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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/1.000
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.581.000
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.516
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.516
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.512
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.512
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.508
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.505
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.504
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.498
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.498
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.492
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.580.486
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.481
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.458
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.452