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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jcq739Protein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1jcq739Protein farnesyltransferase subunit beta2.5.1.581.000
1s63778Protein farnesyltransferase subunit beta2.5.1.580.755
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.746
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.743
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.718
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.677
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.623
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.617
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.615
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.594
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.594
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.591
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.577
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.577
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.565
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.554
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.554
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.514
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.507
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.486
3sfy3FYUncharacterized protein/0.472
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.470
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.458
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.451
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.446
3q7fED2Uncharacterized protein/0.446
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.440