sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1rsz	DIH	Purine nucleoside phosphorylase	2.4.2.1

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1rsz	DIH	Purine nucleoside phosphorylase	2.4.2.1	1.000
2a0w	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.713
2a0y	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.658
2a0x	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.638
1rt9	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.577
1rr6	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.530
1rfg	GMP	Purine nucleoside phosphorylase	2.4.2.1	0.499
3ggs	2FD	Purine nucleoside phosphorylase	2.4.2.1	0.467
2oc4	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.461
2on6	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.458
3k8q	22A	Purine nucleoside phosphorylase	2.4.2.1	0.452
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.444