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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1mh1GNPRas-related C3 botulinum toxin substrate 1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1mh1GNPRas-related C3 botulinum toxin substrate 1/1.000
1kmqGNPTransforming protein RhoA/0.551
1cxzGSPTransforming protein RhoA/0.539
3kz1GSPTransforming protein RhoA/0.521
1xtsGTPGTP-binding protein Rheb/0.520
2fe4GDPRas-related protein Rab-6B/0.518
2cl6CAGGTPase HRas/0.517
4xvrGNPGTPase HRas/0.517
1xtrGNPGTP-binding protein Rheb/0.516
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.515
1uadGNPRas-related protein Ral-A/0.512
5hpyGDPTransforming protein RhoA/0.512
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.509
3tgpGNPGTPase HRas/0.506
1g17GNPRas-related protein SEC4/0.502
4lhwGNPRas-related protein Rab-8A/0.502
4js0GNPCell division control protein 42 homolog/0.498
1zc4GNPRas-related protein Ral-A/0.497
3qbtGNPRas-related protein Rab-8A/0.495
4xoiGTPTransforming protein RhoA/0.494
4nyjGNPGTPase HRas/0.493
2gcpGSPRho-related GTP-binding protein RhoC/0.491
3lbnGNPGTPase HRas/0.491
5dhaGNPGTP-binding nuclear protein Ran/0.491
3tsoGNPRas-related protein Rab-25/0.489
2rggGNPGTPase HRas/0.488
3i3sGNPGTPase HRas/0.486
4hdqGNPRas-related protein Rap-1b/0.486
3eg5GNPCell division control protein 42 homolog/0.485
4nyiGNPGTPase HRas/0.485
1e96GTPRas-related C3 botulinum toxin substrate 1/0.484
1s1cGNPTransforming protein RhoA/0.484
3v4fGNPGTPase HRas/0.484
3ddcGNPGTPase HRas/0.482
3rabGNPRas-related protein Rab-3A/0.480
1zc3GNPRas-related protein Ral-A/0.479
3e5hGNPRas-related protein Rab-28/0.479
3oiuGNPGTPase HRas/0.479
4o25GTPGTP-binding protein Rheb/0.479
1a2bGSPTransforming protein RhoA/0.475
4dsuGDPGTPase KRas/0.475
1z0aGDPRas-related protein Rab-2A/0.474
1z2cGNPRho-related GTP-binding protein RhoC/0.474
3nbzGTPGTP-binding nuclear protein Ran/0.474
4o2rGDPGTP-binding protein Rheb/0.474
3a58GNPGTP-binding protein RHO1/0.473
4mitGTPRho-related protein racC/0.472
4qxaGTPRas-related protein Rab-9A/0.472
1m7bGTPRho-related GTP-binding protein RhoE/0.469
1zbdGTPRas-related protein Rab-3A/0.469
3oivGNPGTPase HRas/0.469
5jljGNPGTP-binding nuclear protein Ran/0.469
3oesGNPGTPase RhebL1/0.468
1oixGDPRas-related protein Rab-11A/0.465
1ibrGNPGTP-binding nuclear protein Ran/0.464
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.464
3rs5GNPGTPase HRas/0.464
4xvqGNPGTPase HRas/0.464
3cphGDPRas-related protein SEC4/0.463
3th5GNPRas-related C3 botulinum toxin substrate 1/0.463
1t91GTPRas-related protein Rab-7a/0.462
1lfdGNPGTPase HRas/0.461
2zetGTPRas-related protein Rab-27B/0.461
4rkfGNPRas-related protein Rab-3/0.461
1x1rGDPRas-related protein M-Ras/0.460
1ow3GDPTransforming protein RhoA/0.458
5c46GSPRas-related protein Rab-11A/0.457
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.456
4tq9GDPGTPase KRas/0.455
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.454
3kkoGNPRas-related protein M-Ras/0.454
4a83DXCMajor pollen allergen Bet v 1-A/0.452
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.452
4uj3GNPRas-related protein Rab-11A/0.452
1yzqGNPRas-related protein Rab-6A/0.450
4dltGNPGTPase HRas/0.450
5b2zGNPGTPase HRas/0.450
4wa7GDPGTPase KRas/0.447
3a6pGTPGTP-binding nuclear protein Ran/0.446
4uj5GNPRas-related protein Rab-11A/0.446
2ffqGSPRas-related protein Rab-6B/0.445
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.444
4l8gGDPGTPase KRas/0.444
1k5dGNPGTP-binding nuclear protein Ran/0.443
3kucGDPRas-related protein Rap-1A/0.443
4cymGCPRas-related protein Rab-32/0.443
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.442
4l9sGDPGTPase HRas/0.440
4q03GDPGTPase KRas/0.440