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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1oaaNAPSepiapterin reductase1.1.1.153

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1oaaNAPSepiapterin reductase1.1.1.1531.000
4j7uNAPSepiapterin reductase1.1.1.1530.613
4j7xNAPSepiapterin reductase1.1.1.1530.610
4hwkNAPSepiapterin reductase1.1.1.1530.590
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.491
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.489
1xg5NAPDehydrogenase/reductase SDR family member 11/0.476
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.475
5idwNAPShort-chain dehydrogenase/reductase SDR/0.475
3l77NJPShort-chain alcohol dehydrogenase/0.467
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.466
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.464
2bd0NAPSepiapterin reductase/0.463
1n5dNDPCarbonyl reductase [NADPH] 1/0.460
3p19NDPPutative blue fluorescent protein/0.460
1ipeNDPTropinone reductase 21.1.1.2360.459
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.456
4bmvNAPShort-chain dehydrogenase/0.456
2yutNAPPutative short-chain oxidoreductase/0.453
1snyNAPLD36273p/0.451
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.451
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.440
3f1kNAPUncharacterized oxidoreductase YciK10.440