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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.581.000
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.779
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.727
1s63778Protein farnesyltransferase subunit beta2.5.1.580.685
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.677
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.658
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.657
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.645
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.641
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.624
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.620
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.616
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.610
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.608
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.608
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.604
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.593
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.569
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.548
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.519
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.515
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.513
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.484
3q7fED2Uncharacterized protein/0.475
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.474
3sfy3FYUncharacterized protein/0.467
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.460
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.455
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.455
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.452
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.445
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.580.442