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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.581.000
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.663
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.663
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.652
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.618
1s63778Protein farnesyltransferase subunit beta2.5.1.580.611
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.611
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.605
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.597
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.591
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.591
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.590
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.585
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.583
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.570
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.561
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.552
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.543
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.539
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.529
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.501
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.496
3q7fED2Uncharacterized protein/0.486
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.475
3sfy3FYUncharacterized protein/0.465
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.454
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.448