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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1lbm137N-(5'-phosphoribosyl)anthranilate isomerase5.3.1.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1lbm137N-(5'-phosphoribosyl)anthranilate isomerase5.3.1.241.000
3h3qH13Collagen type IV alpha-3-binding protein/0.522
3s87ADPRibonucleoside-diphosphate reductase large chain 11.17.4.10.508
3gonANPPhosphomevalonate kinase/0.507
1m8kNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.500
1foaUD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.497
3h3sH15Collagen type IV alpha-3-binding protein/0.496
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.494
3h3r14HCollagen type IV alpha-3-binding protein/0.491
4z36ON3Lysophosphatidic acid receptor 1/0.491
2ii6C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.490
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.488
2ea2F77Methionine aminopeptidase 2/0.487
2uuoLK3UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.487
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.487
3junAJDPhenazine biosynthesis protein A/B/0.487
2b58COADiamine acetyltransferase 1/0.486
1fkjFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.485
3o5rFK5Peptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.485
1xtsGTPGTP-binding protein Rheb/0.483
1yhjR6CPyridoxal kinase2.7.1.350.483
4drp0MDPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.483
2omeNADC-terminal-binding protein 2/0.482
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.482
4a0rDTBBifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial6.3.3.30.481
2dg3RAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.480
3h3t16HCollagen type IV alpha-3-binding protein/0.480
3ivgFG5Pantothenate synthetase6.3.2.10.480
1e2nRCAThymidine kinase/0.479
1fkd818Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.479
1r58AO5Methionine aminopeptidase 2/0.479
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.479
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.478
1tj0FADBifunctional protein PutA1.5.5.20.477
1tllFMNNitric oxide synthase, brain1.14.13.390.477
2ga2A19Methionine aminopeptidase 2/0.477
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.477
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.477
3otwCOAPhosphopantetheine adenylyltransferase/0.477
1a7xFKAPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.476
1kquBR4Phospholipase A2, membrane associated/0.476
1yw8A75Methionine aminopeptidase 2/0.476
2ea4F79Methionine aminopeptidase 2/0.476
4jhz1KVBeta-glucuronidase3.2.1.310.476
4w5kPLPAspartate aminotransferase, mitochondrial/0.476
1fkfFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.475
1x2hLPALipoate-protein ligase A6.3.1.200.475
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.475
4de50JDPantothenate synthetase6.3.2.10.475
4drn0MCPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.475
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.474
1txtCAAHMG-CoA synthase/0.474
2ewvADPTwitching motility protein PilT/0.474
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.474
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.474
1c9hRAPPeptidyl-prolyl cis-trans isomerase FKBP1B5.2.1.80.473
1j4hSUBPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.473
1rfuADPPyridoxal kinase2.7.1.350.473
2b3vACODiamine acetyltransferase 1/0.473
2j3qTFLAcetylcholinesterase3.1.1.70.473
3ag6PAJPantothenate synthetase/0.473
3njuANNAcidic phospholipase A2 33.1.1.40.473
3opmLUIDipeptidyl peptidase 4/0.473
4drm0MCPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.473
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.473
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.473
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.473
4j0v1H7Beta-secretase 13.4.23.460.473
3vw7VPXProteinase-activated receptor 1/0.473
1xvaSAMGlycine N-methyltransferase2.1.1.200.472
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.472
2iu0203Bifunctional purine biosynthesis protein PURH2.1.2.30.472
2rlcCHDCholoylglycine hydrolase3.5.1.240.472
2zcvNDPQuinone oxidoreductase 21.6.5.20.472
3t7qRB4Endothiapepsin3.4.23.220.472
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.472
4hn1TYDdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.472
1dgmADNAdenosine kinase2.7.1.200.471
1gaxVAAValine--tRNA ligase6.1.1.90.471
1r5gAO1Methionine aminopeptidase 2/0.471
3fhxPLPPyridoxal kinase2.7.1.350.471
3iu9T07Methionine aminopeptidase 2/0.471
4mo4ACPAnhydro-N-acetylmuramic acid kinase/0.471
4zlaBESCytosol aminopeptidase3.4.11.10.471
1fkbRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.470
1lkeDOGBilin-binding protein/0.470
1o9bNAIQuinate/shikimate dehydrogenase/0.470
1vi2NADQuinate/shikimate dehydrogenase/0.470
2xuoTZ4Acetylcholinesterase3.1.1.70.470
3c35KAIGlutamate receptor ionotropic, kainate 1/0.470
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
4jicFMNGTN Reductase/0.470
1w6rGNTAcetylcholinesterase3.1.1.70.469
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.469
3pdqKC6Lysine-specific demethylase 4A1.14.110.469
1j1zATPArgininosuccinate synthase/0.468
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.468
1q6iFK5FKBP-type peptidyl-prolyl cis-trans isomerase FkpA5.2.1.80.468
2ab8MTPAdenosine kinase2.7.1.200.468
2aj8SC3Dipeptidyl peptidase 4/0.468
2hfuMEVMevalonate kinase/0.468
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.468
3g0dXIHDipeptidyl peptidase 4/0.468
3gqvNAPEnoyl reductase LovC10.468
3junAKDPhenazine biosynthesis protein A/B/0.468
1odcA8BAcetylcholinesterase3.1.1.70.467
1r5hAO2Methionine aminopeptidase 2/0.467
1snfUMPDeoxyuridine 5'-triphosphate nucleotidohydrolase3.6.1.230.467
1tkaN3TTransketolase 12.2.1.10.467
2fxuBIDActin, alpha skeletal muscle/0.467
2iiqC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.467
2q9cGNPSignal recognition particle receptor FtsY/0.467
2uupLK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.467
3t64DU3Deoxyuridine 5'-triphosphate nucleotidohydrolase/0.467
4araC56Acetylcholinesterase3.1.1.70.467
4fxy0W2Neurolysin, mitochondrial3.4.24.160.467
4qxaGTPRas-related protein Rab-9A/0.467
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.466
1qpl587Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.466
1tilATPAnti-sigma F factor/0.466
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.466
2y67N21UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.466
3fp0FP015-O-acetyltransferase/0.466
3p80P80Pentaerythritol tetranitrate reductase/0.466
3q43D66M1 family aminopeptidase3.4.110.466
4dptAGSMevalonate diphosphate decarboxylase/0.466
4h2dFMNNADPH-dependent diflavin oxidoreductase 1/0.466
4m0f1YKAcetylcholinesterase3.1.1.70.466
1nvtNAPShikimate dehydrogenase (NADP(+))/0.465
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.465
2g1n1IGRenin3.4.23.150.465
2ha6SCKAcetylcholinesterase3.1.1.70.465
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.465
2z4sADPChromosomal replication initiator protein DnaA/0.465
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
4klaCHDFerrochelatase, mitochondrial4.99.1.10.465
4lngJANCaaX farnesyltransferase beta subunit Ram1/0.465
4rp8ASCAscorbate-specific PTS system EIIC component/0.465
1qu3MRCIsoleucine--tRNA ligase6.1.1.50.464
1zdfUPGGlycogenin-12.4.1.1860.464
1zdgUPGGlycogenin-12.4.1.1860.464
2bsxNOSPurine nucleoside phosphorylase/0.464
2pakTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.464
3fr5I4AFatty acid-binding protein, adipocyte/0.464
3ixp834Ecdysone receptor/0.464
3opxU5PSuppressor of disruption of TFIIS/0.464
1cnwEG1Carbonic anhydrase 24.2.1.10.463
1i5eU5PUracil phosphoribosyltransferase/0.463
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.463
2x9dITCTetracycline repressor protein class D/0.463
2zshGA3Gibberellin receptor GID1A30.463
4c02TAKActivin receptor type-12.7.11.300.463
4isuIKMGlutamate receptor 2/0.463
1dliUDXUDP-glucose 6-dehydrogenase/0.462
2d3aADPGlutamine synthetase root isozyme 36.3.1.20.462
2oazI96Methionine aminopeptidase 2/0.462
3zhyFM61-deoxy-D-xylulose 5-phosphate reductoisomerase/0.462
4q0kGA3Phytohormone-binding protein/0.462
1kw6BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.461
1kw9BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.461
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.461
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.461
2a9y26AAdenosine kinase2.7.1.200.461
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.461
2qbuSAHPrecorrin-2 methyltransferase/0.461
2xpc051UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.461
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.461
4dh0MR8Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.461
4dnaFADProbable glutathione reductase/0.461
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.461
4qt3RAPPeptidylprolyl isomerase/0.461
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.461
5c1d12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.461
1hfqMOTDihydrofolate reductase1.5.1.30.460
1v8lAPRADP-ribose pyrophosphatase/0.460
2vyqFADFerredoxin--NADP reductase1.18.1.20.460
3anlSYC1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.460
3apwDP0Alpha-1-acid glycoprotein 2/0.460
3b6pTMPThree-prime repair exonuclease 13.1.11.20.460
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.460
4dz2FK5Peptidyl-prolyl cis-trans isomerase/0.460
4opgFDAConserved Archaeal protein/0.460
5bnw12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.460
1qtiGNTAcetylcholinesterase3.1.1.70.459
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.459
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
2p83MR0Beta-secretase 13.4.23.460.459
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.459
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.459
3c8aARG_ARG_GLY_LEU_NH2Botulinum neurotoxin type A3.4.24.690.459
3g0gRUMDipeptidyl peptidase 4/0.459
3lzs017Gag-Pol polyprotein3.4.23.160.459
4a81DXCMajor pollen allergen Bet v 1-A/0.459
1fyfSSAThreonine--tRNA ligase6.1.1.30.458
1h74AGSHomoserine kinase2.7.1.390.458
2cy0NAPShikimate dehydrogenase (NADP(+))/0.458
2pk3GDDGDP-6-deoxy-D-mannose reductase/0.458
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3gncQQQGlutaryl-CoA dehydrogenase/0.458
3ll9ADPIsopentenyl phosphate kinase/0.458
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4jfi1KTPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.458
5a03NDPGlucose-fructose oxidoreductase/0.458
1daaPLPD-alanine aminotransferase2.6.1.210.457
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.457
1szgFNSCytochrome b2, mitochondrial1.1.2.30.457
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.457
3pzcGAPAmino acid--[acyl-carrier-protein] ligase 16.2.1.n20.457
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
1eveE20Acetylcholinesterase3.1.1.70.456
1fklRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.456
1j0xNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.456
1jzsMRCIsoleucine--tRNA ligase6.1.1.50.456
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.456
1rdwLARActin, alpha skeletal muscle/0.456
1vhzAPRADP compounds hydrolase NudE3.6.10.456
1zbdGTPRas-related protein Rab-3A/0.456
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2cv2GSUGlutamate--tRNA ligase6.1.1.170.456
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.456
2webPP4Penicillopepsin-13.4.23.200.456
3oikWZBCarbonic anhydrase 24.2.1.10.456
3rykTYDdTDP-4-dehydrorhamnose 3,5-epimerase/0.456
3sl2ATPSensor histidine kinase WalK/0.456
4b45GSPTubulin-like protein CetZ2/0.456
4b7754MBeta-secretase 13.4.23.460.456
4bfzZVZPantothenate kinase2.7.1.330.456
4fsl0VBBeta-secretase 13.4.23.460.456
4xd1T3QQdtf/0.456
1rzuADPGlycogen synthase 12.4.1.210.455
2qc8ADPGlutamine synthetase6.3.1.20.455
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.455
2w9hTOPDihydrofolate reductase1.5.1.30.455
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.455
2y60M8FIsopenicillin N synthase1.21.3.10.455
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.455
4du82P0Mevalonate diphosphate decarboxylase/0.455
4gn8ASORegucalcin3.1.1.170.455
4imgNGFN-acetylneuraminate lyase/0.455
4lzwTHMUridine phosphorylase/0.455
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.455
1i59ANPChemotaxis protein CheA2.7.13.30.454
1icpFMN12-oxophytodienoate reductase 11.3.1.420.454
2p5uNADUDP-glucose 4-epimerase/0.454
3n0hTOPDihydrofolate reductase1.5.1.30.454
3phiNDPShikimate dehydrogenase (NADP(+))/0.454
4ddyDN6Beta-lactamase/0.454
4e2wJHZMethyltransferase/0.454
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.454
1pydTDPPyruvate decarboxylase isozyme 1/0.453
1xnjADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.453
2fkeFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.453
2whqHI6Acetylcholinesterase3.1.1.70.453
2x8hFADThioredoxin glutathione reductase/0.453
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.453
2ylzFADPhenylacetone monooxygenase1.14.13.920.453
3djjFADGlutathione reductase, mitochondrial1.8.1.70.453
3imeBZ2Pantothenate synthetase6.3.2.10.453
3iocA5DPantothenate synthetase6.3.2.10.453
3kjgADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.453
3lnc5GPGuanylate kinase/0.453
3uxvGUNNADPH-dependent 7-cyano-7-deazaguanine reductase/0.453
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.453
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
4hxyNDPPlm1/0.453
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase/0.452
1g54FFBCarbonic anhydrase 24.2.1.10.452
1q19SSCCarbapenam-3-carboxylate synthase6.3.3.60.452
1rz0FADPhenol 2-hydroxylase component B/0.452
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.452
2iyfERYOleandomycin glycosyltransferase2.4.10.452
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3eksCY9Actin-5C/0.452
3i0aDBHNeutrophil gelatinase-associated lipocalin/0.452
3iktNADRedox-sensing transcriptional repressor Rex/0.452
3k8q22APurine nucleoside phosphorylase2.4.2.10.452
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.452
3pchCHBProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.452
3v0p4GWHisto-blood group ABO system transferase/0.452
3w77FMNFMN-dependent NADH-azoreductase/0.452
4jdcNADProbable pyrroline-5-carboxylate dehydrogenase RocA/0.452
4oztP1AEcdysone receptor, putative/0.452
1drfFOLDihydrofolate reductase1.5.1.30.451
1ja0NAPNADPH--cytochrome P450 reductase/0.451
1kvkATPMevalonate kinase2.7.1.360.451
1n2jPAFPantothenate synthetase6.3.2.10.451
1od10QSEndothiapepsin3.4.23.220.451
1psa0ZLPepsin A3.4.23.10.451
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
2c20NADUDP-glucose 4-epimerase/0.451
2cjfRP43-dehydroquinate dehydratase4.2.1.100.451
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.451
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.451
2jfhLK1UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.451
2ohvNHLGlutamate racemase/0.451
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.451
2ym2FADPhenylacetone monooxygenase1.14.13.920.451
3bgxTMPThymidylate synthase/0.451
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.451
3mytEQUSteroid Delta-isomerase5.3.3.10.451
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.451
3rvhHQ2Lysine-specific demethylase 4A1.14.110.451
4a802ANMajor pollen allergen Bet v 1-A/0.451
4a87NARMajor pollen allergen Bet v 1-A/0.451
4bfvZVVPantothenate kinase2.7.1.330.451
4g8jTHMUridine phosphorylase/0.451
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.451
1dp2LPBThiosulfate sulfurtransferase/0.450
1h73ANPHomoserine kinase2.7.1.390.450
1hbvGANGag-Pol polyprotein/0.450
1stdBFSScytalone dehydratase4.2.1.940.450
1xtrGNPGTP-binding protein Rheb/0.450
1yw7A41Methionine aminopeptidase 2/0.450
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.450
2briANPUridylate kinase2.7.4.220.450
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.450
2gr1FADFerredoxin reductase/0.450
2powI7CCarbonic anhydrase 24.2.1.10.450
2wqpWQPPolysialic acid capsule biosynthesis protein SiaC/0.450
3e6eDCSAlanine racemase/0.450
3fsjD7KBenzoylformate decarboxylase4.1.1.70.450
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.450
3jpuTY4Transcriptional activator protein LasR/0.450
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.450
3vswR31Renin3.4.23.150.450
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.450
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.450
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.450
1r2jFADFkbI/0.449
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1yzqGNPRas-related protein Rab-6A/0.449
2c9bPUG6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2dg4RAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.449
2dxdANPNucleoside diphosphate kinase2.7.4.60.449
2ffqGSPRas-related protein Rab-6B/0.449
2fznFADBifunctional protein PutA1.5.5.20.449
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.449
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.449
2rqfJH3Hemolymph juvenile hormone binding protein/0.449
2stdCRPScytalone dehydratase4.2.1.940.449
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.449
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.449
3fr28CAFatty acid-binding protein, adipocyte/0.449
3rbaCODPhosphopantetheine adenylyltransferase/0.449
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.449
4kc1WS1Histo-blood group ABO system transferase/0.449
4y9qC2EUncharacterized protein/0.449
4yp12BAStimulator of interferon genes protein/0.449
1bkfFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.448
1ivsVAAValine--tRNA ligase6.1.1.90.448
1jdzFMBPurine nucleoside phosphorylase/0.448
1n3sGTPGTP cyclohydrolase 13.5.4.160.448
1npdNADQuinate/shikimate dehydrogenase/0.448
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.448
2cftPLPPyridoxal phosphate phosphatase/0.448
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.448
2gqwFADFerredoxin reductase/0.448
2gv8NDPThiol-specific monooxygenase1.14.130.448
2vkeTACTetracycline repressor protein class D/0.448
2yphQQY2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.448
3b1dPLSBetaC-S lyase/0.448
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.448
3ibqATPPyridoxal kinase/0.448
3pftFMNFlavin reductase/0.448
3t4eNADQuinate/shikimate dehydrogenase/0.448
3uayADNPurine nucleoside phosphorylase DeoD-type/0.448
3wycNAPMeso-diaminopimelate D-dehydrogenase1.4.1.160.448
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4opiFDAConserved Archaeal protein/0.448
4xr9NADCalS8/0.448
4y45F91Endothiapepsin3.4.23.220.448
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.448
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.447
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.447
1g9bBABBotulinum neurotoxin type B3.4.24.690.447
1gilGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.447
1if8SBSCarbonic anhydrase 24.2.1.10.447
1ur5NADMalate dehydrogenase/0.447
1w34FADFerredoxin--NADP reductase1.18.1.20.447
1w6hTITPlasmepsin-23.4.23.390.447
1xddAAYIntegrin alpha-L/0.447
2cdaNAPGlucose 1-dehydrogenase/0.447
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.447
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.447
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.447
2q46NAPUncharacterized protein At5g02240/0.447
2y882ERPhosphoribosyl isomerase A5.3.1.160.447
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.447
3cb2GDPTubulin gamma-1 chain/0.447
3imgBZ3Pantothenate synthetase6.3.2.10.447
3jusBCDLanosterol 14-alpha demethylase1.14.13.700.447
3pmuF7LEndothiapepsin3.4.23.220.447
3py4TYLLactoperoxidase1.11.1.70.447
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.447
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.447
3wt0ATPCell division protein FtsA/0.447
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4jzr4JREgl nine homolog 1/0.447
4lh71X8DNA ligase/0.447
4req5ADMethylmalonyl-CoA mutase large subunit5.4.99.20.447
4rrrA3TThreonine--tRNA ligase6.1.1.30.447
5iqiGNPBifunctional AAC/APH2.3.10.447
1dmyAZMCarbonic anhydrase 5A, mitochondrial4.2.1.10.446
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.446
1h22E10Acetylcholinesterase3.1.1.70.446
1h60STRPentaerythritol tetranitrate reductase/0.446
1jdtMTAPurine nucleoside phosphorylase/0.446
1kh3ANPArgininosuccinate synthase/0.446
1n2gAPCPantothenate synthetase6.3.2.10.446
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
1ra8FOLDihydrofolate reductase1.5.1.30.446
1ri4SAMmRNA cap guanine-N7 methyltransferase2.1.1.560.446
1zji2PG2-dehydro-3-deoxyphosphooctonate aldolase2.5.1.550.446
2c29NAPDihydroflavonol 4-reductase/0.446
2dhfDZFDihydrofolate reductase1.5.1.30.446
2ejzSAHDiphthine synthase/0.446
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.446
2vqbFADPutative flavin-containing monooxygenase/0.446
2w6cBM4Acetylcholinesterase3.1.1.70.446
2x06NADL-sulfolactate dehydrogenase/0.446
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.446
3dzkNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.446
4a6rTA8Probable aminotransferase/0.446
4acxS8ZBeta-secretase 13.4.23.460.446
4fhbFOLDihydrofolate reductase1.5.1.30.446
4i101BSBeta-secretase 13.4.23.460.446
4kc4WS3Histo-blood group ABO system transferase/0.446
4r81FMNPredicted NADH dehydrogenase/0.446
4xczFONQdtf/0.446
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.446
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.446
1gpuTHDTransketolase 12.2.1.10.445
1iayAVG1-aminocyclopropane-1-carboxylate synthase 24.4.1.140.445
1k5dGNPGTP-binding nuclear protein Ran/0.445
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.445
1ot3THMDeoxynucleoside kinase/0.445
1qrpHH0Pepsin A-43.4.23.10.445
1tqf32PBeta-secretase 13.4.23.460.445
1vg8GNPRas-related protein Rab-7a/0.445
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.445
2getCOKPantothenate kinase2.7.1.330.445
2uxoTACHTH-type transcriptional regulator TtgR/0.445
2v16C47Renin3.4.23.150.445
2yj4ATPCopper-transporting ATPase/0.445
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.445
3dbuD8WCarbonic anhydrase 24.2.1.10.445
3ivcFG4Pantothenate synthetase6.3.2.10.445
3oafOAGDihydrofolate reductase1.5.1.30.445
3qvrFADGlucose oxidase1.1.3.40.445
3t7vSAM3-methylornithine synthase/0.445
3toh079Gag-Pol polyprotein2.7.7.490.445
3vdqNAD3-hydroxybutyrate dehydrogenase/0.445
3zksWZVBeta-secretase 23.4.23.450.445
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.445
4da0GNGPurine nucleoside phosphorylase DeoD-type2.4.2.10.445
4f5yC2EStimulator of interferon genes protein/0.445
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.445
4ikzAFSDi-tripeptide ABC transporter (Permease)/0.445
4jtqNAPAldo-keto reductase family 1 member C2/0.445
4la1FADThioredoxin glutathione reductase/0.445
4m83ERYOleandomycin glycosyltransferase2.4.10.445
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.445
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.445
4uugPXGBranched-chain amino acid aminotransferase, putative/0.445
4yj2GTPTubulin alpha-1B chain/0.445
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.445
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.444
1ao05GPAmidophosphoribosyltransferase/0.444
1b2lNDCAlcohol dehydrogenase1.1.1.10.444
1fwkADPHomoserine kinase2.7.1.390.444
1korANPArgininosuccinate synthase/0.444
1pwuGM6Lethal factor3.4.24.830.444
1svmATPLarge T antigen3.6.40.444
1t3zCAOFormyl-CoA:oxalate CoA-transferase/0.444
1towCRZFatty acid-binding protein, adipocyte/0.444
1uxyEPUUDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.444
1vikBAYGag-Pol polyprotein/0.444
1x1cSAHC-20 methyltransferase/0.444
1z6tADPApoptotic protease-activating factor 1/0.444
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2dvoITTdITP/XTP pyrophosphatase3.6.1.190.444
2ev9NAPShikimate dehydrogenase (NADP(+))/0.444
2i7pACOPantothenate kinase 32.7.1.330.444
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.444
2zjfBSUEpoxide hydrolase B/0.444
3atyFMNProstaglandin F2a synthase/0.444
3ccc7ACDipeptidyl peptidase 4/0.444
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3g0cRUFDipeptidyl peptidase 4/0.444
3lm9ADPPutative fructokinase2.7.1.40.444
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.444
3phcIM5Purine nucleoside phosphorylase/0.444
3qw8CYS_ARG_GLY_CYS_NH2Botulinum neurotoxin type A3.4.24.690.444
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.444
3wagTYDGlycosyltransferase/0.444
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.444
4i13FOLDihydrofolate reductase1.5.1.30.444
4layI63Peptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.444
4m4922YL-lactate dehydrogenase A chain1.1.1.270.444
4n4v2GYTankyrase-12.4.2.300.444
4tmbFMNOld yellow enzyme/0.444
4tyqAP5Adenylate kinase/0.444
4umyNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
5hg0SAMPantothenate synthetase/0.444
1e66HUXAcetylcholinesterase3.1.1.70.443
1gvrTNLPentaerythritol tetranitrate reductase/0.443
1jmfUMPThymidylate synthase/0.443
1juvNDPDihydrofolate reductase1.5.1.30.443
1m76CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.443
1q1rFADPutidaredoxin reductase1.18.1.50.443
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.443
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.443
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.443
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/0.443
2v34CTN4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.443
3c36KAIGlutamate receptor ionotropic, kainate 1/0.443
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.443
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.443
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3hl0NADMaleylacetate reductase/0.443
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.443
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3nsh957Beta-secretase 13.4.23.460.443
3pi0F91Endothiapepsin3.4.23.220.443
3tnlNADShikimate dehydrogenase (NADP(+))/0.443
3ua808WGlutamate receptor 2/0.443
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3v0o4GWHisto-blood group ABO system transferase/0.443
3wv9FEGHmd co-occurring protein HcgE/0.443
4a862ANMajor pollen allergen Bet v 1-A/0.443
4dlcUMPDeoxyuridine triphosphatase, putative/0.443
4ey7E20Acetylcholinesterase3.1.1.70.443
4f9gC2EStimulator of interferon genes protein/0.443
4frkDWDBeta-secretase 13.4.23.460.443
4gcmNAPThioredoxin reductase1.8.1.90.443
4i0i957Beta-secretase 13.4.23.460.443
4j0p1H8Beta-secretase 13.4.23.460.443
4l7vSAHProtein-L-isoaspartate O-methyltransferase/0.443
4m6jNDPDihydrofolate reductase1.5.1.30.443
3uonQNBMuscarinic acetylcholine receptor M2/0.443
1cqp803Integrin alpha-L/0.442
1culFOKAdenylate cyclase type 2/0.442
1culFOKAdenylate cyclase type 5/0.442
1dx6GNTAcetylcholinesterase3.1.1.70.442
1e2kTMCThymidine kinase/0.442
1g9aBABBotulinum neurotoxin type B3.4.24.690.442
1je1GMPPurine nucleoside phosphorylase/0.442
1pr1FMBPurine nucleoside phosphorylase DeoD-type/0.442
1touB1VFatty acid-binding protein, adipocyte/0.442
2an9GDPGuanylate kinase2.7.4.80.442
2bf7HBIPteridine reductase 11.5.1.330.442
2d32ANPGlutamate--cysteine ligase6.3.2.20.442
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.442
2pncCLUPrimary amine oxidase, liver isozyme/0.442
2v74SAHHistone-arginine methyltransferase CARM1/0.442
2xuhTZ4Acetylcholinesterase3.1.1.70.442
2zr9DTPProtein RecA/0.442
3b4p3B4Phenazine biosynthesis protein A/B/0.442
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.442
3dd0EZLCarbonic anhydrase 24.2.1.10.442
3fgdBYAThermolysin3.4.24.270.442
3g0bT22Dipeptidyl peptidase 4/0.442
3gc52MQQueuine tRNA-ribosyltransferase2.4.2.290.442
3muoZPRProlyl endopeptidase/0.442
3nt2NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.442
3uptTPPTransketolase/0.442
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
3zv7NHGAcetylcholinesterase3.1.1.70.442
4c1eMCOBeta-lactamase class B VIM-2/0.442
4er6AW2Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.442
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.442
4gddNAIUDP-galactopyranose mutase/0.442
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4ycpFMNtRNA-dihydrouridine(16) synthase/0.442
5c8d5ADProbable transcriptional regulator/0.442
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.441
1il0NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
1kiaSAMGlycine N-methyltransferase2.1.1.200.441
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.441
1n2eAPCPantothenate synthetase6.3.2.10.441
1t7o152Carnitine O-acetyltransferase2.3.1.70.441
1u65CP0Acetylcholinesterase3.1.1.70.441
1uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.441
2anb5GPGuanylate kinase2.7.4.80.441
2db3ANPATP-dependent RNA helicase vasa, isoform A3.6.4.130.441
2djlFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.441
2eu3FF3Carbonic anhydrase 24.2.1.10.441
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
2ztuNADD(-)-3-hydroxybutyrate dehydrogenase/0.441
3ck7ACXStarch-binding protein SusD/0.441
3em3478Gag-Pol polyprotein3.4.23.160.441
3kkzSAMUncharacterized protein/0.441
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.441
3rk1ATPN-type ATP pyrophosphatase superfamily/0.441
4a6nFADTetX family tetracycline inactivation enzyme/0.441
4d03FADPhenylacetone monooxygenase1.14.13.920.441
4f3xNADPutative aldehyde dehydrogenase/0.441
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.441
4yagNAIC alpha-dehydrogenase/0.441
5a1tNAIL-lactate dehydrogenase/0.441
5e7oMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.441
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.441
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.440
1ay0TPPTransketolase 12.2.1.10.440
1bl4AP1Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1gveNAPAflatoxin B1 aldehyde reductase member 310.440
1kwqSG1Carbonic anhydrase 24.2.1.10.440
1n77ATPGlutamate--tRNA ligase6.1.1.170.440
1oklMNSCarbonic anhydrase 24.2.1.10.440
1pd9CO4Dihydrofolate reductase1.5.1.30.440
1vbiNADMalate/L-lactate dehydrogenase family protein/0.440
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2ex1C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.440
2fhnBNIAvidin-related protein 4/5/0.440
2olrATPPhosphoenolpyruvate carboxykinase (ATP)/0.440
2pdtFADVivid PAS protein VVD/0.440
2v59LZKBiotin carboxylase6.3.4.140.440
2xupTZ5Acetylcholinesterase3.1.1.70.440
3d3xARG_ILE_MET_GLU_NH2Type E botulinum toxin/0.440
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.440
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.440
3fktSIIBeta-secretase 13.4.23.460.440
3h2sNDPPutative NADH-flavin reductase/0.440
3hk1B64Fatty acid-binding protein, adipocyte/0.440
3juqAJDPhenazine biosynthesis protein A/B/0.440
3m96E38Carbonic anhydrase 24.2.1.10.440
3ohh3HHBeta-secretase 13.4.23.460.440
3orfNADDihydropteridine reductase1.5.1.340.440
3sfh1DIHistone deacetylase 83.5.1.980.440
4afgQMRAchbp/0.440
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.440
4ef4C2EStimulator of interferon genes protein/0.440
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.440
4rpgFADUDP-galactopyranose mutase5.4.99.90.440
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.440
4xczT3QQdtf/0.440
4yau2AMNADPH--cytochrome P450 reductase/0.440
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.440