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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kv9PQQQuinohemoprotein alcohol dehydrogenase ADH IIB

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1kv9PQQQuinohemoprotein alcohol dehydrogenase ADH IIB/1.000
1mueCDDProthrombin3.4.21.50.462
1sb1165Prothrombin3.4.21.50.461
1c1uBAIProthrombin3.4.21.50.459
1zrb062Prothrombin3.4.21.50.457
1d6w00RProthrombin3.4.21.50.455
3kytHC2Nuclear receptor ROR-gamma/0.454
2anb5GPGuanylate kinase2.7.4.80.453
3e5hGNPRas-related protein Rab-28/0.453
2r2mI50Prothrombin3.4.21.50.448
1yplRA8Prothrombin3.4.21.50.445
2ej2PPEBranched-chain amino acid aminotransferase (IlvE)/0.445
1zgi382Prothrombin3.4.21.50.444
2zf051UProthrombin3.4.21.50.443
3nh8DC2N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)3.5.1.1140.443
1k21IGNProthrombin3.4.21.50.442
1ypkCCRProthrombin3.4.21.50.442
3eq02TSProthrombin3.4.21.50.442
3wtkTH4Acetylcholine-binding protein/0.442
1umaIN2Prothrombin3.4.21.50.441
1ypmRA4Prothrombin3.4.21.50.441
1yzqGNPRas-related protein Rab-6A/0.441
1zgv501Prothrombin3.4.21.50.441
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4yklGMPAprataxin-like protein30.441
2zhw12UProthrombin3.4.21.50.440
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.440