sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1j9g | FMN | Flavodoxin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1j9g | FMN | Flavodoxin | / | 1.000 | |
| 1fx1 | FMN | Flavodoxin | / | 0.628 | |
| 1wsb | FMN | Flavodoxin | / | 0.604 | |
| 1akw | FMN | Flavodoxin | / | 0.597 | |
| 1azl | FMN | Flavodoxin | / | 0.597 | |
| 4fx2 | FMN | Flavodoxin | / | 0.596 | |
| 2fx2 | FMN | Flavodoxin | / | 0.594 | |
| 3f6r | FMN | Flavodoxin | / | 0.582 | |
| 5tgz | FMN | Cannabinoid receptor 1 | / | 0.571 | |
| 1j8q | FMN | Flavodoxin | / | 0.569 | |
| 1akr | FMN | Flavodoxin | / | 0.566 | |
| 3kap | FMN | Flavodoxin | / | 0.559 | |
| 4y7c | FMN | NADPH--cytochrome P450 reductase | / | 0.559 | |
| 3kaq | FMN | Flavodoxin | / | 0.552 | |
| 1c7f | FMN | Flavodoxin | / | 0.548 | |
| 1bu5 | RBF | Flavodoxin | / | 0.545 | |
| 1xyv | FMN | Flavodoxin | / | 0.543 | |
| 4oxx | FMN | Cindoxin | / | 0.543 | |
| 5fx2 | FMN | Flavodoxin | / | 0.540 | |
| 1aku | FMN | Flavodoxin | / | 0.539 | |
| 1xyy | FMN | Flavodoxin | / | 0.532 | |
| 5xra | FMN | Cannabinoid receptor 1 | / | 0.528 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.514 | |
| 1ofv | FMN | Flavodoxin | / | 0.508 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.502 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.502 | |
| 1czn | FMN | Flavodoxin | / | 0.494 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.492 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.491 | |
| 2mok | FMN | Flavodoxin 1 | / | 0.491 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.491 | |
| 1ahn | FMN | Flavodoxin 1 | / | 0.490 | |
| 2fcr | FMN | Flavodoxin | / | 0.488 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.488 | |
| 3ndj | JHZ | Methyltransferase | / | 0.487 | |
| 2ejz | SAH | Diphthine synthase | / | 0.485 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.485 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.484 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.483 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.483 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.481 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.480 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.479 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.479 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.479 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.478 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.478 | |
| 2v5u | FMN | Flavodoxin | / | 0.476 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.476 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.476 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.476 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.476 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.475 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.474 | |
| 4e2d | FMN | Dehydrogenase | / | 0.474 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 4e32 | DWN | Methyltransferase | / | 0.473 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.473 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.472 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.472 | |
| 2r5n | TPP | Transketolase 1 | / | 0.470 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.470 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.469 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.468 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.467 | |
| 1ykg | FMN | Sulfite reductase [NADPH] flavoprotein alpha-component | / | 0.467 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.467 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.467 | |
| 3esy | FMN | Flavodoxin | / | 0.466 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.466 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.465 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.465 | |
| 2qe2 | 452 | Polyprotein | / | 0.465 | |
| 4uaj | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.465 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.464 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.464 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.464 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.464 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.464 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.463 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.463 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.463 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.463 | |
| 3gr8 | FMN | NADPH dehydrogenase | / | 0.463 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.463 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.463 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.462 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.462 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.462 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.462 | |
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.462 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.462 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.462 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.461 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.461 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.461 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.461 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.461 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.461 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.461 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.461 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.460 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.460 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.460 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.459 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.459 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.459 | |
| 5xr8 | FMN | Cannabinoid receptor 1 | / | 0.459 | |
| 2gms | P0P | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.458 | |
| 3gu3 | SAH | Methyltransferase | / | 0.458 | |
| 4jjk | FOL | Formate--tetrahydrofolate ligase | / | 0.458 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.457 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.457 | |
| 2avx | HTF | Regulatory protein SdiA | / | 0.457 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.457 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.457 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.457 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.457 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.456 | |
| 2dsh | SAH | Diphthine synthase | / | 0.456 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.456 | |
| 2r8o | T5X | Transketolase 1 | / | 0.456 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.456 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.456 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.455 | |
| 1dor | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.455 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.455 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.455 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.455 | |
| 2c9b | PUG | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.455 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.455 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.455 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.454 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.454 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.454 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.454 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.454 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.454 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.454 | |
| 4to0 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.454 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.454 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.453 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 1j9z | FMN | NADPH--cytochrome P450 reductase | / | 0.453 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.453 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.453 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.453 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.453 | |
| 3irh | DTP | HD domain protein | / | 0.453 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.453 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.453 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.453 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.453 | |
| 4bmp | FMN | Protein NrdI | / | 0.453 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.453 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.453 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.453 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.453 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.452 | |
| 2r8p | T6F | Transketolase 1 | / | 0.452 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.452 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.452 | |
| 4fri | DWA | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 1ri4 | SAM | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.451 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.451 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.451 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.451 | |
| 2zts | ADP | Uncharacterized protein | / | 0.451 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.451 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.451 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.451 | |
| 5cho | FAD | Flavin reductase | / | 0.451 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.451 | |
| 2zrx | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.450 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.450 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.450 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2v8p | CDP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.449 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3anl | SYC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.449 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.449 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 4l8u | 9AZ | Serum albumin | / | 0.449 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.448 | |
| 3f6s | FMN | Flavodoxin | / | 0.448 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.448 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.448 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.447 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.447 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.447 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.447 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.447 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3bnk | FMN | Flavoredoxin | / | 0.447 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.447 | |
| 4e2z | JHZ | Methyltransferase | / | 0.447 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.447 | |
| 1fue | FMN | Flavodoxin | / | 0.446 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.446 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.446 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.446 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 2gl0 | ADN | Uncharacterized protein | / | 0.446 | |
| 2gmu | PDG | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.446 | |
| 2jgs | BTN | Avidin | / | 0.446 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 3p8h | P8H | Lethal(3)malignant brain tumor-like protein 1 | / | 0.446 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.446 | |
| 3v2u | ATP | Protein GAL3 | / | 0.446 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.446 | |
| 4d96 | 5PA | D-cysteine desulfhydrase | / | 0.446 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.445 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.445 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.445 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.445 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.445 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4l8v | NAP | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.445 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.445 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.444 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.444 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.444 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.444 | |
| 3dz2 | A8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.444 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.444 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.444 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.444 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 1fdr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.443 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.443 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 2o8b | ADP | DNA mismatch repair protein Msh2 | / | 0.443 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 2w0w | LZS | Bifunctional protein GlmU | / | 0.443 | |
| 2wq7 | FAD | RE11660p | / | 0.443 | |
| 2xlu | NA7 | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2y01 | Y00 | Beta-1 adrenergic receptor | / | 0.443 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.443 | |
| 3kt3 | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.443 | |
| 3w2f | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.443 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.442 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.442 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.442 | |
| 3ipk | PMS | Surface protein adhesin | / | 0.442 | |
| 3klb | FMN | Uncharacterized protein | / | 0.442 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.442 | |
| 4e2y | JHZ | Methyltransferase | / | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.442 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.441 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ngs | TPP | Transketolase 1 | 2.2.1.1 | 0.441 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.441 | |
| 1tkb | N1T | Transketolase 1 | 2.2.1.1 | 0.441 | |
| 1v45 | 3DG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.441 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.441 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2uzh | CDP | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.441 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.441 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.441 | |
| 3ho9 | N3A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.441 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.441 | |
| 3m4p | 4AD | Asparaginyl-tRNA synthetase, putative | / | 0.441 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.441 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.441 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.440 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.440 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.440 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2cv1 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.440 | |
| 2v34 | CTN | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 2wp9 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.440 | |
| 2wp9 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.440 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.440 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.440 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.440 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4j0p | 1H8 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.440 |