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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mq4ADPAurora kinase A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1mq4ADPAurora kinase A2.7.11.11.000
5drdATPAurora kinase A2.7.11.10.625
2dwbANPAurora kinase A2.7.11.10.611
4jajXU1Aurora kinase A2.7.11.10.593
5dt3ATPAurora kinase A2.7.11.10.586
3k5uPFQAurora kinase A2.7.11.10.582
5dn3ATPAurora kinase A2.7.11.10.579
4o0wADNAurora kinase A2.7.11.10.574
5dt4ATPAurora kinase A2.7.11.10.574
4jbpYPHAurora kinase A2.7.11.10.573
2np8CC3Aurora kinase A2.7.11.10.572
1ol7ADPAurora kinase A2.7.11.10.569
1ol5ADPAurora kinase A2.7.11.10.565
3efwAK8Aurora kinase A2.7.11.10.563
5dnrATPAurora kinase A2.7.11.10.560
5dosATPAurora kinase A2.7.11.10.560
2xru400Aurora kinase A2.7.11.10.556
5dr2ATPAurora kinase A2.7.11.10.550
5dr9SKEAurora kinase A2.7.11.10.549
2w1fL0FAurora kinase A2.7.11.10.547
4deaNHIAurora kinase A2.7.11.10.545
4o0sADNAurora kinase A2.7.11.10.542
3w16P9JAurora kinase A2.7.11.10.529
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.528
2w1gL0GAurora kinase A2.7.11.10.525
3w2cN15Aurora kinase A2.7.11.10.522
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.521
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.520
4c3rACPAurora kinase A2.7.11.10.518
3uo50BXAurora kinase A2.7.11.10.517
3w18N13Aurora kinase A2.7.11.10.517
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.514
5dr6SKEAurora kinase A2.7.11.10.512
5dpvSKEAurora kinase A2.7.11.10.509
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.503
3c4zADPRhodopsin kinase/0.501
4utdACPAurora kinase A2.7.11.10.501
3c50ADPRhodopsin kinase/0.497
4cegADPAurora kinase A2.7.11.10.497
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.495
2xneASHAurora kinase A2.7.11.10.494
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.492
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.490
2r38G4GGag-Pol polyprotein3.4.23.160.488
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.488
1h1r6CPCyclin-dependent kinase 22.7.11.220.487
2pmoHMDProtein kinase 7/0.485
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.485
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.485
2x1nX1NCyclin-dependent kinase 22.7.11.220.484
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.483
4dgo0JWCasein kinase II subunit alpha2.7.11.10.483
5dt0SKEAurora kinase A2.7.11.10.483
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.482
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.481
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.481
2j4z626Aurora kinase A2.7.11.10.479
3a7jADPSerine/threonine-protein kinase 242.7.11.10.478
4jbqVX6Aurora kinase A2.7.11.10.478
2xngA0HAurora kinase A2.7.11.10.477
1u4dDBQActivated CDC42 kinase 1/0.476
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.476
3oroAGSSerine/threonine protein kinase/0.476
1di8DTQCyclin-dependent kinase 22.7.11.220.475
2pvnP63Casein kinase II subunit alpha2.7.11.10.475
2x6dX6DAurora kinase A2.7.11.10.475
1oiuN76Cyclin-dependent kinase 22.7.11.220.474
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.474
1vyw292Cyclin-dependent kinase 22.7.11.220.473
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.473
2r3tG4GGag-Pol polyprotein3.4.23.160.473
3ddpRC8Cyclin-dependent kinase 22.7.11.220.472
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.472
4c02TAKActivin receptor type-12.7.11.300.472
2j9mPY8Cyclin-dependent kinase 22.7.11.220.471
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.470
1rfuADPPyridoxal kinase2.7.1.350.469
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.469
2w1eL0EAurora kinase A2.7.11.10.468
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.468
5e8wSTUTGF-beta receptor type-12.7.11.300.468
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.467
3qihFG7Gag-Pol polyprotein3.4.23.160.467
1lp4ANPCasein kinase II subunit alpha2.7.11.10.466
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.466
2pvhP19Casein kinase II subunit alpha2.7.11.10.466
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.466
4fv6E57Mitogen-activated protein kinase 12.7.11.240.466
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.465
2w1dL0DAurora kinase A2.7.11.10.465
2xikJ60Serine/threonine-protein kinase 252.7.11.10.465
3tjsD0RCytochrome P450 3A4/0.465
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.465
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.465
4aotGW8Serine/threonine-protein kinase 102.7.11.10.464
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.464
4nifANPMitogen-activated protein kinase 12.7.11.240.464
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.463
3c4wATPRhodopsin kinase/0.462
3ea4FABAcetolactate synthase, chloroplastic2.2.1.60.462
3ekx1UNGag-Pol polyprotein3.4.23.160.462
1zeoC01Peroxisome proliferator-activated receptor gamma/0.461
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.461
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.461
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.461
4gmy0X5Tyrosine-protein kinase JAK2/0.461
1m2pHNACasein kinase II subunit alpha2.7.11.10.460
1wbmBLLPol protein/0.460
2qd8065Gag-Pol polyprotein3.4.23.160.460
3at3ATKCasein kinase II subunit alpha2.7.11.10.460
3ibqATPPyridoxal kinase/0.460
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.460
3vf9477Tyrosine-protein kinase SYK2.7.10.20.460
4anmWULCasein kinase II subunit alpha2.7.11.10.460
2excJNKMitogen-activated protein kinase 102.7.11.240.459
3i7eDJRGag-Pol polyprotein/0.459
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.459
4deeADPAurora kinase A2.7.11.10.459
1iwiCAMCamphor 5-monooxygenase1.14.15.10.458
2z54AB1Gag-Pol polyprotein3.4.23.160.458
3allFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.458
3hmm855TGF-beta receptor type-12.7.11.300.458
3orkAGSSerine/threonine protein kinase/0.458
3zep1NXTyrosine-protein kinase JAK32.7.10.20.458
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.458
4h3qANPMitogen-activated protein kinase 12.7.11.240.458
4hnc0UTMandelate racemase/0.458
4k6z1Q3Tyrosine-protein kinase JAK1/0.458
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.457
2r5q1UNGag-Pol polyprotein/0.457
3oriAGSSerine/threonine protein kinase/0.457
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.457
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.457
2yxuATPPyridoxal kinase2.7.1.350.456
2z6dFMNPhototropin-22.7.11.10.456
4fkq42KCyclin-dependent kinase 22.7.11.220.456
4ix5ANPUncharacterized protein/0.456
2c5nCK8Cyclin-dependent kinase 22.7.11.220.455
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.455
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.455
2qak1UNGag-Pol polyprotein3.4.23.160.455
2uy0HV1Gag-Pol polyprotein3.4.23.160.455
2uzlC94Cyclin-dependent kinase 22.7.11.220.455
2wqeADPAurora kinase A2.7.11.10.455
3cktYDPGag-Pol polyprotein3.4.23.160.455
3hx4ANPCalmodulin-domain protein kinase 1/0.455
3qn8NI7Gag-Pol polyprotein3.4.23.160.455
3qqhX0ACyclin-dependent kinase 22.7.11.220.455
4i22IREEpidermal growth factor receptor2.7.10.10.455
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.455
4o0uADNAurora kinase A2.7.11.10.455
1hk2T44Serum albumin/0.454
1y91CT9Cyclin-dependent kinase 22.7.11.220.454
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.454
3be9P04Casein kinase II subunit alpha2.7.11.10.454
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.454
3el51UNGag-Pol polyprotein/0.454
3gxlQIGTGF-beta receptor type-12.7.11.300.454
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.454
4bcpT3CCyclin-dependent kinase 22.7.11.220.454
4fkg4CKCyclin-dependent kinase 22.7.11.220.454
1h1q2A6Cyclin-dependent kinase 22.7.11.220.453
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.453
1xl5190Gag-Pol polyprotein3.4.23.160.453
2qnpQN2Gag-Pol polyprotein3.4.23.160.453
3h86AP5Adenylate kinase/0.453
3qihNI7Gag-Pol polyprotein3.4.23.160.453
4c57FEFCyclin-G-associated kinase2.7.11.10.453
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.453
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.453
4tuvCPZCytochrome P450 1191.140.453
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.452
2r64740Cyclin-dependent kinase 22.7.11.220.452
3lfqA28Cyclin-dependent kinase 22.7.11.220.452
4fv7E94Mitogen-activated protein kinase 12.7.11.240.452
4k33ACPFibroblast growth factor receptor 32.7.10.10.452
4oauADP2-5A-dependent ribonuclease3.1.260.452
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.452
1hiiC20Gag-Pol polyprotein/0.451
1i59ANPChemotaxis protein CheA2.7.13.30.451
1jstATPCyclin-dependent kinase 22.7.11.220.451
1rw8580TGF-beta receptor type-12.7.11.300.451
1t88CAMCamphor 5-monooxygenase1.14.15.10.451
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.451
3t8oATPRhodopsin kinase/0.451
3vf7031Gag-Pol polyprotein3.4.23.160.451
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.450
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.450
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.450
2om9AJAPeroxisome proliferator-activated receptor gamma/0.450
3kfs3TLGag-Pol polyprotein/0.450
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.450
1h1s4SPCyclin-dependent kinase 22.7.11.220.449
1m2rMNYCasein kinase II subunit alpha2.7.11.10.449
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.449
2fy4COACholine O-acetyltransferase2.3.1.60.449
2pwrG4GGag-Pol polyprotein3.4.23.160.449
2qnnQN1Gag-Pol polyprotein3.4.23.160.449
2r3wG3GGag-Pol polyprotein3.4.23.160.449
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.449
3friSAH16S rRNA methylase/0.449
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.449
4l4cCAMCamphor 5-monooxygenase1.14.15.10.449
1bdlIM1Gag-Pol polyprotein3.4.23.160.448
1pxpCK8Cyclin-dependent kinase 22.7.11.220.448
2b7aIZATyrosine-protein kinase JAK2/0.448
2wotZZGTGF-beta receptor type-12.7.11.300.448
2z3uCRRCytochrome P450/0.448
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.448
3icsADPCoenzyme A disulfide reductase/0.448
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.448
4mwhATPCasein kinase II subunit alpha2.7.11.10.448
1oguST8Cyclin-dependent kinase 22.7.11.220.447
1om1IQACasein kinase II subunit alpha2.7.11.10.447
1pxoCK7Cyclin-dependent kinase 22.7.11.220.447
1x2hLPALipoate-protein ligase A6.3.1.200.447
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.447
3c4vLIPD-inositol 3-phosphate glycosyltransferase2.4.1.2500.447
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.447
3r374CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.447
1hk5T44Serum albumin/0.446
1phgMYTCamphor 5-monooxygenase1.14.15.10.446
2p33J07Mitogen-activated protein kinase 102.7.11.240.446
2pwcG3GGag-Pol polyprotein3.4.23.160.446
2r43G3GGag-Pol polyprotein3.4.23.160.446
3b895GP16S rRNA methylase/0.446
3rk507ZCyclin-dependent kinase 22.7.11.220.446
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.446
4fkj11KCyclin-dependent kinase 22.7.11.220.446
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.446
4hvi19STyrosine-protein kinase JAK32.7.10.20.446
4l9i8PRRhodopsin kinase/0.446
4qysPLRTryptophan synthase beta chain 24.2.1.200.446
1d4hBEHGag-Pol polyprotein3.4.23.160.445
1py5PY1TGF-beta receptor type-12.7.11.300.445
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.445
2q8sL92Peroxisome proliferator-activated receptor gamma/0.445
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
3cgfJNFMitogen-activated protein kinase 102.7.11.240.445
3s79ASDAromatase1.14.14.140.445
3sp9IL2Peroxisome proliferator-activated receptor delta/0.445
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.445
4bgg844Activin receptor type-12.7.11.300.445
1pyePM1Cyclin-dependent kinase 22.7.11.220.444
1u54ACPActivated CDC42 kinase 1/0.444
1zrzBI1Protein kinase C iota type2.7.11.130.444
2c6tDT5Cyclin-dependent kinase 22.7.11.220.444
2cig1DGDihydrofolate reductase1.5.1.30.444
2pqzG0GGag-Pol polyprotein3.4.23.160.444
2pziAXXSerine/threonine-protein kinase PknG2.7.11.10.444
2q631UNGag-Pol polyprotein3.4.23.160.444
3d1z017Gag-Pol polyprotein3.4.23.160.444
3em6017Gag-Pol polyprotein3.4.23.160.444
3nu9478Gag-Pol polyprotein3.4.23.160.444
3pxkPXKFocal adhesion kinase 12.7.10.20.444
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3qrmNK7Gag-Pol polyprotein3.4.23.160.444
3rm618ZCyclin-dependent kinase 22.7.11.220.444
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.444
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.444
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.444
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.444
1jioDEB6-deoxyerythronolide B hydroxylase/0.443
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.443
2q5kAB1Protease/0.443
2v7a627Tyrosine-protein kinase ABL12.7.10.20.443
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3ezrEZRCyclin-dependent kinase 22.7.11.220.443
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.443
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.443
3owj1ELCasein kinase II subunit alpha2.7.11.10.443
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3qtwX3ACyclin-dependent kinase 22.7.11.220.443
4c4f7CEDual specificity protein kinase TTK2.7.12.10.443
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4lfiGNPCasein kinase II subunit alpha2.7.11.10.443
1b38ATPCyclin-dependent kinase 22.7.11.220.442
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1iziQ50Gag-Pol polyprotein3.4.23.160.442
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
3bxsDRSGag-Pol polyprotein3.4.23.160.442
3eyhIZATyrosine-protein kinase JAK1/0.442
3nieANPMitogen-activated protein kinase/0.442
3rmf20ZCyclin-dependent kinase 22.7.11.220.442
3s1dZIRCytokinin dehydrogenase 11.5.99.120.442
4c58824Cyclin-G-associated kinase2.7.11.10.442
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.442
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.442
4jboWPHAurora kinase A2.7.11.10.442
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
5e92ANPTGF-beta receptor type-22.7.11.300.442
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.441
1hsgMK1Gag-Pol polyprotein/0.441
1rszDIHPurine nucleoside phosphorylase2.4.2.10.441
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
2pyn1UNGag-Pol polyprotein3.4.23.160.441
2q5g1FAPeroxisome proliferator-activated receptor delta/0.441
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
3dogNNNCyclin-dependent kinase 22.7.11.220.441
3eljGS7Mitogen-activated protein kinase 82.7.11.240.441
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.441
3qbfJHGGag-Pol polyprotein3.4.23.160.441
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.441
4zseANPEpidermal growth factor receptor2.7.10.10.441
1s3zCOAAminoglycoside N(6')-acetyltransferase type 1/0.440
1unlRRCCyclin-dependent-like kinase 52.7.11.10.440
1z1hHBBGag-Pol polyprotein3.4.23.160.440
2q641UNGag-Pol polyprotein3.4.23.160.440
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.440
3hyz42CHeat shock protein HSP 90-alpha/0.440
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.440
4dqh017Gag-Pol polyprotein/0.440
4eon1ROCyclin-dependent kinase 22.7.11.220.440
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.440
4oavACP2-5A-dependent ribonuclease3.1.260.440
4zohFADPutative oxidoreductase FAD-binding subunit/0.440