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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1sa4JANProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1sa4JANProtein farnesyltransferase subunit beta2.5.1.581.000
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.787
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.784
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.747
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.723
1s63778Protein farnesyltransferase subunit beta2.5.1.580.707
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.693
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.646
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.631
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.626
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.620
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.618
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.618
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.615
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.612
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.611
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.605
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.558
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.552
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.530
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.530
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.508
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.506
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.498
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.492
3q7fED2Uncharacterized protein/0.485
3sfy3FYUncharacterized protein/0.483
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.476
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.473
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.580.472
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.466
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.453
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.453
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.448