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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pxlCK4Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1pxlCK4Cyclin-dependent kinase 22.7.11.221.000
4ek610KCyclin-dependent kinase 22.7.11.220.571
3lfnA27Cyclin-dependent kinase 22.7.11.220.569
4fkg4CKCyclin-dependent kinase 22.7.11.220.568
2a0cCK9Cyclin-dependent kinase 22.7.11.220.565
1ykr628Cyclin-dependent kinase 22.7.11.220.559
2xmyCDKCyclin-dependent kinase 22.7.11.220.545
4fkt48KCyclin-dependent kinase 22.7.11.220.545
2vv9IM9Cyclin-dependent kinase 22.7.11.220.544
1g5sI17Cyclin-dependent kinase 22.7.11.220.540
1y91CT9Cyclin-dependent kinase 22.7.11.220.540
3r8lZ30Cyclin-dependent kinase 22.7.11.220.538
4fkv61KCyclin-dependent kinase 22.7.11.220.538
3lfqA28Cyclin-dependent kinase 22.7.11.220.537
3rk708ZCyclin-dependent kinase 22.7.11.220.536
2r3jSCJCyclin-dependent kinase 22.7.11.220.531
3rk909ZCyclin-dependent kinase 22.7.11.220.530
4ek816KCyclin-dependent kinase 22.7.11.220.528
4fkj11KCyclin-dependent kinase 22.7.11.220.528
3qu0X40Cyclin-dependent kinase 22.7.11.220.525
2b53D23Cyclin-dependent kinase 22.7.11.220.522
3qzgX67Cyclin-dependent kinase 22.7.11.220.522
1ke5LS1Cyclin-dependent kinase 22.7.11.220.521
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.512
2btrU73Cyclin-dependent kinase 22.7.11.220.511
1oitHDTCyclin-dependent kinase 22.7.11.220.510
3r83Z14Cyclin-dependent kinase 22.7.11.220.510
3rpo24ZCyclin-dependent kinase 22.7.11.220.506
1b38ATPCyclin-dependent kinase 22.7.11.220.503
3iggEFQCyclin-dependent kinase 22.7.11.220.502
3r8vZ62Cyclin-dependent kinase 22.7.11.220.499
1pxoCK7Cyclin-dependent kinase 22.7.11.220.498
2uznC96Cyclin-dependent kinase 22.7.11.220.498
3rni21ZCyclin-dependent kinase 22.7.11.220.498
1oirHDYCyclin-dependent kinase 22.7.11.220.497
3qwjX6ACyclin-dependent kinase 22.7.11.220.497
3rkb12ZCyclin-dependent kinase 22.7.11.220.497
2a4lRRCCyclin-dependent kinase 22.7.11.220.495
2c6o4SPCyclin-dependent kinase 22.7.11.220.495
2uzoC62Cyclin-dependent kinase 22.7.11.220.495
1pxmCK5Cyclin-dependent kinase 22.7.11.220.494
2w1hL0FCyclin-dependent kinase 22.7.11.220.494
4fks46KCyclin-dependent kinase 22.7.11.220.494
1hckATPCyclin-dependent kinase 22.7.11.220.490
1pxpCK8Cyclin-dependent kinase 22.7.11.220.490
3qtxX43Cyclin-dependent kinase 22.7.11.220.490
1w0xOLOCyclin-dependent kinase 22.7.11.220.489
3wblPDYCyclin-dependent kinase 22.7.11.220.488
2w17I19Cyclin-dependent kinase 22.7.11.220.487
3rpy27ZCyclin-dependent kinase 22.7.11.220.487
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.486
3r1yX76Cyclin-dependent kinase 22.7.11.220.485
4bgh3I6Cyclin-dependent kinase 22.7.11.220.483
2vtrLZBCyclin-dependent kinase 22.7.11.220.481
2c6kDT2Cyclin-dependent kinase 22.7.11.220.480
3qqhX0ACyclin-dependent kinase 22.7.11.220.480
1gii1PUCyclin-dependent kinase 22.7.11.220.479
3rpv26ZCyclin-dependent kinase 22.7.11.220.479
1ke7LS3Cyclin-dependent kinase 22.7.11.220.478
2ds11CDCyclin-dependent kinase 22.7.11.220.478
2r3kSCQCyclin-dependent kinase 22.7.11.220.478
3rak03ZCyclin-dependent kinase 22.7.11.220.477
4acm7YGCyclin-dependent kinase 22.7.11.220.476
4fki09KCyclin-dependent kinase 22.7.11.220.476
3qtrX36Cyclin-dependent kinase 22.7.11.220.475
2c6lDT4Cyclin-dependent kinase 22.7.11.220.474
4fkpLS5Cyclin-dependent kinase 22.7.11.220.474
3s2pPMUCyclin-dependent kinase 22.7.11.220.473
3rjc06ZCyclin-dependent kinase 22.7.11.220.471
1w8cN69Cyclin-dependent kinase 22.7.11.220.467
3s1h56ZCyclin-dependent kinase 22.7.11.220.467
1y8yCT7Cyclin-dependent kinase 22.7.11.220.465
2r3lSCWCyclin-dependent kinase 22.7.11.220.465
3qtuX44Cyclin-dependent kinase 22.7.11.220.465
4fkq42KCyclin-dependent kinase 22.7.11.220.465
2vthLZ2Cyclin-dependent kinase 22.7.11.220.463
2w06FRVCyclin-dependent kinase 22.7.11.220.461
3qqlX03Cyclin-dependent kinase 22.7.11.220.461
3r71X86Cyclin-dependent kinase 22.7.11.220.460
2b52D42Cyclin-dependent kinase 22.7.11.220.458
3sw418KCyclin-dependent kinase 22.7.11.220.457
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.456
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.456
3r8pZ46Cyclin-dependent kinase 22.7.11.220.456
2duv371Cyclin-dependent kinase 22.7.11.220.453
1ke6LS2Cyclin-dependent kinase 22.7.11.220.452
1e1xNW1Cyclin-dependent kinase 22.7.11.220.451
1ckpPVBCyclin-dependent kinase 22.7.11.220.450
1pxkCK3Cyclin-dependent kinase 22.7.11.220.449
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.449
4fklCK2Cyclin-dependent kinase 22.7.11.220.449
3fz1B98Cyclin-dependent kinase 22.7.11.220.448
2vtsLZCCyclin-dependent kinase 22.7.11.220.447
3r7yZ04Cyclin-dependent kinase 22.7.11.220.447
4kd11QKCyclin-dependent kinase 22.7.11.220.447
3qxoX65Cyclin-dependent kinase 22.7.11.220.445
3rm618ZCyclin-dependent kinase 22.7.11.220.445
1aq1STUCyclin-dependent kinase 22.7.11.220.444
1pxjCK2Cyclin-dependent kinase 22.7.11.220.444
2btsU32Cyclin-dependent kinase 22.7.11.220.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
1p2a5BNCyclin-dependent kinase 22.7.11.220.443
4jboWPHAurora kinase A2.7.11.10.443
3rmf20ZCyclin-dependent kinase 22.7.11.220.442
1h1s4SPCyclin-dependent kinase 22.7.11.220.441
3nynSGVG protein-coupled receptor kinase 62.7.11.160.441
3pj8404Cyclin-dependent kinase 22.7.11.220.441
3r73X87Cyclin-dependent kinase 22.7.11.220.441
3cgfJNFMitogen-activated protein kinase 102.7.11.240.440
3ezvEZVCyclin-dependent kinase 22.7.11.220.440