sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1kph | SAH | Cyclopropane mycolic acid synthase 1 | 2.1.1.79 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1kph | SAH | Cyclopropane mycolic acid synthase 1 | 2.1.1.79 | 1.000 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.568 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.558 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.553 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.532 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.501 | |
| 1nv8 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.493 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.491 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.489 | |
| 4nec | SAH | Putative SAM-dependent methyltransferase | / | 0.488 | |
| 2a14 | SAH | Indolethylamine N-methyltransferase | 2.1.1.49 | 0.487 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.486 | |
| 4r6x | SAH | Phosphoethanolamine N-methyltransferase | / | 0.486 | |
| 2zfu | SAH | Ribosomal RNA-processing protein 8 | / | 0.484 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.482 | |
| 3n6u | TSU | HTH-type transcriptional regulator TsaR | / | 0.482 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.482 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.481 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.481 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.481 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.481 | |
| 4nyi | GNP | GTPase HRas | / | 0.480 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.479 | |
| 3ou6 | SAM | SAM-dependent methyltransferase | / | 0.479 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.478 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.478 | |
| 1wy7 | SAH | Uncharacterized protein | / | 0.478 | |
| 2bzg | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.478 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.477 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3up0 | D7S | aceDAF-12 | / | 0.476 | |
| 1yf3 | SAH | DNA adenine methylase | / | 0.475 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 3e23 | SAM | Uncharacterized protein | / | 0.475 | |
| 1g60 | SAM | Modification methylase MboII | 2.1.1.72 | 0.474 | |
| 3eks | CY9 | Actin-5C | / | 0.474 | |
| 3kpj | SAH | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.474 | |
| 4f86 | SFG | Geranyl diphosphate 2-C-methyltransferase | 2.1.1.255 | 0.474 | |
| 1boo | SAH | Modification methylase PvuII | 2.1.1.113 | 0.471 | |
| 3vc1 | SAH | Geranyl diphosphate 2-C-methyltransferase | 2.1.1.255 | 0.471 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.471 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2eg5 | SAH | 7-methylxanthosine synthase 1 | / | 0.470 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.470 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3lbn | GNP | GTPase HRas | / | 0.469 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.468 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.468 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.468 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.468 | |
| 4fgz | SAH | Phosphoethanolamine N-methyltransferase | / | 0.468 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.467 | |
| 1vq1 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.467 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.467 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.467 | |
| 3eku | CY9 | Actin-5C | / | 0.466 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.466 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 3ou7 | SAM | SAM-dependent methyltransferase | / | 0.465 | |
| 3rs5 | GNP | GTPase HRas | / | 0.465 | |
| 3t7x | 4SH | Endothiapepsin | 3.4.23.22 | 0.465 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.465 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.465 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.464 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.464 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1s1c | GNP | Transforming protein RhoA | / | 0.463 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.463 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.462 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2r8p | T6F | Transketolase 1 | / | 0.462 | |
| 3gya | COA | GCN5-related N-acetyltransferase | / | 0.462 | |
| 3oiv | GNP | GTPase HRas | / | 0.462 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.462 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 5dp2 | NAP | CurF | / | 0.461 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3ely | SAH | Methyltransferase | / | 0.460 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.460 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.460 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.459 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.459 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.459 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.459 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.459 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.459 | |
| 5bw4 | SAM | Uncharacterized protein | / | 0.459 | |
| 1bc5 | SAH | Chemotaxis protein methyltransferase | 2.1.1.80 | 0.458 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.458 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.458 | |
| 3v4f | GNP | GTPase HRas | / | 0.458 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.458 | |
| 4c67 | L5S | Bromodomain-containing protein 4 | / | 0.458 | |
| 4kxj | P34 | Nucleoprotein | / | 0.458 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 4nyj | GNP | GTPase HRas | / | 0.458 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.457 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.457 | |
| 3s1s | SAH | Restriction endonuclease BpuSI | / | 0.457 | |
| 3vc2 | SAH | Geranyl diphosphate 2-C-methyltransferase | 2.1.1.255 | 0.457 | |
| 4mit | GTP | Rho-related protein racC | / | 0.457 | |
| 4rto | SFG | DNA adenine methylase | 2.1.1.72 | 0.457 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.457 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.456 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2e8s | SAH | Diphthine synthase | / | 0.456 | |
| 2hvd | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.456 | |
| 2ob0 | ACO | N-alpha-acetyltransferase 50 | / | 0.456 | |
| 2r8o | T5X | Transketolase 1 | / | 0.456 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.456 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.456 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.456 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.456 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.456 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1fkw | PUR | Adenosine deaminase | 3.5.4.4 | 0.455 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.455 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.455 | |
| 3pbz | F02 | Endothiapepsin | 3.4.23.22 | 0.455 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.455 | |
| 4bix | ADP | Sensor histidine kinase CpxA | / | 0.455 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.455 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.455 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3mtw | M3R | Xaa-Pro dipeptidase, putative | / | 0.454 | |
| 4yd7 | F5N | Endothiapepsin | 3.4.23.22 | 0.454 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.453 | |
| 1sg9 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.453 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2wvl | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.453 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.453 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.453 | |
| 3rs7 | GNP | GTPase HRas | / | 0.453 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.452 | |
| 2ih2 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.452 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.452 | |
| 3uj8 | SFG | Phosphoethanolamine N-methyltransferase | / | 0.452 | |
| 4b4d | FAD | Ferredoxin-NADP reductase | / | 0.452 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.451 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.451 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.450 | |
| 1r00 | SAH | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.450 | |
| 2f8l | SAM | Lmo1582 protein | / | 0.450 | |
| 2okc | SAM | Probable type I restriction enzyme BthVORF4518P M protein | 2.1.1.72 | 0.450 | |
| 2p41 | SAH | Genome polyprotein | / | 0.450 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.450 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.450 | |
| 4fw0 | 5KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.450 | |
| 5c80 | URI | Uridine phosphorylase | / | 0.450 | |
| 1qip | GNB | Lactoylglutathione lyase | 4.4.1.5 | 0.449 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.449 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.449 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.449 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.449 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.449 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.449 | |
| 4lde | P0G | Beta-2 adrenergic receptor | / | 0.449 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.448 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 2ahv | COA | Acetate CoA-transferase YdiF | 2.8.3.8 | 0.448 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 3e6e | DCS | Alanine racemase | / | 0.448 | |
| 3ksl | SZH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.448 | |
| 3tnf | GNP | Ras-related protein Rab-8A | / | 0.448 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.448 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.448 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.448 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.447 | |
| 1wbp | ADP | SRSF protein kinase 1 | 2.7.11.1 | 0.447 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.447 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3pll | F06 | Endothiapepsin | 3.4.23.22 | 0.447 | |
| 3pt9 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.447 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.447 | |
| 4mwz | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.447 | |
| 4tta | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.447 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.446 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.446 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.446 | |
| 3p9k | SAH | Caffeic acid O-methyltransferase | / | 0.446 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.446 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.446 | |
| 4kvg | GTP | Ras-related protein Rap-1A | / | 0.446 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.446 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.446 | |
| 4rph | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 5a2y | UTP | Mitochondrial poly(A) polymerase | / | 0.446 | |
| 5epe | SAH | Uncharacterized protein | / | 0.446 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1zdw | FLV | Prenyltransferase | / | 0.445 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.445 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.445 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 4blw | SAH | Ribosomal RNA large subunit methyltransferase J | / | 0.445 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.445 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.445 | |
| 5i39 | FAD | L-amino acid deaminase | / | 0.445 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.444 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.444 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.444 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.444 | |
| 2b8t | THM | Thymidine kinase | / | 0.444 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.444 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.444 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.444 | |
| 4jkt | 04A | Glutaminase kidney isoform, mitochondrial | 3.5.1.2 | 0.444 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 4y4j | LNR | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.444 | |
| 5jad | FB2 | Platelet-activating factor acetylhydrolase | 3.1.1.47 | 0.444 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.444 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.443 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.443 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.443 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2fiw | ACO | GCN5-related N-acetyltransferase:Aminotransferase, class-II | / | 0.443 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.443 | |
| 3up3 | XCA | aceDAF-12 | / | 0.443 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.443 | |
| 4iv0 | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.443 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.443 | |
| 1dc6 | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.442 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.442 | |
| 1j4j | ACO | Acetyltransferase | 2.3.1 | 0.442 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.442 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.442 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3frk | TQP | QdtB | / | 0.442 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.442 | |
| 3reo | SAH | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.442 | |
| 3uj7 | SAM | Phosphoethanolamine N-methyltransferase | / | 0.442 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.442 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.442 | |
| 4juc | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.442 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.442 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 4zea | IMI | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 1n06 | ADP | Riboflavin kinase | 2.7.1.26 | 0.441 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 2pa7 | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.441 | |
| 2xeg | CI9 | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.441 | |
| 3nw2 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.441 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.441 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.441 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.441 | |
| 1af7 | SAH | Chemotaxis protein methyltransferase | 2.1.1.80 | 0.440 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.440 | |
| 1ez0 | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.440 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.440 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 3elu | SAM | Methyltransferase | / | 0.440 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3k7t | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.440 | |
| 3nju | ANN | Acidic phospholipase A2 3 | 3.1.1.4 | 0.440 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.440 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.440 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 4y3q | F02 | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.440 | |
| 5jjr | SAH | Genome polyprotein | / | 0.440 |