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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ibrGNPGTP-binding nuclear protein Ran

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ibrGNPGTP-binding nuclear protein Ran/1.000
5dhaGNPGTP-binding nuclear protein Ran/0.609
5jljGNPGTP-binding nuclear protein Ran/0.576
2zetGTPRas-related protein Rab-27B/0.559
3rabGNPRas-related protein Rab-3A/0.556
1xtsGTPGTP-binding protein Rheb/0.543
1xtrGNPGTP-binding protein Rheb/0.517
4nyiGNPGTPase HRas/0.516
1yzqGNPRas-related protein Rab-6A/0.514
5b2zGNPGTPase HRas/0.512
3oiuGNPGTPase HRas/0.511
4nyjGNPGTPase HRas/0.511
3lbnGNPGTPase HRas/0.508
4dltGNPGTPase HRas/0.507
3rs5GNPGTPase HRas/0.506
3tsoGNPRas-related protein Rab-25/0.505
1g17GNPRas-related protein SEC4/0.500
3bc1GNPRas-related protein Rab-27A/0.498
3e5hGNPRas-related protein Rab-28/0.498
3ea5GDPGTP-binding nuclear protein Ran/0.498
3w3zGTPGTP-binding nuclear protein Ran/0.498
3v4fGNPGTPase HRas/0.494
1zc3GNPRas-related protein Ral-A/0.491
4cymGCPRas-related protein Rab-32/0.491
3oivGNPGTPase HRas/0.490
3qbtGNPRas-related protein Rab-8A/0.487
4o25GTPGTP-binding protein Rheb/0.486
3kz1GSPTransforming protein RhoA/0.485
1k5dGNPGTP-binding nuclear protein Ran/0.484
4mitGTPRho-related protein racC/0.483
1zbdGTPRas-related protein Rab-3A/0.482
1kmqGNPTransforming protein RhoA/0.481
3rs7GNPGTPase HRas/0.480
3oesGNPGTPase RhebL1/0.479
1zc4GNPRas-related protein Ral-A/0.476
3bbpGTPRas-related protein Rab-6A/0.476
4qxaGTPRas-related protein Rab-9A/0.476
1s1cGNPTransforming protein RhoA/0.472
2clsGTPRho-related GTP-binding protein Rho6/0.472
3i3sGNPGTPase HRas/0.470
3kucGDPRas-related protein Rap-1A/0.468
5hpyGDPTransforming protein RhoA/0.467
1cxzGSPTransforming protein RhoA/0.464
4lhwGNPRas-related protein Rab-8A/0.464
4rkfGNPRas-related protein Rab-3/0.464
4dsoGSPGTPase KRas/0.463
3eg5GNPCell division control protein 42 homolog/0.462
3a6pGTPGTP-binding nuclear protein Ran/0.460
2bkuGTPGTP-binding nuclear protein Ran/0.459
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.458
1oixGDPRas-related protein Rab-11A/0.457
3ddcGNPGTPase HRas/0.456
1ow3GDPTransforming protein RhoA/0.455
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.455
4dlwGNPGTPase HRas/0.455
4dxaGSPRas-related protein Rap-1b/0.452
3a58GNPGTP-binding protein RHO1/0.451
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.450
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.449
2ffqGSPRas-related protein Rab-6B/0.448
1t91GTPRas-related protein Rab-7a/0.446
1yhnGTPRas-related protein Rab-7a/0.446
4uj3GNPRas-related protein Rab-11A/0.446
1vg8GNPRas-related protein Rab-7a/0.445
4xoiGTPTransforming protein RhoA/0.442
4kvgGTPRas-related protein Rap-1A/0.441
5difGNPGTP-binding nuclear protein Ran/0.441
1u0hGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.440