.546 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.544 | |
| 1nc9 | IMI | Streptavidin | / | 0.543 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.541 | |
| 2uz2 | BTN | Avd protein | / | 0.541 | |
| 2izj | BTN | Streptavidin | / | 0.540 | |
| 2uyw | BTN | Avd protein | / | 0.535 | |
| 2izi | BTN | Streptavidin | / | 0.532 | |
| 1swe | BTN | Streptavidin | / | 0.530 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.530 | |
| 2zsc | BTN | Tamavidin2 | / | 0.526 | |
| 4gd9 | BTN | Streptavidin | / | 0.524 | |
| 1ndj | BTN | Streptavidin | / | 0.521 | |
| 2c4i | BTN | Avidin | / | 0.518 | |
| 1mep | BTN | Streptavidin | / | 0.514 | |
| 1n9m | BTN | Streptavidin | / | 0.514 | |
| 1swp | BTN | Streptavidin | / | 0.509 | |
| 4bj8 | BTN | Avidin | / | 0.509 | |
| 3t2w | BTN | Avidin/streptavidin | / | 0.501 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.498 | |
| 3ew2 | BTN | Hypothetical conserved protein | / | 0.496 | |
| 3wyp | BSO | Streptavidin | / | 0.494 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.492 | |
| 2a5c | 8DA | Avidin | / | 0.491 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.489 | |
| 4rel | KMP | Glycosyltransferase | / | 0.488 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.487 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.483 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.482 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
| 1swd | BTN | Streptavidin | / | 0.478 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.478 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.478 | |
| 3vhh | VHH | Avidin | / | 0.477 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.475 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.475 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.474 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.474 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.473 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 4dli | IRG | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.471 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.471 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.471 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.471 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.471 | |
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.471 | |
| 1xp8 | AGS | Protein RecA | / | 0.470 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.470 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.469 | |
| 1kzi | THG | Thymidylate synthase | / | 0.468 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.468 | |
| 3up0 | D7S | aceDAF-12 | / | 0.468 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.467 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.467 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.467 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.467 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.467 | |
| 3arv | SAU | Chitinase A | / | 0.466 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.466 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.466 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.464 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.464 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.464 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.464 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.464 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.463 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.463 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.463 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.463 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.462 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.462 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.462 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.462 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.462 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.461 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.460 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2rtl | IMI | Streptavidin | / | 0.460 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.460 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.460 | |
| 3vhi | VHI | Avidin | / | 0.460 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.460 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.460 | |
| 1e2n | RCA | Thymidine kinase | / | 0.459 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.459 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.459 | |
| 4mry | CEI | Obelin | / | 0.459 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.459 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.459 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.458 | |
| 2fbw | CBE | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.458 | |
| 2fbw | CBE | Succinate dehydrogenase cytochrome b, large subunit | / | 0.458 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.458 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.458 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.458 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.458 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.457 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.457 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.457 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.457 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.457 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.456 | |
| 2zi6 | 3D1 | Deoxycytidine kinase | 2.7.1.74 | 0.456 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.456 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.456 | |
| 1eio | GCH | Gastrotropin | / | 0.455 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.455 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.455 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.455 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.455 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.454 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.454 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.454 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.454 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.454 | |
| 3gtc | GTC | Beta-lactamase | 3.5.2.6 | 0.454 | |
| 3vgw | NVZ | Avidin | / | 0.454 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.454 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.454 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1ycg | FMN | Nitric oxide reductase | 1 | 0.453 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.453 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.453 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.453 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.453 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.453 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.453 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.452 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.452 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.452 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.452 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.452 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.452 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.451 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.451 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.451 | |
| 2a2s | GSN | Glutathione S-transferase P | 2.5.1.18 | 0.451 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.451 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.451 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.451 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.451 | |
| 5dp2 | NAP | CurF | / | 0.451 | |
| 5dxj | SFG | Histone-arginine methyltransferase CARM1 | / | 0.451 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.450 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.450 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.450 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.450 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.450 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.450 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.450 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.450 | |
| 4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.450 | |
| 5cfn | 2BA | Stimulator of interferon genes protein | / | 0.450 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.450 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.449 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.449 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.449 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.449 | |
| 2zrx | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 4gkm | 683 | Anthranilate phosphoribosyltransferase | / | 0.449 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.449 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.448 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.448 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.448 | |
| 2npf | MOU | Elongation factor 2 | / | 0.448 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.448 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.448 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.447 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.447 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.447 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.447 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.447 | |
| 2fto | TMP | Thymidylate synthase | / | 0.447 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.447 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.447 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.447 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.447 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
| 3tp0 | FO5 | HTH-type transcriptional regulator EthR | / | 0.447 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.447 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 1cde | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.446 | |
| 1fml | RTL | Retinol dehydratase | / | 0.446 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.446 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.446 | |
| 2imf | TOM | 2-hydroxychromene-2-carboxylate isomerase | 5.99.1.4 | 0.446 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.446 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3rup | ADP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.446 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.446 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.446 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.445 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.445 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.445 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.445 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.445 | |
| 1r2j | FAD | FkbI | / | 0.445 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.445 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.445 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.445 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.445 | |
| 2zf4 | PPY | Uncharacterized protein | / | 0.445 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.445 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.445 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.445 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.444 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.444 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.444 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.444 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.444 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.444 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.443 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.443 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.443 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.443 | |
| 2toh | HBI | Tyrosine 3-monooxygenase | 1.14.16.2 | 0.443 | |
| 2vmy | FFO | Serine hydroxymethyltransferase | / | 0.443 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.443 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3pld | F90 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.443 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.443 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.442 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.442 | |
| 1nqm | BTN | Streptavidin | / | 0.442 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.442 | |
| 1uhj | CZB | Aequorin-2 | / | 0.442 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.442 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.442 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.442 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.442 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4hzo | COA | Conserved hypthetical protein | / | 0.442 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.442 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.442 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.441 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 1pw1 | HEL | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.441 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.441 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.441 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.441 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.441 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2r8o | T5X | Transketolase 1 | / | 0.441 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.441 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.441 | |
| 3arq | DM5 | Chitinase A | / | 0.441 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.441 | |
| 3rdo | BTN | Streptavidin | / | 0.441 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.441 | |
| 3znq | SS8 | D-amino-acid oxidase | 1.4.3.3 | 0.441 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.441 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.440 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.440 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.440 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.440 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.440 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.440 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.440 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.440 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.440 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.440 | |
| 3up3 | XCA | aceDAF-12 | / | 0.440 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.440 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 4ggz | BTN | Bll1558 protein | / | 0.440 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.440 |