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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1py5PY1TGF-beta receptor type-12.7.11.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1py5PY1TGF-beta receptor type-12.7.11.301.000
1vjy460TGF-beta receptor type-12.7.11.300.580
2wouZZFTGF-beta receptor type-12.7.11.300.569
4c02TAKActivin receptor type-12.7.11.300.557
2wotZZGTGF-beta receptor type-12.7.11.300.540
1eh4IC1Casein kinase I homolog 12.7.11.10.536
3mtfA3FActivin receptor type-12.7.11.300.531
3hmm855TGF-beta receptor type-12.7.11.300.526
5e8wSTUTGF-beta receptor type-12.7.11.300.514
1rw8580TGF-beta receptor type-12.7.11.300.507
3w33W19Epidermal growth factor receptor2.7.10.10.505
2btsU32Cyclin-dependent kinase 22.7.11.220.500
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.500
3gxlQIGTGF-beta receptor type-12.7.11.300.499
4dymIYZActivin receptor type-12.7.11.300.499
4g160VMCasein kinase I isoform gamma-32.7.11.10.497
4hge15VTyrosine-protein kinase JAK2/0.493
4g170VNCasein kinase I isoform gamma-32.7.11.10.492
1u4dDBQActivated CDC42 kinase 1/0.491
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.491
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.489
2y9qANPMitogen-activated protein kinase 12.7.11.240.489
3w32W32Epidermal growth factor receptor2.7.10.10.488
3lfqA28Cyclin-dependent kinase 22.7.11.220.487
3r83Z14Cyclin-dependent kinase 22.7.11.220.483
2izrBRKCasein kinase I isoform gamma-32.7.11.10.482
5e92ANPTGF-beta receptor type-22.7.11.300.482
3iok1P6Tyrosine-protein kinase JAK2/0.481
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.481
1g5sI17Cyclin-dependent kinase 22.7.11.220.480
1di8DTQCyclin-dependent kinase 22.7.11.220.479
1xkkFMMEpidermal growth factor receptor2.7.10.10.479
2x1nX1NCyclin-dependent kinase 22.7.11.220.479
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.479
4kb81QOCasein kinase I isoform delta2.7.11.10.477
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.476
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.476
1ke6LS2Cyclin-dependent kinase 22.7.11.220.474
1y91CT9Cyclin-dependent kinase 22.7.11.220.473
2btrU73Cyclin-dependent kinase 22.7.11.220.473
4jajXU1Aurora kinase A2.7.11.10.473
1t7j478Gag-Pol polyprotein3.4.23.160.472
4bgg844Activin receptor type-12.7.11.300.472
4hgs15GCasein kinase I isoform gamma-32.7.11.10.472
4ek610KCyclin-dependent kinase 22.7.11.220.471
5cnoANPEpidermal growth factor receptor2.7.10.10.471
3lfnA27Cyclin-dependent kinase 22.7.11.220.470
1h1r6CPCyclin-dependent kinase 22.7.11.220.469
1oirHDYCyclin-dependent kinase 22.7.11.220.469
2b7aIZATyrosine-protein kinase JAK2/0.469
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.469
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.468
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.468
4f650S9Fibroblast growth factor receptor 1/0.468
1h1s4SPCyclin-dependent kinase 22.7.11.220.467
4eon1ROCyclin-dependent kinase 22.7.11.220.467
4jboWPHAurora kinase A2.7.11.10.467
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.466
5cnnANPEpidermal growth factor receptor2.7.10.10.466
3uyt0CKCasein kinase I isoform delta2.7.11.10.465
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.465
4fmqANPMitogen-activated protein kinase 12.7.11.240.465
2eufLQQCyclin-dependent kinase 62.7.11.220.464
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.464
1lf3EH5Plasmepsin-23.4.23.390.463
1m2rMNYCasein kinase II subunit alpha2.7.11.10.463
3orkAGSSerine/threonine protein kinase/0.463
4h3qANPMitogen-activated protein kinase 12.7.11.240.463
1m2pHNACasein kinase II subunit alpha2.7.11.10.462
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.462
3nieANPMitogen-activated protein kinase/0.462
3sheI85MAP kinase-activated protein kinase 32.7.11.10.462
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.462
5e8xSTUTGF-beta receptor type-12.7.11.300.462
2a4lRRCCyclin-dependent kinase 22.7.11.220.461
3oroAGSSerine/threonine protein kinase/0.461
4bcoT6QCyclin-dependent kinase 22.7.11.220.461
5e8ySTUTGF-beta receptor type-22.7.11.300.461
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3nwxKVSGag-Pol polyprotein3.4.23.160.460
4kbk1QGCasein kinase I isoform delta2.7.11.10.460
4otiMI1Serine/threonine-protein kinase N1/0.460
1aq1STUCyclin-dependent kinase 22.7.11.220.459
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.459
2itpAEEEpidermal growth factor receptor2.7.10.10.459
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.459
4dqh017Gag-Pol polyprotein/0.459
4fkpLS5Cyclin-dependent kinase 22.7.11.220.459
1e1xNW1Cyclin-dependent kinase 22.7.11.220.458
1pxlCK4Cyclin-dependent kinase 22.7.11.220.458
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.458
3tkuM77Serine/threonine-protein kinase MRCK beta2.7.11.10.458
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.458
4y93746Tyrosine-protein kinase/0.458
1u54ACPActivated CDC42 kinase 1/0.457
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.457
4fki09KCyclin-dependent kinase 22.7.11.220.457
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3l8p0CEAngiopoietin-1 receptor2.7.10.10.456
4a6bQG8Gag-Pol polyprotein3.4.23.160.456
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.456
4ewhT77Activated CDC42 kinase 1/0.456
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.456
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.456
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.456
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.456
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.455
3rk708ZCyclin-dependent kinase 22.7.11.220.455
1sh9RITGag-Pol polyprotein3.4.23.160.454
3el4ROCGag-Pol polyprotein3.4.23.160.454
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.454
4dqb017Gag-Pol polyprotein/0.454
3eyhIZATyrosine-protein kinase JAK1/0.453
3k5uPFQAurora kinase A2.7.11.10.453
4e4m0NHTyrosine-protein kinase JAK2/0.453
4g3rCAMCamphor 5-monooxygenase1.14.15.10.453
4k33ACPFibroblast growth factor receptor 32.7.10.10.453
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.451
3gu83GUDeath-associated protein kinase 12.7.11.10.451
4a6cQG9Gag-Pol polyprotein3.4.23.160.451
4a8v2ANMajor pollen allergen Bet v 1-J/0.451
4anmWULCasein kinase II subunit alpha2.7.11.10.451
1ke5LS1Cyclin-dependent kinase 22.7.11.220.450
2b52D42Cyclin-dependent kinase 22.7.11.220.450
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.450
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.450
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.450
3le62BZCyclin-dependent kinase 22.7.11.220.450
3qp0NI8Gag-Pol polyprotein3.4.23.160.450
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.449
1pxoCK7Cyclin-dependent kinase 22.7.11.220.449
2fxeDR7Gag-Pol polyprotein3.4.23.160.449
2nnkROCProtease/0.449
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.449
4riyADPEpidermal growth factor receptor2.7.10.10.449
2cen4AHProtease/0.448
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3i2l2NCProtease/0.448
4aqc88ATyrosine-protein kinase JAK2/0.448
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.447
1bxoPP7Penicillopepsin-13.4.23.200.447
1bygSTUTyrosine-protein kinase CSK/0.447
1t85CAMCamphor 5-monooxygenase1.14.15.10.447
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.447
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3tqhNDPQuinone oxidoreductase/0.447
4fkj11KCyclin-dependent kinase 22.7.11.220.447
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.447
1c6yMK1Protease/0.446
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.446
2pvhP19Casein kinase II subunit alpha2.7.11.10.446
2xa4AZ5Tyrosine-protein kinase JAK2/0.446
3eljGS7Mitogen-activated protein kinase 82.7.11.240.446
3ggxGGXGag-Pol polyprotein/0.446
3qpjN4IGag-Pol polyprotein3.4.23.160.446
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.446
4ye3G04Gag-Pol polyprotein3.4.23.160.446
3ggfGVDSerine/threonine-protein kinase 26/0.445
4fkg4CKCyclin-dependent kinase 22.7.11.220.445
4fko20KCyclin-dependent kinase 22.7.11.220.445
4fv6E57Mitogen-activated protein kinase 12.7.11.240.445
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.445
4jq7KJQEpidermal growth factor receptor2.7.10.10.445
1ec3MS3Gag-Pol polyprotein3.4.23.160.444
1sguMK1Gag-Pol polyprotein3.4.23.160.444
2a0cCK9Cyclin-dependent kinase 22.7.11.220.444
2duv371Cyclin-dependent kinase 22.7.11.220.444
2uxzHI1Gag-Pol polyprotein3.4.23.160.444
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.444
4fkt48KCyclin-dependent kinase 22.7.11.220.444
1dz4CAMCamphor 5-monooxygenase1.14.15.10.443
1hiiC20Gag-Pol polyprotein/0.443
1jpaANPEphrin type-B receptor 22.7.10.10.443
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.443
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2r64740Cyclin-dependent kinase 22.7.11.220.443
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.443
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.443
4o0wADNAurora kinase A2.7.11.10.443
1k6cMK1Gag-Pol polyprotein3.4.23.160.442
2bglNAJSecoisolariciresinol dehydrogenase1.1.1.3310.442
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2xmyCDKCyclin-dependent kinase 22.7.11.220.442
2xyfG40Gag-Pol polyprotein/0.442
3cyxROCGag-Pol polyprotein3.4.23.160.442
3efwAK8Aurora kinase A2.7.11.10.442
3el51UNGag-Pol polyprotein/0.442
3litE15Protease/0.442
3nduROCGag-Pol polyprotein3.4.23.160.442
3nxe2NCProtease/0.442
3oxv478Gag-Pol polyprotein3.4.23.160.442
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.442
3r8lZ30Cyclin-dependent kinase 22.7.11.220.442
3rvg17PTyrosine-protein kinase JAK2/0.442
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.442
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
4fklCK2Cyclin-dependent kinase 22.7.11.220.442
4j5j478Gag-Pol polyprotein3.4.23.160.442
4jq8KJ8Epidermal growth factor receptor2.7.10.10.442
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.441
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.441
2fxdDR7Pol polyprotein/0.441
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
2p5uNADUDP-glucose 4-epimerase/0.441
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
2znq401Peroxisome proliferator-activated receptor delta/0.441
3il1B5DGlutamate receptor 2/0.441
3s2pPMUCyclin-dependent kinase 22.7.11.220.441
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4eor4SPCyclin-dependent kinase 22.7.11.220.441
4k4p3TLGag-Pol polyprotein/0.441
4y95746Tyrosine-protein kinase/0.441
5eccNAPDehydrofolate reductase type I/0.441
2vtqLZACyclin-dependent kinase 22.7.11.220.440
3a4vNADNDP-sugar epimerase/0.440
3ddpRC8Cyclin-dependent kinase 22.7.11.220.440
3dk1G05Gag-Pol polyprotein3.4.23.160.440
3r1yX76Cyclin-dependent kinase 22.7.11.220.440
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.440
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4hvh19RTyrosine-protein kinase JAK32.7.10.20.440
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.440