Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 1.000 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.704 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.613 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.613 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.556 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.549 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.544 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.519 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.512 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.511 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.504 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.496 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.496 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.495 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.493 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.492 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.489 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.487 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.483 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.483 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.481 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.479 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.478 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.478 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.477 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.476 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.476 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.476 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.475 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.474 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.473 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.472 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.472 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.471 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 4ple | CPS | Nuclear receptor subfamily 5 group A member 2 | / | 0.471 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.470 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.470 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.470 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.470 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.470 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.470 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.469 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.469 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.469 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 1in5 | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.468 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.468 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.467 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.467 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.466 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.466 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.466 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 2bxq | IMN | Serum albumin | / | 0.465 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.465 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.465 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.465 | |
| 1yvf | PH7 | Polyprotein | / | 0.464 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.464 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.464 | |
| 2xvv | 9DN | Serum albumin | / | 0.464 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.464 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.464 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.464 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.463 | |
| 3c1o | NAP | Eugenol synthase | / | 0.463 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 1kqo | DND | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.462 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.462 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.462 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.462 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 2ohv | NHL | Glutamate racemase | / | 0.462 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.462 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.462 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.461 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.461 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.461 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.461 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.460 | |
| 1sxj | AGS | Replication factor C subunit 1 | / | 0.460 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.460 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 4ie0 | PD2 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.460 | |
| 2bxm | IMN | Serum albumin | / | 0.459 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 2xvw | 9NR | Serum albumin | / | 0.459 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 5a3b | APR | SIR2 family protein | / | 0.459 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.458 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.458 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.458 | |
| 4guk | P2G | Neuronal calcium sensor 1 | / | 0.458 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.458 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.457 | |
| 1mr9 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.457 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.457 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.456 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.455 | |
| 1osv | CHC | Bile acid receptor | / | 0.455 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.455 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4nvk | 2NY | Peroxidase | / | 0.455 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 3tyd | XHP | Dihydropteroate synthase | / | 0.454 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.454 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.454 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.453 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.453 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.453 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.453 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.452 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.452 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.452 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.452 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 4jic | FMN | GTN Reductase | / | 0.452 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.452 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.451 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.451 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.451 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.451 | |
| 3eej | 53R | Uncharacterized protein | / | 0.451 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.451 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.450 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.450 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.450 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.450 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.450 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.450 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 1gqy | ACP | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.449 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.449 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.449 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.449 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.449 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.449 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.449 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.448 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.448 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 3up0 | D7S | aceDAF-12 | / | 0.448 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.448 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.448 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 2jfz | 003 | Glutamate racemase | / | 0.447 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.447 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.447 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3jt3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.447 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.447 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.447 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 4v12 | POG | MaoC like domain protein | / | 0.447 | |
| 5a3c | NAD | SIR2 family protein | / | 0.447 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.447 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.446 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.446 | |
| 3gwd | NAP | Cyclohexanone monooxygenase | / | 0.446 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.446 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.446 | |
| 3v2u | ATP | Protein GAL3 | / | 0.446 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.446 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.446 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.446 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.446 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.445 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 2cbs | R13 | Cellular retinoic acid-binding protein 2 | / | 0.445 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.445 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.445 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.445 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.445 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.445 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.445 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.445 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.445 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.445 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.445 | |
| 1c7o | PPG | Hemolysin | / | 0.444 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.444 | |
| 1qm5 | PLP | Maltodextrin phosphorylase | 2.4.1.1 | 0.444 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.444 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.444 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.444 | |
| 3u9e | COA | Lmo1369 protein | / | 0.444 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.444 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.444 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.444 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.444 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.443 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.443 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.443 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.443 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.443 | |
| 3b9l | AZZ | Serum albumin | / | 0.443 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.443 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.443 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.443 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.443 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.442 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.442 | |
| 1tys | TMP | Thymidylate synthase | / | 0.442 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.442 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.442 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.442 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.442 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.442 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.442 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.442 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.442 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.442 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.442 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.441 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.441 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.441 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.441 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1o1v | TCH | Gastrotropin | / | 0.440 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2ako | ADP | Glutamate 5-kinase | / | 0.440 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.440 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 3eld | SFG | Methyltransferase | / | 0.440 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.440 | |
| 4hxy | NDP | Plm1 | / | 0.440 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.440 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.440 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.440 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.440 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.440 |