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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1s1cGNPTransforming protein RhoA

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1s1cGNPTransforming protein RhoA/1.000
1kmqGNPTransforming protein RhoA/0.509
1cxzGSPTransforming protein RhoA/0.482
4xoiGTPTransforming protein RhoA/0.470
2gcpGSPRho-related GTP-binding protein RhoC/0.468
5hpyGDPTransforming protein RhoA/0.468
1z2cGNPRho-related GTP-binding protein RhoC/0.461
3kz1GSPTransforming protein RhoA/0.457
1m7bGTPRho-related GTP-binding protein RhoE/0.451