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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hckATPCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1hckATPCyclin-dependent kinase 22.7.11.221.000
1b38ATPCyclin-dependent kinase 22.7.11.220.566
4fki09KCyclin-dependent kinase 22.7.11.220.561
3r1yX76Cyclin-dependent kinase 22.7.11.220.560
3r7yZ04Cyclin-dependent kinase 22.7.11.220.554
3lfqA28Cyclin-dependent kinase 22.7.11.220.550
2exmZIPCyclin-dependent kinase 22.7.11.220.548
3qwjX6ACyclin-dependent kinase 22.7.11.220.545
3lfnA27Cyclin-dependent kinase 22.7.11.220.544
3r83Z14Cyclin-dependent kinase 22.7.11.220.543
2a4lRRCCyclin-dependent kinase 22.7.11.220.533
3r8lZ30Cyclin-dependent kinase 22.7.11.220.530
1oitHDTCyclin-dependent kinase 22.7.11.220.529
1ke5LS1Cyclin-dependent kinase 22.7.11.220.522
2xmyCDKCyclin-dependent kinase 22.7.11.220.521
1pxlCK4Cyclin-dependent kinase 22.7.11.220.517
3rpo24ZCyclin-dependent kinase 22.7.11.220.514
2btsU32Cyclin-dependent kinase 22.7.11.220.513
1b39ATPCyclin-dependent kinase 22.7.11.220.510
3qzgX67Cyclin-dependent kinase 22.7.11.220.509
1y91CT9Cyclin-dependent kinase 22.7.11.220.508
2c5yMTWCyclin-dependent kinase 22.7.11.220.506
2r3jSCJCyclin-dependent kinase 22.7.11.220.504
3iggEFQCyclin-dependent kinase 22.7.11.220.504
1pxoCK7Cyclin-dependent kinase 22.7.11.220.503
2a0cCK9Cyclin-dependent kinase 22.7.11.220.498
1w8cN69Cyclin-dependent kinase 22.7.11.220.497
2c6o4SPCyclin-dependent kinase 22.7.11.220.497
3r8vZ62Cyclin-dependent kinase 22.7.11.220.496
4fkpLS5Cyclin-dependent kinase 22.7.11.220.495
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.492
3rk708ZCyclin-dependent kinase 22.7.11.220.492
1y8yCT7Cyclin-dependent kinase 22.7.11.220.491
1ykr628Cyclin-dependent kinase 22.7.11.220.491
2b52D42Cyclin-dependent kinase 22.7.11.220.491
2uzoC62Cyclin-dependent kinase 22.7.11.220.491
1oirHDYCyclin-dependent kinase 22.7.11.220.489
1w0xOLOCyclin-dependent kinase 22.7.11.220.487
3rk909ZCyclin-dependent kinase 22.7.11.220.485
3qtxX43Cyclin-dependent kinase 22.7.11.220.481
4fkq42KCyclin-dependent kinase 22.7.11.220.481
4ek816KCyclin-dependent kinase 22.7.11.220.480
4fkj11KCyclin-dependent kinase 22.7.11.220.479
3rak03ZCyclin-dependent kinase 22.7.11.220.475
4fkv61KCyclin-dependent kinase 22.7.11.220.475
3r71X86Cyclin-dependent kinase 22.7.11.220.474
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.473
4fklCK2Cyclin-dependent kinase 22.7.11.220.472
2c6kDT2Cyclin-dependent kinase 22.7.11.220.471
1gii1PUCyclin-dependent kinase 22.7.11.220.470
1pxmCK5Cyclin-dependent kinase 22.7.11.220.470
2ds11CDCyclin-dependent kinase 22.7.11.220.470
3s1h56ZCyclin-dependent kinase 22.7.11.220.470
2b53D23Cyclin-dependent kinase 22.7.11.220.469
3r9dX6BCyclin-dependent kinase 22.7.11.220.468
3qxoX65Cyclin-dependent kinase 22.7.11.220.467
3qu0X40Cyclin-dependent kinase 22.7.11.220.466
2vtrLZBCyclin-dependent kinase 22.7.11.220.464
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.462
2vv9IM9Cyclin-dependent kinase 22.7.11.220.462
2uznC96Cyclin-dependent kinase 22.7.11.220.461
3rm719ZCyclin-dependent kinase 22.7.11.220.460
4fkg4CKCyclin-dependent kinase 22.7.11.220.460
2duv371Cyclin-dependent kinase 22.7.11.220.459
3nieANPMitogen-activated protein kinase/0.458
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.456
3qqlX03Cyclin-dependent kinase 22.7.11.220.456
3r7vZ02Cyclin-dependent kinase 22.7.11.220.455
1g5sI17Cyclin-dependent kinase 22.7.11.220.454
3ezvEZVCyclin-dependent kinase 22.7.11.220.453
4ek610KCyclin-dependent kinase 22.7.11.220.453
2vthLZ2Cyclin-dependent kinase 22.7.11.220.452
4fkt48KCyclin-dependent kinase 22.7.11.220.451
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.451
2vtqLZACyclin-dependent kinase 22.7.11.220.450
1e1xNW1Cyclin-dependent kinase 22.7.11.220.449
3qtuX44Cyclin-dependent kinase 22.7.11.220.448
3raiX85Cyclin-dependent kinase 22.7.11.220.448
3s2pPMUCyclin-dependent kinase 22.7.11.220.448
2vu3LZECyclin-dependent kinase 22.7.11.220.447
4kd11QKCyclin-dependent kinase 22.7.11.220.447
3r7uX96Cyclin-dependent kinase 22.7.11.220.446
3rahO1ZCyclin-dependent kinase 22.7.11.220.446
1h1r6CPCyclin-dependent kinase 22.7.11.220.445
2r3kSCQCyclin-dependent kinase 22.7.11.220.445
2vtsLZCCyclin-dependent kinase 22.7.11.220.444
4dgnLU2Casein kinase II subunit alpha2.7.11.10.444
3le62BZCyclin-dependent kinase 22.7.11.220.442
3plsANPMacrophage-stimulating protein receptor2.7.10.10.442
3rni21ZCyclin-dependent kinase 22.7.11.220.442
4jboWPHAurora kinase A2.7.11.10.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
3qqgX06Cyclin-dependent kinase 22.7.11.220.440
3rpv26ZCyclin-dependent kinase 22.7.11.220.440
4fks46KCyclin-dependent kinase 22.7.11.220.440