sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1ri3	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1ri3	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56	1.000
1z3c	SA8	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.608
2hv9	SFG	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.600
1ri1	GTG	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.572
1ri4	SAM	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.565
1ri2	GTG	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.478
4ckb	SAH	mRNA-capping enzyme catalytic subunit	2.1.1.56	0.455
5e9w	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.448