sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1lfd	GNP	GTPase HRas

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1lfd	GNP	GTPase HRas	/	1.000
1zc3	GNP	Ras-related protein Ral-A	/	0.511
4xvr	GNP	GTPase HRas	/	0.499
1uad	GNP	Ras-related protein Ral-A	/	0.497
4kvg	GTP	Ras-related protein Rap-1A	/	0.484
1zc4	GNP	Ras-related protein Ral-A	/	0.470
4dxa	GSP	Ras-related protein Rap-1b	/	0.464
4o25	GTP	GTP-binding protein Rheb	/	0.459
2fe4	GDP	Ras-related protein Rab-6B	/	0.458
3oes	GNP	GTPase RhebL1	/	0.454
3tso	GNP	Ras-related protein Rab-25	/	0.443
1zbd	GTP	Ras-related protein Rab-3A	/	0.441
3e5h	GNP	Ras-related protein Rab-28	/	0.441
3tkl	GTP	Ras-related protein Rab-1A	/	0.440