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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1s22ATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1s22ATPActin, alpha skeletal muscle/1.000
1rgiATPActin, alpha skeletal muscle/0.540
2q36ATPActin, alpha skeletal muscle/0.538
1qz5ATPActin, alpha skeletal muscle/0.522
3a5mATPMajor actin/0.521
4k42ADPActin, alpha skeletal muscle/0.516
4pkgATPActin, alpha skeletal muscle/0.515
1nm1ATPMajor actin/0.503
4pl8ATPActin, alpha skeletal muscle/0.495
1wuaATPActin, alpha skeletal muscle/0.493
1h1vATPActin, alpha skeletal muscle/0.490
4cbxATPActin-2/0.485
1t44ATPActin, alpha skeletal muscle/0.481
3tu5ATPActin, alpha skeletal muscle/0.481
5ce3ATPActin/0.480
1ijjATPActin, alpha skeletal muscle/0.479
3mn9ATPActin-5C/0.479
4jhdANPActin-5C/0.465
4ci6ATPActin/0.462
3u9dATPActin, alpha skeletal muscle/0.458
1mduATPActin, alpha skeletal muscle/0.451
2q97ATPActin, alpha skeletal muscle/0.451
4k41ATPActin, alpha skeletal muscle/0.445