sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1jx0 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1jx0 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 1.000 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.520 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.500 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.490 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.485 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.485 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.481 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.481 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.480 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.480 | |
| 5doz | NDP | JamJ | / | 0.476 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.475 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.473 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.472 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.472 | |
| 1mb9 | ATP | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.471 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.471 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.470 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.470 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.470 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.470 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.469 | |
| 1osv | CHC | Bile acid receptor | / | 0.469 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.469 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.469 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.468 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.468 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.468 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.467 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.467 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.467 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.467 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.466 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.466 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.466 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.466 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.466 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2wpw | ACO | Orf14 | / | 0.465 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 3nsz | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.465 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.464 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.464 | |
| 4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 0.464 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.463 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.463 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 3tzl | ADP | Tryptophan--tRNA ligase | / | 0.463 | |
| 3zvv | XAZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 4at8 | ATP | Interleukin enhancer-binding factor 2 | / | 0.463 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.463 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.463 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1fm8 | DDC | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.462 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.462 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.462 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.461 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.461 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.461 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.461 | |
| 4bdf | H3R | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.461 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.460 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.460 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.460 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.459 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3lin | E13 | Protease | / | 0.459 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.459 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.458 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.458 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.458 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.458 | |
| 3qcl | NXV | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.458 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.458 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.458 | |
| 4l8u | 9AZ | Serum albumin | / | 0.458 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.457 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.457 | |
| 4e2b | FMN | Dehydrogenase | / | 0.457 | |
| 5ag5 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2bxi | AZQ | Serum albumin | / | 0.456 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.456 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.456 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 4jap | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.456 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.455 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.455 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.455 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.455 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.455 | |
| 2rki | TT1 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.455 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.455 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.455 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.455 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.455 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.455 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.455 | |
| 5auu | LU2 | Death-associated protein kinase 1 | 2.7.11.1 | 0.455 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.454 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.454 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.454 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.454 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.453 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.453 | |
| 3g6w | GTP | Uracil phosphoribosyltransferase | 2.4.2.9 | 0.453 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.453 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 4gah | 0ET | Acyl-coenzyme A thioesterase THEM4 | 3.1.2.2 | 0.453 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.453 | |
| 4l9q | 9TP | Serum albumin | / | 0.453 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.453 | |
| 5kgj | ACO | Predicted acetyltransferase | / | 0.453 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.453 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.452 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.452 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.452 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2pv7 | NAD | T-protein | 1.3.1.12 | 0.452 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.452 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.452 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.452 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.451 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.451 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.451 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.451 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.451 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.451 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.451 | |
| 4b1v | ATP | Actin, alpha skeletal muscle | / | 0.451 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.451 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.451 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.450 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.450 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.450 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.450 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 2p15 | EZT | Estrogen receptor | / | 0.450 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.450 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 3i0s | RT7 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.450 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.450 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.450 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.450 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.450 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.449 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.449 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.449 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.449 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.449 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.449 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.449 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.449 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3zux | TCH | Transporter | / | 0.449 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.449 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.449 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.449 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.449 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.449 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.449 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1g67 | TZP | Thiamine-phosphate synthase | / | 0.448 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 1um0 | FMN | Chorismate synthase | / | 0.448 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.448 | |
| 2dbz | NAP | Glyoxylate reductase | 1.1.1.26 | 0.448 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.448 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.448 | |
| 3dol | GWI | Pol protein | / | 0.448 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3upf | 0BU | Polyprotein | / | 0.448 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.448 | |
| 4akn | S5B | Bromodomain-containing protein 2 | / | 0.448 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.448 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.448 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.448 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.448 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.448 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.447 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.447 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.447 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.447 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3k3b | ADP | Kinesin-like protein KIF11 | / | 0.447 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.447 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.447 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.447 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.447 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.447 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.447 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.446 | |
| 1gjr | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.446 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.446 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.446 | |
| 3ge1 | ADP | Glycerol kinase | / | 0.446 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.446 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.446 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.446 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4i3z | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4nvk | 2NY | Peroxidase | / | 0.446 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.446 | |
| 5c4n | NAP | Precorrin-6A reductase | 1.3.1.54 | 0.446 | |
| 5j23 | A2R | Putative 2-hydroxyacid dehydrogenase | / | 0.446 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.446 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.445 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2r9k | SGI | Beta-galactoside-specific lectin 1 | / | 0.445 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.445 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.445 | |
| 3hky | IX6 | Genome polyprotein | 2.7.7.48 | 0.445 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.445 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4ftj | H8K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.445 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1qzf | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.444 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.444 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.444 | |
| 2hj3 | FAD | FAD-linked sulfhydryl oxidase ERV1 | / | 0.444 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.444 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 3dvl | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.444 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.444 | |
| 3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.444 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.444 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.444 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.444 | |
| 4nr4 | 2LK | CREB-binding protein | / | 0.444 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.444 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1ayl | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.443 | |
| 1ckp | PVB | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.443 | |
| 1fbm | RTL | Cartilage oligomeric matrix protein | / | 0.443 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.443 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.443 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.443 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.443 | |
| 2bxm | IMN | Serum albumin | / | 0.443 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.443 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.443 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.443 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.443 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.443 | |
| 4bdd | Z0O | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.443 | |
| 4fdp | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.443 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.443 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.443 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.443 | |
| 5a3c | NAD | SIR2 family protein | / | 0.443 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 5dp2 | NAP | CurF | / | 0.443 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.442 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.442 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.442 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.442 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.442 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.442 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3fro | NHF | GlgA glycogen synthase | / | 0.442 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.442 | |
| 3v3v | MYU | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.442 | |
| 4c4i | X20 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.442 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.442 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.442 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.442 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.442 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.442 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.442 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1eio | GCH | Gastrotropin | / | 0.441 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.441 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.441 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.441 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.441 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.441 | |
| 3eem | 53V | Uncharacterized protein | / | 0.441 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.441 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.441 | |
| 3nhw | ZXZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.441 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4egn | TWO | Cytochrome P450 | / | 0.441 | |
| 4ft3 | H1K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4ftc | H6K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4h50 | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.441 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.441 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.441 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.441 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.441 | |
| 4ylh | YE1 | (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase | / | 0.441 | |
| 5l7d | CLR | Smoothened homolog | / | 0.441 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.440 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.440 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.440 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.440 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.440 | |
| 2y3r | TRK | TamL | / | 0.440 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.440 | |
| 3eej | 53R | Uncharacterized protein | / | 0.440 | |
| 3gep | 24H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.440 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3iw7 | IPK | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3liv | E16 | Protease | / | 0.440 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.440 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4c2x | NHW | Glycylpeptide N-tetradecanoyltransferase 2 | / | 0.440 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.440 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.440 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.440 | |
| 5a3b | APR | SIR2 family protein | / | 0.440 |