sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1itz	TPP	Transketolase, chloroplastic	2.2.1.1

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1itz	TPP	Transketolase, chloroplastic	2.2.1.1	1.000
2r5n	TPP	Transketolase 1	/	0.588
3upt	TPP	Transketolase	/	0.587
1tka	N3T	Transketolase 1	2.2.1.1	0.579
1trk	TPP	Transketolase 1	2.2.1.1	0.573
1ay0	TPP	Transketolase 1	2.2.1.1	0.568
1tkb	N1T	Transketolase 1	2.2.1.1	0.558
1tkc	M6T	Transketolase 1	2.2.1.1	0.548
1ngs	TPP	Transketolase 1	2.2.1.1	0.543
2o1x	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.480
2o1s	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.476
1umc	TDP	2-oxoisovalerate dehydrogenase subunit alpha	1.2.4.4	0.447
1umc	TDP	2-oxoisovalerate dehydrogenase subunit beta	1.2.4.4	0.447