sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1pwu | GM6 | Lethal factor | 3.4.24.83 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1pwu | GM6 | Lethal factor | 3.4.24.83 | 1.000 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.516 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.508 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.502 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.501 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.497 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.497 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.492 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.490 | |
| 5c93 | ACP | Two-component system histidine protein kinase | / | 0.489 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.487 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.485 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.483 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.480 | |
| 2emu | SAH | Diphthine synthase | / | 0.479 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.478 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 4n1g | CEI | Obelin | / | 0.478 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.478 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.477 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.477 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.475 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.475 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.475 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.475 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.474 | |
| 4iae | 1DX | Alr2278 protein | / | 0.474 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.473 | |
| 3e6e | DCS | Alanine racemase | / | 0.473 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 4yau | 2AM | NADPH--cytochrome P450 reductase | / | 0.473 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.473 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.472 | |
| 4y6u | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.472 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.471 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.471 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.471 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.470 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.469 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.469 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.468 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.468 | |
| 2xb9 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.468 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.468 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.468 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1sqk | LAR | Actin, alpha skeletal muscle | / | 0.467 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.467 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.467 | |
| 5cyo | GDP | Septin-9 | / | 0.467 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.466 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.465 | |
| 2du2 | FMN | Lactate oxidase | / | 0.465 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.465 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.465 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.465 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.465 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.464 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.464 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.464 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.464 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.464 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.463 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.463 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.463 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.463 | |
| 3lcj | COA | Phosphopantetheine adenylyltransferase | / | 0.463 | |
| 3rdq | DTB | Streptavidin | / | 0.463 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.463 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.463 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.463 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.462 | |
| 2xvw | 9NR | Serum albumin | / | 0.462 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.462 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.462 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 1esv | LAR | Actin, alpha skeletal muscle | / | 0.461 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.461 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.461 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.461 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.461 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.461 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.461 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.461 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.460 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.460 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2j0s | ANP | Eukaryotic initiation factor 4A-III | 3.6.4.13 | 0.460 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.460 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.459 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.459 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.459 | |
| 3e8x | NAP | BH1520 protein | / | 0.459 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.459 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.459 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.458 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.458 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.458 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.458 | |
| 3b9l | AZZ | Serum albumin | / | 0.458 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.458 | |
| 3ld6 | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.458 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.458 | |
| 6gsu | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.458 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.457 | |
| 2dxv | SAH | Diphthine synthase | / | 0.457 | |
| 2emr | SAH | Diphthine synthase | / | 0.457 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.457 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.457 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.457 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.457 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.457 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.457 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.457 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.457 | |
| 1nj5 | P5A | Proline--tRNA ligase | / | 0.456 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.456 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.456 | |
| 2eeq | SAH | Diphthine synthase | / | 0.456 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.456 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.456 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.456 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.456 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.456 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.456 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.456 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.456 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.456 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.456 | |
| 2dsg | SAH | Diphthine synthase | / | 0.455 | |
| 2e8h | SAH | Diphthine synthase | / | 0.455 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.455 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.455 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.455 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.455 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.455 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.455 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.455 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.454 | |
| 3qge | 26F | Genome polyprotein | 2.7.7.48 | 0.454 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.454 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.454 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.454 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.453 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.453 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.453 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 2nr4 | FMN | Conserved protein | / | 0.453 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.453 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.453 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.453 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.453 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4hxy | NDP | Plm1 | / | 0.453 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.453 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.453 | |
| 1fw0 | KAI | Glutamate receptor 2 | / | 0.452 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.452 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.452 | |
| 1xnj | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.452 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.452 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.452 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.452 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.452 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.452 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.452 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 2e15 | SAH | Diphthine synthase | / | 0.451 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.451 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.451 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.451 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.451 | |
| 4xsv | CTP | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.451 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.450 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.450 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.450 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.450 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 2dxw | SAH | Diphthine synthase | / | 0.450 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.450 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.450 | |
| 3td7 | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.450 | |
| 4e2d | FMN | Dehydrogenase | / | 0.450 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.450 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4iah | 1DX | Alr2278 protein | / | 0.450 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.450 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.449 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.449 | |
| 1lke | DOG | Bilin-binding protein | / | 0.449 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2ax4 | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 2.7.1.25 | 0.449 | |
| 2b8v | 3BN | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.449 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.449 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.449 | |
| 2pch | SAH | Diphthine synthase | / | 0.449 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.449 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.449 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.449 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.449 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.449 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.449 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.448 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.448 | |
| 1sdm | ADP | Kinesin heavy chain-like protein | / | 0.448 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.448 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.448 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.448 | |
| 2e7z | MGD | Acetylene hydratase | / | 0.448 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 2p6l | SAH | Diphthine synthase | / | 0.448 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.448 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.448 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3qsa | TA7 | Anthranilate phosphoribosyltransferase | / | 0.448 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.448 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.448 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.447 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.447 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.447 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.447 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.447 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 2owv | SAH | Diphthine synthase | / | 0.447 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.447 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.447 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.447 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.447 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.447 | |
| 3uu1 | 14B | Anthranilate phosphoribosyltransferase | / | 0.447 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.447 | |
| 3wag | TYD | Glycosyltransferase | / | 0.447 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.447 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
| 4nvk | 2NY | Peroxidase | / | 0.447 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.447 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.447 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.446 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.446 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2e16 | SAH | Diphthine synthase | / | 0.446 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.446 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.446 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.446 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.446 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.446 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.446 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.446 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.445 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.445 | |
| 1m8j | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.445 | |
| 1n5q | TNC | ActVA 6 protein | / | 0.445 | |
| 1qru | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.445 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.445 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.445 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2hux | SAH | Diphthine synthase | / | 0.445 | |
| 2jlb | UDM | Uncharacterized protein | / | 0.445 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3eku | CY9 | Actin-5C | / | 0.445 | |
| 3nyr | MLC | Putative fatty acid synthase | / | 0.445 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.445 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.445 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.445 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.445 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.445 | |
| 4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.445 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.444 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.444 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.444 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.444 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2a84 | ATP | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 2egl | SAH | Diphthine synthase | / | 0.444 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.444 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2owu | SAH | Diphthine synthase | / | 0.444 | |
| 2vax | CSC | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.444 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.444 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.444 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.444 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.444 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.444 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.444 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.443 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.443 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.443 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.443 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.443 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.443 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.443 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.443 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.443 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4ku7 | PCG | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.443 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.443 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.443 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.442 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.442 | |
| 1wng | SAH | Diphthine synthase | / | 0.442 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.442 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.442 | |
| 2huv | SAH | Diphthine synthase | / | 0.442 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.442 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.442 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.442 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4guk | P2G | Neuronal calcium sensor 1 | / | 0.442 | |
| 5byl | GCP | Bifunctional AAC/APH | 2.3.1 | 0.442 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.441 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.441 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.441 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2op9 | WR1 | Orf1ab polyprotein | / | 0.441 | |
| 2owf | SAH | Diphthine synthase | / | 0.441 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 3o3j | BB4 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.441 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.441 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.441 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.441 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.440 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.440 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.440 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.440 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.440 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.440 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.440 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.440 | |
| 2pcm | SAH | Diphthine synthase | / | 0.440 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.440 | |
| 2xvv | 9DN | Serum albumin | / | 0.440 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3ojx | FAD | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4ai8 | DZA | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.440 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.440 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.440 | |
| 4in4 | 4ID | Kelch-like ECH-associated protein 1 | / | 0.440 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.440 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.440 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.440 |