Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mqbANPEphrin type-A receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1mqbANPEphrin type-A receptor 22.7.10.11.000
2henADPEphrin type-B receptor 22.7.10.10.539
2qoqANPEphrin type-A receptor 32.7.10.10.536
4k8aK8AFocal adhesion kinase 12.7.10.20.524
2qo7ANPEphrin type-A receptor 32.7.10.10.516
3zewSTUEphrin type-B receptor 42.7.10.10.511
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.506
4gk4L90Ephrin type-A receptor 32.7.10.10.504
2xvdAS6Ephrin type-B receptor 42.7.10.10.503
2x9fX9FEphrin type-B receptor 42.7.10.10.502
2ijmATPFocal adhesion kinase 12.7.10.20.499
4c3pACPAurora kinase A2.7.11.10.491
4gu94GUFocal adhesion kinase 12.7.10.20.490
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.489
4qmlANPSerine/threonine-protein kinase 242.7.11.10.486
2vwu7X1Ephrin type-B receptor 42.7.10.10.484
3a7hATPSerine/threonine-protein kinase 242.7.11.10.483
3d7tSTUTyrosine-protein kinase CSK/0.482
4jia1K3Tyrosine-protein kinase JAK2/0.482
2j0lANPFocal adhesion kinase 12.7.10.20.479
2qocANPEphrin type-A receptor 32.7.10.10.476
3t8oATPRhodopsin kinase/0.474
2etm7PYFocal adhesion kinase 12.7.10.20.472
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
4gmy0X5Tyrosine-protein kinase JAK2/0.469
1i44ACPInsulin receptor2.7.10.10.468
2ijmADPFocal adhesion kinase 12.7.10.20.468
2v7a627Tyrosine-protein kinase ABL12.7.10.20.468
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.467
4j99ACPFibroblast growth factor receptor 2/0.467
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.467
2j0m4STFocal adhesion kinase 12.7.10.20.466
3my5RFZCyclin-dependent kinase 22.7.11.220.465
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.465
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.464
3vjoANPEpidermal growth factor receptor2.7.10.10.464
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.463
4j95ACPFibroblast growth factor receptor 2/0.462
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.461
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.459
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.459
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.458
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.457
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.456
2ojj82AMitogen-activated protein kinase 12.7.11.240.456
3w2o03PEpidermal growth factor receptor2.7.10.10.456
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.455
4gk2L66Ephrin type-A receptor 32.7.10.10.454
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.452
3pxkPXKFocal adhesion kinase 12.7.10.20.452
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.452
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.452
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2qo9ANPEphrin type-A receptor 32.7.10.10.451
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.451
4o0uADNAurora kinase A2.7.11.10.451
4aguD15Cyclin-dependent kinase-like 1/0.450
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.450
2wqeADPAurora kinase A2.7.11.10.449
4gk3L87Ephrin type-A receptor 32.7.10.10.449
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.447
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.447
2of2547Tyrosine-protein kinase Lck2.7.10.20.446
3c4xATPRhodopsin kinase/0.446
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.446
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.445
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.445
4b99R4LMitogen-activated protein kinase 72.7.11.240.445
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.444
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.444
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.443
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.443
2j7t274Serine/threonine-protein kinase 102.7.11.10.443
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.443
5aaaVGHALK tyrosine kinase receptor2.7.10.10.443
2yn8STUEphrin type-B receptor 42.7.10.10.442
4grb0XGCasein kinase II subunit alpha2.7.11.10.442
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.442
1bygSTUTyrosine-protein kinase CSK/0.441
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.440
2w1fL0FAurora kinase A2.7.11.10.440
4qo9627Serine/threonine-protein kinase 242.7.11.10.440