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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qcfPP1Tyrosine-protein kinase HCK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1qcfPP1Tyrosine-protein kinase HCK2.7.10.21.000
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.565
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.562
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.561
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.536
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.535
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.521
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.509
3vs3VSETyrosine-protein kinase HCK2.7.10.20.500
3w33W19Epidermal growth factor receptor2.7.10.10.476
3rkb12ZCyclin-dependent kinase 22.7.11.220.465
3vs1VSATyrosine-protein kinase HCK2.7.10.20.458
4y93746Tyrosine-protein kinase/0.458
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.448
3w2sW2REpidermal growth factor receptor2.7.10.10.443
3w32W32Epidermal growth factor receptor2.7.10.10.440
4y95746Tyrosine-protein kinase/0.440