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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ouy094Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ouy094Mitogen-activated protein kinase 14/1.000
1ouk084Mitogen-activated protein kinase 14/0.579
1m7qDQOMitogen-activated protein kinase 14/0.552
3gc7B45Mitogen-activated protein kinase 14/0.550
3fc152PMitogen-activated protein kinase 14/0.545
3uvqFS8Mitogen-activated protein kinase 14/0.544
1ove358Mitogen-activated protein kinase 14/0.542
3o8tBMUMitogen-activated protein kinase 14/0.531
1zyjBI5Mitogen-activated protein kinase 14/0.528
3fmn530Mitogen-activated protein kinase 14/0.525
3hp552PMitogen-activated protein kinase 14/0.525
3flyFLYMitogen-activated protein kinase 14/0.523
3kf7L9GMitogen-activated protein kinase 14/0.520
4eh50OMMitogen-activated protein kinase 14/0.519
2zb0GK3Mitogen-activated protein kinase 14/0.517
4dlj6RGMitogen-activated protein kinase 14/0.508
1bl6SB6Mitogen-activated protein kinase 14/0.507
1ywrLI9Mitogen-activated protein kinase 14/0.507
3uvp048Mitogen-activated protein kinase 14/0.507
3l8sBFFMitogen-activated protein kinase 14/0.503
3gc9B45Mitogen-activated protein kinase 112.7.11.240.502
3roc29AMitogen-activated protein kinase 14/0.498
4eh70OOMitogen-activated protein kinase 14/0.498
3fl4FL4Mitogen-activated protein kinase 14/0.497
3flzFLZMitogen-activated protein kinase 14/0.495
1k6tXN1Gag-Pol polyprotein3.4.23.160.494
3fmh533Mitogen-activated protein kinase 14/0.493
3hllI45Mitogen-activated protein kinase 14/0.493
3iw5DF3Mitogen-activated protein kinase 14/0.492
3mvl38PMitogen-activated protein kinase 14/0.492
3dt1P40Mitogen-activated protein kinase 14/0.491
3mpaSB2Mitogen-activated protein kinase 14/0.491
3fmjFMJMitogen-activated protein kinase 14/0.490
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.490
3gfeP37Mitogen-activated protein kinase 14/0.489
3flsFLSMitogen-activated protein kinase 14/0.488
3iphG11Mitogen-activated protein kinase 14/0.488
3hub469Mitogen-activated protein kinase 14/0.485
3s4qNK0Mitogen-activated protein kinase 14/0.485
1zz2B11Mitogen-activated protein kinase 14/0.481
3iw6PP0Mitogen-activated protein kinase 14/0.481
3fkoFKOMitogen-activated protein kinase 14/0.480
3oc1BMUMitogen-activated protein kinase 14/0.480
4nka2K7Fibroblast growth factor receptor 1/0.479
1zzlTZYMitogen-activated protein kinase 14/0.478
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.478
1k6cMK1Gag-Pol polyprotein3.4.23.160.477
3fi4FI4Mitogen-activated protein kinase 14/0.477
2itqITQEpidermal growth factor receptor2.7.10.10.476
3fmlFMLMitogen-activated protein kinase 14/0.476
3ha85JZMitogen-activated protein kinase 14/0.476
1k6pXN3Gag-Pol polyprotein3.4.23.160.474
3itzP66Mitogen-activated protein kinase 14/0.474
4j1tNADNAD/NADP transhydrogenase alpha subunit 1/0.474
2rg6287Mitogen-activated protein kinase 14/0.471
2zazGK1Mitogen-activated protein kinase 14/0.471
3fln3FNMitogen-activated protein kinase 14/0.471
3fsfFSSMitogen-activated protein kinase 14/0.471
4f640S8Fibroblast growth factor receptor 1/0.471
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.468
2itzIREEpidermal growth factor receptor2.7.10.10.468
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
2ewaSB2Mitogen-activated protein kinase 14/0.467
4ib4ERM5-hydroxytryptamine receptor 2B/0.467
4eh60ONMitogen-activated protein kinase 14/0.466
1nooCAHCamphor 5-monooxygenase1.14.15.10.465
2yixYIXMitogen-activated protein kinase 14/0.465
3ds6A17Mitogen-activated protein kinase 14/0.465
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.464
3wrlCAMCamphor 5-monooxygenase1.14.15.10.464
4bcqTJFCyclin-dependent kinase 22.7.11.220.464
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.464
1yw2PGJMitogen-activated protein kinase 14/0.463
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.463
3hl7I47Mitogen-activated protein kinase 14/0.463
3zsh469Mitogen-activated protein kinase 14/0.463
4eh3NARMitogen-activated protein kinase 14/0.463
3bv2P38Mitogen-activated protein kinase 14/0.462
4r20AERCytochrome P450 family 17 polypeptide 2/0.462
1bl7SB4Mitogen-activated protein kinase 14/0.461
2balPQAMitogen-activated protein kinase 14/0.461
3fmmXI2Mitogen-activated protein kinase 14/0.460
3mvm39PMitogen-activated protein kinase 14/0.460
3uibSB2Putative mitogen-activated protein kinase/0.458
2vzmNRBCytochrome P450 monooxygenase PikC/0.457
2ghlLIBMitogen-activated protein kinase 14/0.456
4tuvCPZCytochrome P450 1191.140.456
3l8xN4DMitogen-activated protein kinase 14/0.455
3obgSB2Mitogen-activated protein kinase 14/0.455
3flq891Mitogen-activated protein kinase 14/0.454
3nww3NWMitogen-activated protein kinase 14/0.454
4aa5NQBMitogen-activated protein kinase 14/0.454
2cig1DGDihydrofolate reductase1.5.1.30.453
2i0ePDSProtein kinase C beta type2.7.11.130.453
3h0sB38Acetyl-CoA carboxylase/0.453
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.453
1t85CAMCamphor 5-monooxygenase1.14.15.10.452
2itwITQEpidermal growth factor receptor2.7.10.10.452
3mdvCL6Cholesterol 24-hydroxylase/0.452
1m17AQ4Epidermal growth factor receptor2.7.10.10.451
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.451
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
1kzjCB3Thymidylate synthase/0.450
4eym0RXMitogen-activated protein kinase 132.7.11.240.450
4iebANPCalmodulin-domain protein kinase 1/0.450
2ittAEEEpidermal growth factor receptor2.7.10.10.449
3w2o03PEpidermal growth factor receptor2.7.10.10.448
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4jrvKJVEpidermal growth factor receptor2.7.10.10.448
1w84L12Mitogen-activated protein kinase 14/0.447
2a1nCAMCamphor 5-monooxygenase1.14.15.10.447
4lxhC1EAlpha/beta hydrolase fold/0.447
2b1pAIZMitogen-activated protein kinase 102.7.11.240.446
2zb1GK4Mitogen-activated protein kinase 14/0.446
2znpK55Peroxisome proliferator-activated receptor delta/0.446
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.446
4f630S7Fibroblast growth factor receptor 1/0.446
4j97ACPFibroblast growth factor receptor 2/0.446
4nfn2KCTau-tubulin kinase 12.7.11.10.446
4nks2M2Fibroblast growth factor receptor 1/0.446
1iwjCAMCamphor 5-monooxygenase1.14.15.10.445
2j0k4STFocal adhesion kinase 12.7.10.20.445
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2po7CHDFerrochelatase, mitochondrial4.99.1.10.444
3fwjCAMCamphor 5-monooxygenase1.14.15.10.444
3wrhCAMCamphor 5-monooxygenase1.14.15.10.444
4anqVGHALK tyrosine kinase receptor2.7.10.10.444
1phgMYTCamphor 5-monooxygenase1.14.15.10.443
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.443
2y6o1N1Ephrin type-A receptor 42.7.10.10.443
4l4aCAMCamphor 5-monooxygenase1.14.15.10.443
1iwiCAMCamphor 5-monooxygenase1.14.15.10.442
1k6vXN2Gag-Pol polyprotein3.4.23.160.442
1uyuCAMCamphor 5-monooxygenase1.14.15.10.442
1yrcCAMCamphor 5-monooxygenase1.14.15.10.442
2x7gPVBSRSF protein kinase 22.7.11.10.442
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4aacAAVMitogen-activated protein kinase 14/0.442
4g3rCAMCamphor 5-monooxygenase1.14.15.10.442
4hyu1BKMitogen-activated protein kinase 82.7.11.240.442
2eauCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
3fwfCAMCamphor 5-monooxygenase1.14.15.10.441
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4c9oCAMCytochrome P450/0.441
4enhFVXCholesterol 24-hydroxylase/0.441
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.441
2qd9LGFMitogen-activated protein kinase 14/0.440
2z97CAMCamphor 5-monooxygenase1.14.15.10.440
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4l4cCAMCamphor 5-monooxygenase1.14.15.10.440
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.440