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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1m7bGTPRho-related GTP-binding protein RhoE

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1m7bGTPRho-related GTP-binding protein RhoE/1.000
1gwnGTPRho-related GTP-binding protein RhoE/0.528
2clsGTPRho-related GTP-binding protein Rho6/0.501
1cxzGSPTransforming protein RhoA/0.495
1kmqGNPTransforming protein RhoA/0.482
3oivGNPGTPase HRas/0.477
1zc3GNPRas-related protein Ral-A/0.475
2gcpGSPRho-related GTP-binding protein RhoC/0.469
1s1cGNPTransforming protein RhoA/0.464
3kucGDPRas-related protein Rap-1A/0.464
1xtsGTPGTP-binding protein Rheb/0.461
4kvgGTPRas-related protein Rap-1A/0.460
3kz1GSPTransforming protein RhoA/0.458
1zc4GNPRas-related protein Ral-A/0.453
4mitGTPRho-related protein racC/0.452
1xtrGNPGTP-binding protein Rheb/0.451