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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1njcDCMThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1njcDCMThymidylate synthase/1.000
1thyUMPThymidylate synthase/0.710
1njaDCMThymidylate synthase/0.616
1njdUMPThymidylate synthase/0.614
1jmfUMPThymidylate synthase/0.586
1tsyUMPThymidylate synthase/0.584
2g86UMPThymidylate synthase/0.583
2g89UMPThymidylate synthase/0.578
1jmgUMPThymidylate synthase/0.576
1njbUMPThymidylate synthase/0.575
1njeDCMThymidylate synthase/0.572
1bp6UMPThymidylate synthase/0.564
1vzaUMPThymidylate synthase/0.541
1bp0UMPThymidylate synthase/0.540
1tsxUMPThymidylate synthase/0.521
1lcbTMPThymidylate synthase/0.509
1lcbDHFThymidylate synthase/0.508
1jmiUMPThymidylate synthase/0.504
1vzbUMPThymidylate synthase/0.482
2g8aUMPThymidylate synthase/0.477
4einNOHThymidylate synthase2.1.1.450.474
1tsvUMPThymidylate synthase/0.462
1jmhUMPThymidylate synthase/0.456
2g8dUMPThymidylate synthase/0.452
2tdmUMPThymidylate synthase/0.441
2tddTHFThymidylate synthase/0.440