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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rf7DHFDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1rf7DHFDihydrofolate reductase1.5.1.31.000
1dyjDDFDihydrofolate reductase1.5.1.30.543
1rx7FOLDihydrofolate reductase1.5.1.30.518
1jolFFODihydrofolate reductase1.5.1.30.516
1re7FOLDihydrofolate reductase1.5.1.30.513
1ddsMTXDihydrofolate reductase1.5.1.30.508
1dhjMTXDihydrofolate reductase1.5.1.30.507
3och2MXDihydrofolate reductase1.5.1.30.499
4ej1FOLDihydrofolate reductase1.5.1.30.498
1rc4DDFDihydrofolate reductase1.5.1.30.481
1rd7FOLDihydrofolate reductase1.5.1.30.478
2d0kFOLDihydrofolate reductase1.5.1.30.476
5hi6MTXDihydrofolate reductase/0.473
1draMTXDihydrofolate reductase1.5.1.30.470
1rx5DDFDihydrofolate reductase1.5.1.30.466
4dfrMTXDihydrofolate reductase1.5.1.30.463
2drcMTXDihydrofolate reductase1.5.1.30.461
1ddrMTXDihydrofolate reductase1.5.1.30.459
1tdrMTXDihydrofolate reductase1.5.1.30.458
1dyiFOLDihydrofolate reductase1.5.1.30.457
3drcMTXDihydrofolate reductase1.5.1.30.457
4i1nFOLDihydrofolate reductase1.5.1.30.454
1dg8NDPDihydrofolate reductase1.5.1.30.445
3fl8RARDihydrofolate reductase/0.445