sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1rpn | NDP | GDP-mannose 4,6-dehydratase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 1.000 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.632 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.606 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.537 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.504 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.499 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.493 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.493 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.491 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.487 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.485 | |
| 4eo3 | FMN | Bacterioferritin comigratory protein/NADH dehydrogenase | / | 0.485 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.484 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.480 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.478 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.477 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.476 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.476 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.475 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.475 | |
| 1iy8 | NAD | Levodione reductase | / | 0.475 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.474 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.472 | |
| 3ing | NDP | Homoserine dehydrogenase related protein | / | 0.472 | |
| 1jdv | ADN | Purine nucleoside phosphorylase | / | 0.471 | |
| 2vf7 | ADP | UvrABC system protein A | / | 0.471 | |
| 2xb9 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.471 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.471 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.471 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.470 | |
| 1p4a | PCP | Pur operon repressor | / | 0.470 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.470 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.469 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.468 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.468 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.468 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.467 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.467 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.467 | |
| 2rab | FAD | Glutathione amide reductase | / | 0.467 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.467 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.466 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.466 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.466 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.465 | |
| 3eku | CY9 | Actin-5C | / | 0.465 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.465 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.465 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.464 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.464 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.464 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.464 | |
| 1p5r | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.463 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2e15 | SAH | Diphthine synthase | / | 0.463 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.463 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.462 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.462 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.462 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.462 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.461 | |
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 | 0.461 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.461 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.461 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.461 | |
| 1zdf | UPG | Glycogenin-1 | 2.4.1.186 | 0.461 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.461 | |
| 1sny | NAP | LD36273p | / | 0.460 | |
| 4c1e | MCO | Beta-lactamase class B VIM-2 | / | 0.460 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.459 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 2e07 | SAH | Diphthine synthase | / | 0.459 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.459 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 2g9v | IFM | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.459 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.459 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.459 | |
| 3c8a | ARG_ARG_GLY_LEU_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.459 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.459 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.458 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.458 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 3beo | UD1 | UDP-N-acetylglucosamine 2-epimerase | / | 0.458 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.458 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.458 | |
| 1jdt | MTA | Purine nucleoside phosphorylase | / | 0.457 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.457 | |
| 2dph | NAD | Formaldehyde dismutase | / | 0.457 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.457 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.457 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.457 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.457 | |
| 4e5h | 0N8 | Polymerase acidic protein | / | 0.457 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.456 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.456 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.456 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.456 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.456 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.456 | |
| 3g0c | RUF | Dipeptidyl peptidase 4 | / | 0.456 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.456 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.456 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.456 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.455 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.455 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.455 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.455 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.455 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.455 | |
| 4nau | AGS | Phosphopantetheine adenylyltransferase | / | 0.455 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.454 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.454 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.454 | |
| 2zrj | AGS | Protein RecA | / | 0.454 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.454 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.454 | |
| 4ck2 | NVU | Integrase | / | 0.454 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.454 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.454 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.454 | |
| 4s26 | SAH | Phosphomethylpyrimidine synthase, chloroplastic | 4.1.99.17 | 0.454 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.453 | |
| 1ijj | LAR | Actin, alpha skeletal muscle | / | 0.453 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.453 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.453 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.453 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.453 | |
| 3eks | CY9 | Actin-5C | / | 0.453 | |
| 3ixk | 929 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.453 | |
| 3zhy | FM6 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.453 | |
| 4a5s | N7F | Dipeptidyl peptidase 4 | / | 0.453 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.453 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.452 | |
| 1lde | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.452 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.452 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.452 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4die | C5P | Cytidylate kinase | / | 0.452 | |
| 4fdu | IHS | Putative multiple inositol polyphosphate histidine phosphatase 1 | / | 0.452 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.452 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.452 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.451 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.451 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.451 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.451 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.451 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.451 | |
| 3e39 | FMN | Nitroreductase | / | 0.451 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.451 | |
| 4dtb | GMP | APH(2'')-Id | / | 0.451 | |
| 4ehz | JAK | Tyrosine-protein kinase JAK1 | / | 0.451 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.450 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.450 | |
| 1w51 | L01 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 1xh7 | R96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.450 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.450 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.450 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.450 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.450 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.450 | |
| 2e4n | SAH | Diphthine synthase | / | 0.449 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 3elc | F01 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.449 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.449 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.449 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.449 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.449 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.449 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.449 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.448 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.448 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.448 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.448 | |
| 4i5c | C5I | Tyrosine-protein kinase JAK1 | / | 0.448 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.448 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.448 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.447 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.447 | |
| 1yki | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.447 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.447 | |
| 2wzm | NA7 | Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346 | / | 0.447 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.447 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.447 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.447 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.447 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.447 | |
| 3pfi | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.447 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.447 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.447 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.447 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.447 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.447 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.446 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.446 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.446 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.446 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.446 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.446 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.446 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.446 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.446 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.446 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.446 | |
| 4ks7 | X4Z | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.446 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.446 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.446 | |
| 4z38 | FMN | MlnA | / | 0.446 | |
| 5kjf | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.445 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.445 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1sdm | ADP | Kinesin heavy chain-like protein | / | 0.445 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.445 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.445 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 2bkj | FMN | NADPH-flavin oxidoreductase | / | 0.445 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.445 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.445 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.445 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.445 | |
| 4opu | FDA | Conserved Archaeal protein | / | 0.445 | |
| 4qxp | 1YE | Stimulator of interferon genes protein | / | 0.445 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.445 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.445 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.444 | |
| 1til | ATP | Anti-sigma F factor | / | 0.444 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.444 | |
| 1z41 | FMN | NADPH dehydrogenase | / | 0.444 | |
| 2p5c | SAH | Diphthine synthase | / | 0.444 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.444 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.444 | |
| 4fda | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.444 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.444 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.444 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.444 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.444 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.444 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.444 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.443 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.443 | |
| 1s4e | ADP | Galactokinase | / | 0.443 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.443 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.443 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.443 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.443 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.443 | |
| 3utd | 0CJ | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.443 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.443 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4eb3 | 0O3 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.443 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.443 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.443 | |
| 4iac | ACP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.442 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.442 | |
| 1lny | IMO | Adenylosuccinate synthetase isozyme 1 | / | 0.442 | |
| 1yqy | 915 | Lethal factor | 3.4.24.83 | 0.442 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.442 | |
| 2j08 | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.442 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.442 | |
| 2p6l | SAH | Diphthine synthase | / | 0.442 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.442 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 3ae4 | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.442 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.442 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.442 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.442 | |
| 3qw4 | U5P | Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | / | 0.442 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3zid | GDP | Tubulin-like protein CetZ | / | 0.442 | |
| 4a0r | DTB | Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial | 6.3.3.3 | 0.442 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.442 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.442 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 1e2n | RCA | Thymidine kinase | / | 0.441 | |
| 1i6k | TYM | Tryptophan--tRNA ligase | 6.1.1.2 | 0.441 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.441 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.441 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.441 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.441 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.441 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.441 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.441 | |
| 3q1f | YPP | Beta-lactamase | / | 0.441 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.441 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.441 | |
| 3ua8 | 08W | Glutamate receptor 2 | / | 0.441 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.441 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.441 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.441 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.441 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.440 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ses | AHX | Serine--tRNA ligase | 6.1.1.11 | 0.440 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.440 | |
| 2bpo | NAP | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.440 | |
| 2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2xda | JPS | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.440 | |
| 3udk | 095 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4opl | FDA | Conserved Archaeal protein | / | 0.440 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.440 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.440 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.440 |