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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.581.000
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.659
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.646
1s63778Protein farnesyltransferase subunit beta2.5.1.580.643
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.636
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.630
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.629
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.626
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.623
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.618
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.616
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.616
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.616
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.603
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.602
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.596
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.578
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.562
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.549
3q7fED2Uncharacterized protein/0.523
3sfy3FYUncharacterized protein/0.520
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.514
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.505
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.488
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.487
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.483
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.483
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.483
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.466
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.465
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.462
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.456
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.445