scPDB - Distribution of Cavity Similarity values of 1j3k entry / Site 2

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	1.000
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.630
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.623
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.622
3qly	55V	Uncharacterized protein	/	0.620
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.618
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.604
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.602
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.597
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.590
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.589
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.584
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.579
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.578
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.578
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.571
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.571
3qlx	QLR	Uncharacterized protein	/	0.570
3cse	N22	Uncharacterized protein	/	0.566
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.564
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.563
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.563
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.560
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.557
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.556
3eej	53R	Uncharacterized protein	/	0.556
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.556
3qlz	QLZ	Uncharacterized protein	/	0.555
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.552
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.549
3eek	53S	Uncharacterized protein	/	0.547
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.546
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.545
3eem	53V	Uncharacterized protein	/	0.539
4h98	14Q	Uncharacterized protein	/	0.535
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.531
3eel	53T	Uncharacterized protein	/	0.531
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.531
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.531
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.525
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.524
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.523
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.521
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.515
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.515
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.510
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.509
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.508
3dga	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.507
2zza	FOL	Dihydrofolate reductase	/	0.506
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.504
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.503
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.500
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.497
2w3v	TOP	Dihydrofolate reductase	/	0.495
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.495
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.495
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.495
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.494
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.493
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.492
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.487
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.485
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.484
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.484
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.484
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.483
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.482
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.481
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.481
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.479
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.479
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.479
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.478
3ia4	MTX	Dihydrofolate reductase	/	0.477
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.476
3tq9	MTX	Dihydrofolate reductase	/	0.471
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.470
4nky	3QZ	Steroid 17-alpha-hydroxylase/17,20 lyase	/	0.470
3inv	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.469
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.468
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.465
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.463
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.463
3jw5	TOP	Dihydrofolate reductase	/	0.463
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.463
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.463
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.462
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.461
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.461
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.460
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.459
4ia7	BIV	Vitamin D3 receptor A	/	0.459
4p66	MTX	Dihydrofolate reductase	/	0.458
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.457
3jwc	EKB	Dihydrofolate reductase	/	0.457
4j6c	STR	Cytochrome P450 monooxygenase	/	0.457
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.456
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.456
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.455
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.454
3dat	MTX	Dihydrofolate reductase	/	0.454
3sa1	6DR	Dihydrofolate reductase	/	0.454
3jwm	5WB	Dihydrofolate reductase	/	0.451
3ruk	AER	Steroid 17-alpha-hydroxylase/17,20 lyase	/	0.451
2hw2	RFP	Rifampin ADP-ribosyl transferase	/	0.450
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.448
3tqb	FOL	Dihydrofolate reductase	/	0.448
4fgh	0U6	Dihydrofolate reductase	1.5.1.3	0.447
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.447
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.446
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.446
3sgy	06W	Dihydrofolate reductase	1.5.1.3	0.446
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.446
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.445
3hcr	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.445
4ia2	BIV	Vitamin D3 receptor A	/	0.445
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.443
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.443
1m79	MQ1	Dihydrofolate reductase	1.5.1.3	0.442
3bfa	9OD	Odorant binding protein ASP1	/	0.441
4ib4	ERM	5-hydroxytryptamine receptor 2B	/	0.441
2tsc	CB3	Thymidylate synthase	/	0.440