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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1oirHDYCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1oirHDYCyclin-dependent kinase 22.7.11.221.000
3lfqA28Cyclin-dependent kinase 22.7.11.220.606
4ek816KCyclin-dependent kinase 22.7.11.220.592
3le62BZCyclin-dependent kinase 22.7.11.220.574
1y91CT9Cyclin-dependent kinase 22.7.11.220.571
1aq1STUCyclin-dependent kinase 22.7.11.220.567
3r83Z14Cyclin-dependent kinase 22.7.11.220.566
4fklCK2Cyclin-dependent kinase 22.7.11.220.566
4fkg4CKCyclin-dependent kinase 22.7.11.220.558
1ykr628Cyclin-dependent kinase 22.7.11.220.555
1oitHDTCyclin-dependent kinase 22.7.11.220.548
2r3jSCJCyclin-dependent kinase 22.7.11.220.546
1w8cN69Cyclin-dependent kinase 22.7.11.220.545
3qqlX03Cyclin-dependent kinase 22.7.11.220.536
3lfnA27Cyclin-dependent kinase 22.7.11.220.534
4fkt48KCyclin-dependent kinase 22.7.11.220.533
4ek610KCyclin-dependent kinase 22.7.11.220.532
2c6o4SPCyclin-dependent kinase 22.7.11.220.530
2a0cCK9Cyclin-dependent kinase 22.7.11.220.528
3iggEFQCyclin-dependent kinase 22.7.11.220.527
4fki09KCyclin-dependent kinase 22.7.11.220.525
2a4lRRCCyclin-dependent kinase 22.7.11.220.524
1b38ATPCyclin-dependent kinase 22.7.11.220.523
4fkpLS5Cyclin-dependent kinase 22.7.11.220.520
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.515
2b53D23Cyclin-dependent kinase 22.7.11.220.514
3r7yZ04Cyclin-dependent kinase 22.7.11.220.512
2w06FRVCyclin-dependent kinase 22.7.11.220.509
1pxlCK4Cyclin-dependent kinase 22.7.11.220.507
2exmZIPCyclin-dependent kinase 22.7.11.220.503
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.502
3qzgX67Cyclin-dependent kinase 22.7.11.220.500
3r8lZ30Cyclin-dependent kinase 22.7.11.220.500
1e1xNW1Cyclin-dependent kinase 22.7.11.220.498
4fkq42KCyclin-dependent kinase 22.7.11.220.497
3r1yX76Cyclin-dependent kinase 22.7.11.220.496
3s2pPMUCyclin-dependent kinase 22.7.11.220.495
2uznC96Cyclin-dependent kinase 22.7.11.220.494
3rk708ZCyclin-dependent kinase 22.7.11.220.494
4fkj11KCyclin-dependent kinase 22.7.11.220.494
2btsU32Cyclin-dependent kinase 22.7.11.220.493
3rni21ZCyclin-dependent kinase 22.7.11.220.491
2xmyCDKCyclin-dependent kinase 22.7.11.220.490
3wblPDYCyclin-dependent kinase 22.7.11.220.490
2vthLZ2Cyclin-dependent kinase 22.7.11.220.488
2uzoC62Cyclin-dependent kinase 22.7.11.220.487
4fkv61KCyclin-dependent kinase 22.7.11.220.487
4fks46KCyclin-dependent kinase 22.7.11.220.486
1y8yCT7Cyclin-dependent kinase 22.7.11.220.484
2c6kDT2Cyclin-dependent kinase 22.7.11.220.484
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.484
1pxmCK5Cyclin-dependent kinase 22.7.11.220.483
2w1hL0FCyclin-dependent kinase 22.7.11.220.483
4acm7YGCyclin-dependent kinase 22.7.11.220.483
1gii1PUCyclin-dependent kinase 22.7.11.220.482
2ds11CDCyclin-dependent kinase 22.7.11.220.482
1ke5LS1Cyclin-dependent kinase 22.7.11.220.478
1w0xOLOCyclin-dependent kinase 22.7.11.220.478
2c6lDT4Cyclin-dependent kinase 22.7.11.220.478
1pxoCK7Cyclin-dependent kinase 22.7.11.220.477
2x1nX1NCyclin-dependent kinase 22.7.11.220.477
2btrU73Cyclin-dependent kinase 22.7.11.220.476
1h1s4SPCyclin-dependent kinase 22.7.11.220.474
3r8vZ62Cyclin-dependent kinase 22.7.11.220.474
3r8pZ46Cyclin-dependent kinase 22.7.11.220.472
3qu0X40Cyclin-dependent kinase 22.7.11.220.471
2c5yMTWCyclin-dependent kinase 22.7.11.220.470
3qwjX6ACyclin-dependent kinase 22.7.11.220.469
3s1h56ZCyclin-dependent kinase 22.7.11.220.469
3sw719KCyclin-dependent kinase 22.7.11.220.469
2w17I19Cyclin-dependent kinase 22.7.11.220.465
1hckATPCyclin-dependent kinase 22.7.11.220.464
3rpo24ZCyclin-dependent kinase 22.7.11.220.463
1g5sI17Cyclin-dependent kinase 22.7.11.220.461
2duv371Cyclin-dependent kinase 22.7.11.220.460
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.460
2vtsLZCCyclin-dependent kinase 22.7.11.220.460
2b52D42Cyclin-dependent kinase 22.7.11.220.459
1ke7LS3Cyclin-dependent kinase 22.7.11.220.458
3ezvEZVCyclin-dependent kinase 22.7.11.220.457
3r1sX73Cyclin-dependent kinase 22.7.11.220.457
4eon1ROCyclin-dependent kinase 22.7.11.220.457
3rmf20ZCyclin-dependent kinase 22.7.11.220.456
4kd11QKCyclin-dependent kinase 22.7.11.220.456
3rk909ZCyclin-dependent kinase 22.7.11.220.455
3r9dX6BCyclin-dependent kinase 22.7.11.220.454
3rahO1ZCyclin-dependent kinase 22.7.11.220.454
3rk507ZCyclin-dependent kinase 22.7.11.220.454
3rkb12ZCyclin-dependent kinase 22.7.11.220.454
2r3iSCFCyclin-dependent kinase 22.7.11.220.453
2vu3LZECyclin-dependent kinase 22.7.11.220.453
2vv9IM9Cyclin-dependent kinase 22.7.11.220.452
3sheI85MAP kinase-activated protein kinase 32.7.11.10.451
1ckpPVBCyclin-dependent kinase 22.7.11.220.450
3nynSGVG protein-coupled receptor kinase 62.7.11.160.450
3pj8404Cyclin-dependent kinase 22.7.11.220.450
4bgh3I6Cyclin-dependent kinase 22.7.11.220.450
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
3ezrEZRCyclin-dependent kinase 22.7.11.220.449
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.449
1pxpCK8Cyclin-dependent kinase 22.7.11.220.448
2c5nCK8Cyclin-dependent kinase 22.7.11.220.448
3lfsA07Cyclin-dependent kinase 22.7.11.220.448
2vtrLZBCyclin-dependent kinase 22.7.11.220.447
3qxoX65Cyclin-dependent kinase 22.7.11.220.446
3qxpX64Cyclin-dependent kinase 22.7.11.220.446
3r7vZ02Cyclin-dependent kinase 22.7.11.220.446
3ral04ZCyclin-dependent kinase 22.7.11.220.446
4bcoT6QCyclin-dependent kinase 22.7.11.220.445
1vjy460TGF-beta receptor type-12.7.11.300.444
3rjc06ZCyclin-dependent kinase 22.7.11.220.444
3sqq99ZCyclin-dependent kinase 22.7.11.220.444
3qtxX43Cyclin-dependent kinase 22.7.11.220.443
3r71X86Cyclin-dependent kinase 22.7.11.220.443
1urwI1PCyclin-dependent kinase 22.7.11.220.441
3hmm855TGF-beta receptor type-12.7.11.300.441
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
3qtzX42Cyclin-dependent kinase 22.7.11.220.440
3r7uX96Cyclin-dependent kinase 22.7.11.220.440