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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1q41IXMGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1q41IXMGlycogen synthase kinase-3 beta2.7.11.261.000
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.609
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.596
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.549
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.548
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.543
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.539
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.529
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.520
4dgmAGICasein kinase II subunit alpha2.7.11.10.519
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.516
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.509
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.504
2pvnP63Casein kinase II subunit alpha2.7.11.10.501
4fv6E57Mitogen-activated protein kinase 12.7.11.240.501
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.499
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.499
3be9P04Casein kinase II subunit alpha2.7.11.10.498
3rak03ZCyclin-dependent kinase 22.7.11.220.498
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.495
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.494
4dgnLU2Casein kinase II subunit alpha2.7.11.10.493
3zh8C58Protein kinase C iota type2.7.11.130.487
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.486
2pvhP19Casein kinase II subunit alpha2.7.11.10.485
5e8ySTUTGF-beta receptor type-22.7.11.300.485
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.483
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.482
4dgo0JWCasein kinase II subunit alpha2.7.11.10.482
4fkv61KCyclin-dependent kinase 22.7.11.220.482
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.480
3i60E86Mitogen-activated protein kinase 12.7.11.240.480
2vv9IM9Cyclin-dependent kinase 22.7.11.220.479
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.478
1y91CT9Cyclin-dependent kinase 22.7.11.220.474
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.474
4jboWPHAurora kinase A2.7.11.10.473
4hge15VTyrosine-protein kinase JAK2/0.472
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.471
3s1h56ZCyclin-dependent kinase 22.7.11.220.471
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.470
4jajXU1Aurora kinase A2.7.11.10.469
3du8553Glycogen synthase kinase-3 beta2.7.11.260.467
5dr9SKEAurora kinase A2.7.11.10.467
4hvi19STyrosine-protein kinase JAK32.7.10.20.466
4o0wADNAurora kinase A2.7.11.10.466
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.465
3pe2E1BCasein kinase II subunit alpha2.7.11.10.465
3sheI85MAP kinase-activated protein kinase 32.7.11.10.465
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.465
1om1IQACasein kinase II subunit alpha2.7.11.10.464
2hog710Serine/threonine-protein kinase Chk12.7.11.10.464
2vttLZDCyclin-dependent kinase 22.7.11.220.464
4anmWULCasein kinase II subunit alpha2.7.11.10.464
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.464
5dosATPAurora kinase A2.7.11.10.464
1m2pHNACasein kinase II subunit alpha2.7.11.10.463
2btrU73Cyclin-dependent kinase 22.7.11.220.463
1dayGNPCasein kinase II subunit alpha2.7.11.10.462
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.462
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.462
5drdATPAurora kinase A2.7.11.10.462
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.461
3q9xEMOCasein kinase II subunit alpha2.7.11.10.461
3qu0X40Cyclin-dependent kinase 22.7.11.220.461
4bgg844Activin receptor type-12.7.11.300.461
4e6d0NUTyrosine-protein kinase JAK2/0.461
4grb0XGCasein kinase II subunit alpha2.7.11.10.461
2pvlP55Casein kinase II subunit alpha2.7.11.10.460
3rkb12ZCyclin-dependent kinase 22.7.11.220.460
5dt3ATPAurora kinase A2.7.11.10.460
2btsU32Cyclin-dependent kinase 22.7.11.220.459
3rmf20ZCyclin-dependent kinase 22.7.11.220.459
1e9hINRCyclin-dependent kinase 22.7.11.220.458
2vtqLZACyclin-dependent kinase 22.7.11.220.458
3rvg17PTyrosine-protein kinase JAK2/0.458
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4btjATPTau-tubulin kinase 12.7.11.10.458
4ji91M3Tyrosine-protein kinase JAK2/0.458
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.458
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.457
4bgh3I6Cyclin-dependent kinase 22.7.11.220.457
1ykr628Cyclin-dependent kinase 22.7.11.220.456
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.456
4fkj11KCyclin-dependent kinase 22.7.11.220.456
4jqeANPCasein kinase II subunit alpha2.7.11.10.456
5e92ANPTGF-beta receptor type-22.7.11.300.456
1w0xOLOCyclin-dependent kinase 22.7.11.220.455
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.455
3rk708ZCyclin-dependent kinase 22.7.11.220.455
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.455
4ix6ADPUncharacterized protein/0.455
2cchATPCyclin-dependent kinase 22.7.11.220.454
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.454
1h1r6CPCyclin-dependent kinase 22.7.11.220.453
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.453
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.453
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.453
1dawANPCasein kinase II subunit alpha2.7.11.10.452
1m2rMNYCasein kinase II subunit alpha2.7.11.10.452
4aqc88ATyrosine-protein kinase JAK2/0.452
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.452
1pxoCK7Cyclin-dependent kinase 22.7.11.220.451
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.451
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.451
2j9mPY8Cyclin-dependent kinase 22.7.11.220.451
2pvmP29Casein kinase II subunit alpha2.7.11.10.451
2y9qANPMitogen-activated protein kinase 12.7.11.240.451
3qtuX44Cyclin-dependent kinase 22.7.11.220.451
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.451
4deeADPAurora kinase A2.7.11.10.451
2dwbANPAurora kinase A2.7.11.10.450
3rpo24ZCyclin-dependent kinase 22.7.11.220.450
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.450
4g170VNCasein kinase I isoform gamma-32.7.11.10.450
4o0sADNAurora kinase A2.7.11.10.450
3le62BZCyclin-dependent kinase 22.7.11.220.449
4ez50RSCyclin-dependent kinase 62.7.11.220.449
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.449
4k33ACPFibroblast growth factor receptor 32.7.10.10.449
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.449
4y93746Tyrosine-protein kinase/0.449
1oiyN41Cyclin-dependent kinase 22.7.11.220.448
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.448
2pmoHMDProtein kinase 7/0.448
2w1fL0FAurora kinase A2.7.11.10.448
2x1nX1NCyclin-dependent kinase 22.7.11.220.448
3iok1P6Tyrosine-protein kinase JAK2/0.448
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.448
4rcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.448
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.447
3qxpX64Cyclin-dependent kinase 22.7.11.220.447
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.447
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.447
4jbpYPHAurora kinase A2.7.11.10.447
1di8DTQCyclin-dependent kinase 22.7.11.220.446
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.446
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.446
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.446
2csnCKICasein kinase I homolog 12.7.11.10.446
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.446
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.446
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.446
4aguD15Cyclin-dependent kinase-like 1/0.446
4aotGW8Serine/threonine-protein kinase 102.7.11.10.446
4f081RSTyrosine-protein kinase JAK2/0.446
1fvv107Cyclin-dependent kinase 22.7.11.220.445
1g5sI17Cyclin-dependent kinase 22.7.11.220.445
1vjy460TGF-beta receptor type-12.7.11.300.445
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.445
3iggEFQCyclin-dependent kinase 22.7.11.220.445
3il1B5DGlutamate receptor 2/0.445
3qtxX43Cyclin-dependent kinase 22.7.11.220.445
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.445
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.445
5dn3ATPAurora kinase A2.7.11.10.445
1oi9N20Cyclin-dependent kinase 22.7.11.220.444
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.444
1pmn984Mitogen-activated protein kinase 102.7.11.240.443
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.443
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3hmm855TGF-beta receptor type-12.7.11.300.443
3nynSGVG protein-coupled receptor kinase 62.7.11.160.443
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4fkt48KCyclin-dependent kinase 22.7.11.220.443
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.443
5dnrATPAurora kinase A2.7.11.10.443
1gii1PUCyclin-dependent kinase 22.7.11.220.442
1ol5ADPAurora kinase A2.7.11.10.442
1u54ACPActivated CDC42 kinase 1/0.442
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.442
2vu3LZECyclin-dependent kinase 22.7.11.220.442
3at4CCKCasein kinase II subunit alpha2.7.11.10.442
3axwTIDCasein kinase II subunit alpha2.7.11.10.442
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3ezrEZRCyclin-dependent kinase 22.7.11.220.442
3sw418KCyclin-dependent kinase 22.7.11.220.442
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.442
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
5dt4ATPAurora kinase A2.7.11.10.442
1pkdUCNCyclin-dependent kinase 22.7.11.220.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.441
3c4zADPRhodopsin kinase/0.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
3rk909ZCyclin-dependent kinase 22.7.11.220.441
3rpv26ZCyclin-dependent kinase 22.7.11.220.441
4fob0USALK tyrosine kinase receptor2.7.10.10.441
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.441
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.441
1lp4ANPCasein kinase II subunit alpha2.7.11.10.440
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.440
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.440
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.440
3gu6ADPDeath-associated protein kinase 12.7.11.10.440
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.440