sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1q4x | G24 | Thyroid hormone receptor beta |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1q4x | G24 | Thyroid hormone receptor beta | / | 1.000 | |
| 1r6g | 442 | Thyroid hormone receptor beta | / | 0.595 | |
| 1nq1 | 4HY | Thyroid hormone receptor beta | / | 0.522 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.516 | |
| 1nq2 | 4HY | Thyroid hormone receptor beta | / | 0.514 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.494 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.491 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.490 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.488 | |
| 3d57 | 4HY | Thyroid hormone receptor beta | / | 0.488 | |
| 1nax | IH5 | Thyroid hormone receptor beta | / | 0.487 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.485 | |
| 3q0v | LL4 | HTH-type transcriptional regulator EthR | / | 0.484 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.484 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.480 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.480 | |
| 1n46 | PFA | Thyroid hormone receptor beta | / | 0.479 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.477 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.476 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.475 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.475 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.475 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.475 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.473 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.473 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.473 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.473 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.473 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.472 | |
| 3x06 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.472 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.472 | |
| 2zbz | VDX | Vitamin D3 dihydroxylase | / | 0.471 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.471 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.471 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.471 | |
| 1fml | RTL | Retinol dehydratase | / | 0.470 | |
| 2j4a | OEF | Thyroid hormone receptor beta | / | 0.470 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.470 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.469 | |
| 2pin | 4HY | Thyroid hormone receptor beta | / | 0.469 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.469 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.468 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.468 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.467 | |
| 1g67 | TZP | Thiamine-phosphate synthase | / | 0.466 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.466 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.466 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.465 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.465 | |
| 3up0 | D7S | aceDAF-12 | / | 0.465 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.465 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.464 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.464 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.464 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.463 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.463 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.463 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.463 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.463 | |
| 1r9o | FLP | Cytochrome P450 2C9 | / | 0.462 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.462 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.462 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.462 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.462 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.462 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.461 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.461 | |
| 3up3 | XCA | aceDAF-12 | / | 0.461 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.461 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.461 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.461 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.460 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.460 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.460 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.460 | |
| 2hl1 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.460 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.460 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.460 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.460 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.460 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.460 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.460 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.459 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.459 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.459 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.459 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.458 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.458 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.458 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.458 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.458 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.458 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.458 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.458 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.457 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.457 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.457 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.457 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.457 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.457 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.456 | |
| 3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.456 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.456 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.456 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.456 | |
| 1jut | LYD | Thymidylate synthase | / | 0.455 | |
| 1osv | CHC | Bile acid receptor | / | 0.455 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.455 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.455 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.455 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.455 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.454 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2bx8 | AZQ | Serum albumin | / | 0.454 | |
| 2x7f | 824 | TRAF2 and NCK-interacting protein kinase | 2.7.11.1 | 0.454 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.454 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.454 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.454 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.453 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.453 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.453 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.453 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.453 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.452 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.452 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.452 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.452 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.452 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.452 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.452 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.452 | |
| 4e2b | FMN | Dehydrogenase | / | 0.452 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.452 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.452 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.451 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.451 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.451 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.451 | |
| 1nav | IH5 | Thyroid hormone receptor alpha | / | 0.450 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.450 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.450 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.450 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.450 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.450 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.450 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.450 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.450 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.450 | |
| 4pd6 | URI | Nucleoside permease | / | 0.450 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.450 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.450 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.449 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.449 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.449 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.449 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.449 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.449 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.449 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.448 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.448 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.448 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.448 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.448 | |
| 3p9t | TCL | Repressor | / | 0.448 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.448 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.448 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.448 | |
| 5ahk | TPP | Acetolactate synthase II, large subunit | / | 0.448 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.447 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.447 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2y05 | RAL | Prostaglandin reductase 1 | / | 0.447 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.447 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.447 | |
| 3ldf | SAH | Uncharacterized protein | / | 0.447 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.447 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.447 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.447 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.447 | |
| 4l4x | NDP | AmphI | / | 0.447 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.446 | |
| 1chw | HXC | Chalcone synthase 2 | 2.3.1.74 | 0.446 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.446 | |
| 1uum | AFI | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.446 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2xiz | XIZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3bej | MUF | Bile acid receptor | / | 0.446 | |
| 4anm | WUL | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.446 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.446 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.446 | |
| 4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.446 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.445 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.445 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.445 | |
| 3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.445 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.445 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.445 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ee0 | CAA | 2-pyrone synthase | / | 0.444 | |
| 1s5k | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.444 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.444 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.444 | |
| 3eya | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.444 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.444 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.444 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.444 | |
| 3u4u | LNH | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.444 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.444 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.443 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.443 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.443 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.443 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.443 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.443 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.443 | |
| 3m8p | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 4c4h | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.443 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.443 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.442 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.442 | |
| 1t1s | CBQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.442 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.442 | |
| 2oo5 | TXD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.442 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.442 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.442 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.442 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.442 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.442 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.442 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.441 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 1m2p | HNA | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1yi3 | LY2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.441 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.441 | |
| 3ept | FDA | Putative FAD-monooxygenase | / | 0.441 | |
| 3h1j | SMA | Cytochrome b | / | 0.441 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.441 | |
| 3vbq | 0F5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.441 | |
| 4bi1 | ZO6 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.441 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.441 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1het | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.440 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.440 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.440 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2pyw | ADP | Methylthioribose kinase | 2.7.1.100 | 0.440 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.440 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 3cx5 | SMA | Cytochrome b | / | 0.440 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.440 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.440 | |
| 3vhm | NPK | Avidin | / | 0.440 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4jk4 | DIU | Serum albumin | / | 0.440 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4mzu | COA | WxcM-like protein | / | 0.440 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.440 | |
| 4qms | 1N1 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.440 |