sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1sg9	SAM	Release factor glutamine methyltransferase	2.1.1.297

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1sg9	SAM	Release factor glutamine methyltransferase	2.1.1.297	1.000
1nv8	SAM	Release factor glutamine methyltransferase	2.1.1.297	0.626
1nv9	SAH	Release factor glutamine methyltransferase	2.1.1.297	0.605
1vq1	SAM	Release factor glutamine methyltransferase	2.1.1.297	0.565
2np7	NEA	Modification methylase TaqI	2.1.1.72	0.463
1ve3	SAM	Uncharacterized protein	/	0.462
5bxy	SAH	Putative RNA methylase family UPF0020	/	0.453
2ih2	NEA	Modification methylase TaqI	2.1.1.72	0.450
1h36	R88	Squalene--hopene cyclase	4.2.1.129	0.444
2ok7	FAD	Ferredoxin--NADP reductase, apicoplast	/	0.443
3ha3	SAH	Hydroxymycolate synthase MmaA4	2.1.1	0.442
4i6g	FAD	Cryptochrome-2	/	0.440