Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ove358Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ove358Mitogen-activated protein kinase 14/1.000
3gc7B45Mitogen-activated protein kinase 14/0.589
3zsh469Mitogen-activated protein kinase 14/0.581
3fl4FL4Mitogen-activated protein kinase 14/0.577
3fkoFKOMitogen-activated protein kinase 14/0.563
3hub469Mitogen-activated protein kinase 14/0.561
3fknFKNMitogen-activated protein kinase 14/0.559
1ouy094Mitogen-activated protein kinase 14/0.540
3gc9B45Mitogen-activated protein kinase 112.7.11.240.533
1zzlTZYMitogen-activated protein kinase 14/0.527
1m7qDQOMitogen-activated protein kinase 14/0.525
2gfsPQBMitogen-activated protein kinase 14/0.521
1ouk084Mitogen-activated protein kinase 14/0.520
3itzP66Mitogen-activated protein kinase 14/0.517
3fc152PMitogen-activated protein kinase 14/0.516
3ds6A17Mitogen-activated protein kinase 14/0.514
2yixYIXMitogen-activated protein kinase 14/0.504
3fmmXI2Mitogen-activated protein kinase 14/0.498
1zyjBI5Mitogen-activated protein kinase 14/0.497
3kf7L9GMitogen-activated protein kinase 14/0.497
3flsFLSMitogen-activated protein kinase 14/0.493
3s4qNK0Mitogen-activated protein kinase 14/0.491
3mvl38PMitogen-activated protein kinase 14/0.490
1w7h3IPMitogen-activated protein kinase 14/0.487
3uvqFS8Mitogen-activated protein kinase 14/0.487
3flq891Mitogen-activated protein kinase 14/0.486
3hllI45Mitogen-activated protein kinase 14/0.484
3hp552PMitogen-activated protein kinase 14/0.482
1ywrLI9Mitogen-activated protein kinase 14/0.481
3roc29AMitogen-activated protein kinase 14/0.481
3e92G6AMitogen-activated protein kinase 14/0.479
3w33W19Epidermal growth factor receptor2.7.10.10.477
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.477
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
3uvp048Mitogen-activated protein kinase 14/0.474
1yw2PGJMitogen-activated protein kinase 14/0.473
2itzIREEpidermal growth factor receptor2.7.10.10.473
3iw5DF3Mitogen-activated protein kinase 14/0.471
3obgSB2Mitogen-activated protein kinase 14/0.471
4ewqMWLMitogen-activated protein kinase 14/0.471
2itqITQEpidermal growth factor receptor2.7.10.10.469
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.469
3l8sBFFMitogen-activated protein kinase 14/0.469
4klaCHDFerrochelatase, mitochondrial4.99.1.10.469
4qa0SHHHistone deacetylase 83.5.1.980.469
3flwFLWMitogen-activated protein kinase 14/0.467
4dlj6RGMitogen-activated protein kinase 14/0.467
3dt1P40Mitogen-activated protein kinase 14/0.466
3rinI2OMitogen-activated protein kinase 14/0.466
2jedLG8Protein kinase C theta type2.7.11.130.465
4xxvNAD3-isopropylmalate dehydrogenase/0.464
2ij7TPFMycocyclosin synthase1.14.21.90.463
2zazGK1Mitogen-activated protein kinase 14/0.463
4f640S8Fibroblast growth factor receptor 1/0.463
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
1xddAAYIntegrin alpha-L/0.462
3mpaSB2Mitogen-activated protein kinase 14/0.462
2y6o1N1Ephrin type-A receptor 42.7.10.10.461
4gk2L66Ephrin type-A receptor 32.7.10.10.461
4gk4L90Ephrin type-A receptor 32.7.10.10.461
3fmn530Mitogen-activated protein kinase 14/0.460
4kaoKAOFocal adhesion kinase 12.7.10.20.460
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2z4zSC0Geranylgeranyl pyrophosphate synthase/0.459
2zb0GK3Mitogen-activated protein kinase 14/0.459
3gfeP37Mitogen-activated protein kinase 14/0.459
3iphG11Mitogen-activated protein kinase 14/0.459
3iw6PP0Mitogen-activated protein kinase 14/0.459
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.459
3zsi52PMitogen-activated protein kinase 14/0.459
4eh9IRGMitogen-activated protein kinase 14/0.459
1synF89Thymidylate synthase/0.458
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.458
1u3dFADCryptochrome-1/0.457
2itpAEEEpidermal growth factor receptor2.7.10.10.457
2ittAEEEpidermal growth factor receptor2.7.10.10.457
2z4w749Geranylgeranyl pyrophosphate synthase/0.457
2z4y252Geranylgeranyl pyrophosphate synthase/0.457
3fklFKLMitogen-activated protein kinase 14/0.457
3new3NEMitogen-activated protein kinase 14/0.457
3qiyQI1Botulinum neurotoxin type A3.4.24.690.457
4ia3BIVVitamin D3 receptor A/0.457
4ruoBIVVitamin D3 receptor A/0.457
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
2i0ePDSProtein kinase C beta type2.7.11.130.456
4j97ACPFibroblast growth factor receptor 2/0.456
1bl6SB6Mitogen-activated protein kinase 14/0.455
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.455
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.455
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3lxiCAMCytochrome P450/0.455
3uleC69Actin-related protein 3/0.455
4f630S7Fibroblast growth factor receptor 1/0.455
1pr5TBNPurine nucleoside phosphorylase DeoD-type/0.454
3c3eFO12-phospho-L-lactate transferase/0.454
4aa4QC0Mitogen-activated protein kinase 14/0.454
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.453
2w6zL21Biotin carboxylase6.3.4.140.453
3fmlFMLMitogen-activated protein kinase 14/0.453
3pp1IZGDual specificity mitogen-activated protein kinase kinase 12.7.12.20.453
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.453
3bv2P38Mitogen-activated protein kinase 14/0.452
3uibSB2Putative mitogen-activated protein kinase/0.452
3vrwYS5Vitamin D3 receptor/0.452
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.452
4cd2FOLDihydrofolate reductase1.5.1.30.452
4nfn2KCTau-tubulin kinase 12.7.11.10.452
4nks2M2Fibroblast growth factor receptor 1/0.452
1onpFOM1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.451
2w6qOA5Biotin carboxylase6.3.4.140.451
3lfcZ86Mitogen-activated protein kinase 14/0.451
3lfeZ84Mitogen-activated protein kinase 14/0.451
2zbaZBATrichothecene 3-O-acetyltransferase/0.450
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.450
1pydTDPPyruvate decarboxylase isozyme 1/0.449
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.449
2pvyACPFibroblast growth factor receptor 2/0.449
3bx5304Mitogen-activated protein kinase 14/0.449
3h18PMSEsterase/lipase/0.449
3p6pA6BCamphor 5-monooxygenase1.14.15.10.449
4ia7BIVVitamin D3 receptor A/0.449
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.449
1i9c5ADGlutamate mutase epsilon subunit/0.448
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.448
1yinCM3Estrogen receptor/0.448
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.448
4nka2K7Fibroblast growth factor receptor 1/0.448
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3fln3FNMitogen-activated protein kinase 14/0.447
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3nww3NWMitogen-activated protein kinase 14/0.447
4ansVGHALK tyrosine kinase receptor2.7.10.10.447
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4jrvKJVEpidermal growth factor receptor2.7.10.10.447
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4xivACPChemotaxis protein CheA2.7.13.30.447
3hl7I47Mitogen-activated protein kinase 14/0.446
3o8tBMUMitogen-activated protein kinase 14/0.446
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.446
4ol0GTPGTP-binding nuclear protein Ran/0.446
4twpAXITyrosine-protein kinase ABL12.7.10.20.446
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.446
1yqj6NPMitogen-activated protein kinase 14/0.445
2giuFBREstrogen receptor beta/0.445
2zymACXPeriplasmic binding protein/0.445
3c5uP41Mitogen-activated protein kinase 14/0.445
4aacAAVMitogen-activated protein kinase 14/0.445
4g090VDHistidinol dehydrogenase/0.445
1lriCLRBeta-elicitin cryptogein/0.444
3nr4PYVAbscisic acid receptor PYL2/0.444
3vt8YI3Vitamin D3 receptor/0.444
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.444
2a7r5GPGMP reductase 2/0.443
2j5xGSPADP-ribosylation factor 6/0.443
2of2547Tyrosine-protein kinase Lck2.7.10.20.443
2of4979Tyrosine-protein kinase Lck2.7.10.20.443
2zb45OPProstaglandin reductase 21.3.1.480.443
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.443
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
3vtbTKAVitamin D3 receptor/0.443
3w8wFADPutative FAD-dependent oxygenase EncM/0.443
4at0FADPossible succinate dehydrogenase/0.443
4eh60ONMitogen-activated protein kinase 14/0.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4h9753SDihydrofolate reductase1.5.1.30.443
4k9yK9YFocal adhesion kinase 12.7.10.20.443
4rupH97Vitamin D3 receptor A/0.443
1iwjCAMCamphor 5-monooxygenase1.14.15.10.442
2qe4JJ3Estrogen receptor/0.442
3mvm39PMitogen-activated protein kinase 14/0.442
3opdHIEHeat shock protein 83/0.442
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.442
1rf9DBRCamphor 5-monooxygenase1.14.15.10.441
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
2zb1GK4Mitogen-activated protein kinase 14/0.441
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.441
3nmpPYVAbscisic acid receptor PYL2/0.441
3vetADPnebramycin 5' synthase6.1.2.20.441
3vtcTK3Vitamin D3 receptor/0.441
4anqVGHALK tyrosine kinase receptor2.7.10.10.441
5dhhDGWNociceptin receptor/0.441
3uzcT4EAdenosine receptor A2a/0.441
1m17AQ4Epidermal growth factor receptor2.7.10.10.440
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.440
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.440
1umlFR4Adenosine deaminase3.5.4.40.440
1yrdCAMCamphor 5-monooxygenase1.14.15.10.440
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2x7gPVBSRSF protein kinase 22.7.11.10.440
3a0iAJIGlucokinase2.7.1.20.440
3r71X86Cyclin-dependent kinase 22.7.11.220.440
4dc0NDPPutative ketoacyl reductase1.3.10.440
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4eh70OOMitogen-activated protein kinase 14/0.440
4ia1BIVVitamin D3 receptor A/0.440
4ia2BIVVitamin D3 receptor A/0.440